Bone Disease in Patients With Primary Sclerosing Cholangitis

Angulo, Paul; Grandison, Garfield A.; Fong, Derek G.; Keach, Jill C.; Lindor, Keith D.; Bjõrnsson, Einar; Koch, Alvaro

doi:10.1053/j.gastro.2010.10.014

Cited by 107 publications

(71 citation statements)

References 46 publications

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“…Leptin also causes to receptor activator of nuclear factor kappa-B ligand (RANKL) production inhibition and diminishing bone resorption. Patients with cholestatic liver disease also show decreased leptin levels (23)(24)(25). The prevalence of bone fractures was 20.8% in primary biliary cirrhosis patients (26).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of mandibular inferior cortex changes in patients candidate for liver and kidney transplantation using panoramic view

Ghapanchi¹,

Haghnegahdar²,

Faghih³

et al. 2017

J Nephropathol

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Section: Discussionmentioning

confidence: 99%

Evaluation of mandibular inferior cortex changes in patients candidate for liver and kidney transplantation using panoramic view

Ghapanchi¹,

Haghnegahdar²,

Faghih³

et al. 2017

J Nephropathol

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“…The association between AiLD and aPL-related thrombotic complications has been documented by several J Gastrointestin Liver Dis, March 2015 Vol. 24 No 1: [25][26][27][28][29][30][31][32][33][34] studies [18,27,34,35]. However, most of these studies are case-reports.…”

Section: Discussionmentioning

confidence: 99%

“…24 No 1: [25][26][27][28][29][30][31][32][33][34] mechanism [8,9]. Although classically considered as distinct entities, these autoimmune liver diseases (AiLD) may share biochemical and immunological features [9,10], such as the positivity of specific autoantibodies [11,12], that plays a central role in the diagnosis and classification of AiLD [13].…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Liver Diseases and Antiphospholipid Antibodies Positivity: a Meta-analysis of Literature Studies

Ambrosino

Lupoli

Spadarella

et al. 2015

JGLD

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Background & Aims: Several studies reported an association between autoimmune liver diseases (AiLD) and antiphospholipid antibodies (aPL) positivity. We performed a meta-analysis of studies evaluating the association of primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC) with aPL positivity and with aPL-related thrombotic events.Methods: Studies evaluating the association of AiLD with aPL (anticardiolipin [aCL], anti-β2 glycoprotein-I [anti-β2GPI], lupus anticoagulant [LA] antibodies) and with aPL-related thrombotic complications were systematically searched in the PubMed, Web of Science, Scopus and EMBASE databases.Results: A total of 10 studies (750 patients with AiLD and 1,244 healthy controls) were included in the analysis on the prevalence of aPL and showed that AiLD are significantly associated with the presence of aCL and anti-β2GPI. The association with aCL positivity was consistently confirmed in PBC (OR: 13.93, 95%CI: 4.69-41.38), AIH (OR: 23.50, 95%CI: 4.28-129.13), and PSC (OR: 18.21, 95%CI: 7.05-47.08). Similarly, anti-β2GPI were found more frequently in PBC (OR: 25.10, 95%CI: 4.77-132.11), AIH (OR: 48.57, 95%CI: 11.07-213.09), and PSC (OR: 36.30, 95%CI: 6.55-201.31). These findings are confirmed when separately analyzing IgM, IgG, and IgA directed against phospholipids. Two of the 10 included articles and 1 further study (67 cases and 75 controls) showed a trend - not achieving statistical significance - towards a higher prevalence of thrombotic complications in AIH patients with aPL as compared to those with only AIH (OR: 1.67, 95%CI: 0.46-6.05).Conclusion: PBC, AIH, and PSC are significantly associated with aPL positivity. The association with aPL-related thrombotic complications should be further studied.

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“…As with other chronic liver diseases, there is an increased prevalence of osteoporosis in PSC, of the order of 15-30% [29]. Its presence does not appear to depend upon the severity of the underlying PSC [30].…”

Section: Osteoporosismentioning

confidence: 99%

Primary Sclerosing Cholangitis

Williamson

Chapman

2014

Dig Dis

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Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease caused by diffuse inflammation and fibrosis that can involve the entire biliary tree. It is a progressive disorder which can ultimately lead to biliary cirrhosis, portal hypertension and hepatic failure. PSC is a complex genetic disorder with male predominance. Environmental predisposing factors include non-smoking. It is closely associated with inflammatory bowel disease (IBD), particularly ulcerative colitis, which occurs in about two thirds of PSC cases. Recent studies have suggested that PSC-IBD is a separate disease entity from IBD alone with distinctive genetic and phenotypic characteristics. Most PSC patients are asymptomatic at presentation; clinical symptoms include fatigue, jaundice, weight loss, right upper quadrant pain and pruritis. Serum biochemical tests indicate cholestasis, and diagnosis is usually established by cholangiography. In symptomatic patients, median survival from presentation to death or liver transplantation is about 12 years. It is a premalignant condition, and the majority of deaths are from malignancy, particularly cholangiocarcinoma or colonic cancer. PSC has no curative treatment. Medical treatment with ursodeoxycholic acid may slow progression of the disease and reduce colonic dysplasia, though trials lack statistical significance. Liver transplantation is the only option in young patients with PSC and advanced liver disease.

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Bone Disease in Patients With Primary Sclerosing Cholangitis

Cited by 107 publications

References 46 publications

Evaluation of mandibular inferior cortex changes in patients candidate for liver and kidney transplantation using panoramic view

Evaluation of mandibular inferior cortex changes in patients candidate for liver and kidney transplantation using panoramic view

Autoimmune Liver Diseases and Antiphospholipid Antibodies Positivity: a Meta-analysis of Literature Studies

Primary Sclerosing Cholangitis

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