Bone diseases in rabbits with hyperparathyroidism: computed tomography, magnetic resonance imaging and histopathology

Renju, Bai; Cong, Degang; Shen, Baogen; Han, Min; Wu, Zhenhua

doi:10.1097/00029330-200608010-00004

Cited by 7 publications

(7 citation statements)

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“…Several other authors indicate that osteoporosis may result in decreased oral bone density and alveolar bone loss (Cai , Bai et al . ). Ashcraft et al .…”

Section: Dental Diseasementioning

confidence: 97%

“…However, in advanced NSHP (dietary calcium to phosphorus ratio 1:7), Bai et al . () described higher total calcium concentrations with high basal PTH concentrations reaching 201·3 pg/mL. PTH concentrations higher than 430 pg/mL could be explained by concurrent renal failure (Bas et al .…”

Section: Dental Diseasementioning

confidence: 99%

“…Several other authors indicate that osteoporosis may result in decreased oral bone density and alveolar bone loss (Cai 1992, Bai et al 2006. Ashcraft et al (1992) described that osteoporosis affects the rate of tooth movement through the involvement of alveolar bone and consequent periodontal and dental problems influence the response even to the physiological orthodontic forces.…”

Section: Effects Of Dietary Phosphorus On Dental Diseasementioning

confidence: 99%

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Rabbit dental disease and calcium metabolism – the science behind divided opinions

Jekl

Redrobe

2013

J of Small Animal Practice

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Dental disease is considered as one of the, if not, the most common disorders seen in pet rabbits. This article provides a review of the scientific literature and an overview of the peculiarities of calcium homeostasis in the rabbit in an attempt to draw together current thinking on the cause of dental disease. A complete understanding of the aetiology and pathophysiology of rabbit dental disease is necessary for the veterinary practitioner to establish a proper therapeutic plan, prognosis and ultimately prevention of this common cause of morbidity and mortality in pet rabbits.

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“…Several other authors indicate that osteoporosis may result in decreased oral bone density and alveolar bone loss (Cai , Bai et al . ). Ashcraft et al .…”

Section: Dental Diseasementioning

confidence: 97%

Section: Dental Diseasementioning

confidence: 99%

Section: Effects Of Dietary Phosphorus On Dental Diseasementioning

confidence: 99%

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Rabbit dental disease and calcium metabolism – the science behind divided opinions

Jekl

Redrobe

2013

J of Small Animal Practice

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“…It has been shown that Met-PET/CT can provide an exact anatomical localization of parathyroid adenomas, which can give additional information for the operating surgeon, as only up to 60 % of DAs were often detected by only sestamibi scanning and ultrasonography [29]. Furthermore, single-photon emission computed tomography (SPECT) or magnetic resonance imaging (MRI) may be used as an additional diagnostic technique in cases of detection of atypical localization [35]. We suggest that Met-PET/ CT, MRI, or SPECT may serve as an additional detection technique in cases where sestamibi and ultrasonography results are discordant.…”

