Bone disorders in spontaneously hypertensive rat

Izawa, Yohei; Sagara, Kiyoshi; Kadota, Takashi; Makita, Tokutaro

doi:10.1007/bf02554916

Cited by 79 publications

(55 citation statements)

References 4 publications

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“…[55][56][57] As hypercalciuria is an important risk factor for the development of kidney stones, 58,59 both a high sodium diet and a high BP may be asso-…”

Section: Discussionmentioning

confidence: 99%

Urinary calcium excretion, sodium intake and blood pressure in a multi-ethnic population: results of the Wandsworth Heart and Stroke Study

et al. 2001

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Background: Hypertension is associated with increased urinary calcium excretion (UCa). A high sodium intake increases both UCa and blood pressure (BP). However, it is not clear whether these effects are modified by gender or ethnic origin. Objectives: To examine the relationships between BP, urinary sodium (UNa), gender and ethnic origin with both daily and fasting UCa in a population-based study. Design and Methods: Out of 1577 individuals taking part in a cross-sectional survey, 743 were considered for the present analysis (407 women, 336 men) as they were all untreated, had provided a complete 24-h urine collection, and had all measurements of anthropometry, BP, UNa and UCa. They were 277 whites, 227 of black African origin and 239 South Asians. Comparisons were also carried out in the 690 participants who also provided 3-h fasting urine collections. Results: After adjustment for confounders including age, and gender, 24-h UCa was significantly and independently associated with ethnic origin, BP and UNa. Mean 24-h UCa was 4.62 (s.e. 0.11) mmol/d in whites,

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“…[55][56][57] As hypercalciuria is an important risk factor for the development of kidney stones, 58,59 both a high sodium diet and a high BP may be asso-…”

Section: Discussionmentioning

confidence: 99%

Urinary calcium excretion, sodium intake and blood pressure in a multi-ethnic population: results of the Wandsworth Heart and Stroke Study

et al. 2001

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“…107 The SHR and Milan hypertensive rats are also more likely to develop bone demineralisation than their normotensive controls. 108,109 Thiazide diuretics which cause a reduction in calcium excretion when given to men and women with and without hypertension reduce the number of hip fractures. 110,111 Inasmuch as kidney stones are known to be associated with a raised urinary excretion of calcium it is probable that the salt-induced increase in urinary calcium excretion in SHR and essential hypertension contributes to their greater incidence of renal stones.…”

Section: Bone Density and Renal Stonesmentioning

confidence: 99%

Harmful effects of dietary salt in addition to hypertension

2002

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In addition to raising the blood pressure dietary salt is responsible for several other harmful effects. The most important are a number which, though independent of the arterial pressure, also harm the cardiovascular system. A high salt intake increases the mass of the left ventricle, thickens and stiffens conduit arteries and thickens and narrows resistance arteries, including the coronary and renal arteries. It also increases the number of strokes, the severity of cardiac failure and the tendency for platelets to aggregate. In renal disease, a high salt intake accelerates the rate of renal functional

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“…smoking, diabetes and osteoporosis) have been shown to affect bone density and healing. 8,9 Although the hypothesis that hypertension may have a harmful effect on bone density was previously evaluated in a series of animal and clinical studies, [10][11][12][13][14] to date, few investigations have focused on the influence of hypertension on bone healing. 15 Currently the hypothesis that the hypertension could lead to an increased incidence of late implant loss was evaluated by Alsaadi et al (2008).…”

Section: Introductionmentioning

confidence: 99%

Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

et al. 2010

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Abstract:Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.

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Bone disorders in spontaneously hypertensive rat

Cited by 79 publications

References 4 publications

Urinary calcium excretion, sodium intake and blood pressure in a multi-ethnic population: results of the Wandsworth Heart and Stroke Study

Urinary calcium excretion, sodium intake and blood pressure in a multi-ethnic population: results of the Wandsworth Heart and Stroke Study

Harmful effects of dietary salt in addition to hypertension

Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

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