Section: Author Contributionsmentioning

confidence: 99%

One hundred double adenomas in primary hyperparathyroidism

et al. 2013

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One hundred double adenomas in primary hyperparathyroidism 295 1 3 SummaryBackground Double adenomas (DAs) occur in 2-15 % of primary hyperparathyroidism (pHPT) patients. To date, the existence of this distinct entity remains controversial. The aim of this study was to evaluate the clinical characteristics and anatomic distribution of DAs to identify anatomic patterns and implications for surgical management.Methods We reviewed prospective database records of 1,464 unselected, consecutive patients who were treated for pHPT in our institution between 1986 and 2012. We identified 100 DA patients (6.8 %) and compared their clinical characteristics with those of solitary adenomas (SAs; n = 1,226) and hyperplasia (including multiple endocrine neoplasia; n = 101).Results A total of 74 % of our patient collective was female. DAs were predominantly located on the right side (30 %) or crossed (23 %) and demonstrated an increased incidence of atypical position (38 %). Patients with DA showed significantly more neuropsychiatric disorders and pancreatitis compared with those in the other groups. Our results revealed higher parathyroid hormone levels in patients with DA compared with those with SA or hyperplasia. In 74 patients, the DA was primarily found, whereas 26 patients needed reoperation. Only nine DAs had developed metachronously. The overall cure rate of all patients with pHPT was 96.4 % (carcinomas excluded).Conclusions DAs are a distinct entity and show no specific characteristic features that could facilitate easy detection. The chance of a metachronous appearance is statistically low, but has significant clinical impact as a major cause for late recurrence of hyperparathyroidism and need for reoperation.Keywords Double adenoma · Primary hyperparathyroidism · Hyperplasia · Hypercalcemia Abbreviations DA double adenoma IOPTH intraoperative parathyroid hormone assay MEN multiple endocrine neoplasia PTH parathyroid hormone pHPT primary hyperparathyroidism SA single adenomaThe first two authors contributed equally to this work.

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“…A number of investigations have shown that the hormonal regulation of calcium metabolism exhibits a certain degree of seasonal variation. Both, serum levels of 25-hydroxyvitamin D3 (25OHD3) [17,18] and urinary calcium excretion [19] are elevated in late summer and decreased in winter, whereas PTH levels tend to increase during winter [20][21][22]. Less attention, however, has been paid to the annual variations in biochemical parameters of bone turnover.…”

Section: Introductionmentioning

confidence: 99%

Calcium Metabolism and Oxidative Stress in Bone Fractures: Role of Antioxidants

Sheweita

Khoshhal²

2007

CDM

198

152

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Calcium ion is an essential structural component of the skeleton. There is growing evidence for the importance of nutrition in the maintenance of bones and joints health. Nutritional imbalance combined with endocrine abnormalities may be involved in osteoporosis. For example, essential fatty acids and their metabolites were reported to have beneficial action in osteoporosis. The mechanism by which fatty acids prevent osteoporosis may involve inhibition of pro-inflammatory cytokines, which are known to have a major role in osteoporosis through induction of oxidative stress which had adverse effects on the skeleton. Other risk factors for osteoporosis, such as smoking, hypertension and diabetes mellitus are also associated with increased oxidative stress and free radicals levels. When bone fracture occurs, a remarkable yield of free radicals is generated by the damaged tissues. However, controlled production of free radicals by normally functioning osteoclasts could accelerate destruction of calcified tissues and assist bone remodeling. Enhanced osteoclastic activity observed in bone disorders may have been responsible for increased production of reactive oxygen species [ROS] in the form of superoxide, which is evident by increased levels of serum malondialdehyde [MDA] levels. One of the most damaging effects of ROS is lipid peroxidation, the end product of which is MDA which also served as a measure of osteoclastic activity. Inhibition of the antioxidant enzymes activities, such as superoxide dismutase and glutathione peroxidase, was found to increase superoxide production by the osteoclasts which represented by increased levels of MDA. Therefore, oxidative stress is an important mediator of bone loss since deficiency of antioxidant vitamins has been found to be more common in the elderly osteoporotic patients. It is concluded from this review that increased free radical production overwhelms the natural antioxidants defense mechanisms, subjecting individuals to hyperoxidant stress and thus leading to osteoporosis. In addition, administration of antioxidants might protect bones from osteoporosis and also might help in the acceleration of healing of fractured bones.

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Bone diseases in rabbits with hyperparathyroidism: computed tomography, magnetic resonance imaging and histopathology

Cited by 7 publications

References 8 publications

Rabbit dental disease and calcium metabolism – the science behind divided opinions

Rabbit dental disease and calcium metabolism – the science behind divided opinions

One hundred double adenomas in primary hyperparathyroidism

Calcium Metabolism and Oxidative Stress in Bone Fractures: Role of Antioxidants

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