Bone effects of metformin monotherapy and its combination with teneligliptin: A 12-week follow-up study in patients with type 2 diabetes mellitus

Shaik, Abdul Rahaman; Kohli, Sunil; Vohora, Divya

doi:10.1016/j.diabres.2024.111744

Diabetes Research and Clinical Practice

2024

DOI: 10.1016/j.diabres.2024.111744

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Bone effects of metformin monotherapy and its combination with teneligliptin: A 12-week follow-up study in patients with type 2 diabetes mellitus

Abdul Rahaman Shaik,

Sunil Kohli,

Divya Vohora

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Teneligliptin mitigates diabetic cardiomyopathy through inflammasome inhibition: Insights from experimental studies

Cheng,

Hao,

Liu

et al. 2024

World J Diabetes

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This article provides commentary on the article by Zhang et al . In this original research, Zhang et al investigated the therapeutic potential of teneligliptin for diabetic cardiomyopathy (DCM), which was mediated by targeting the NOD-like receptor protein 3 (NLRP3) inflammasome. Through the use of both in vivo and in vitro models, the study demonstrated that teneligliptin alleviates cardiac hypertrophy, reduces myocardial injury, and mitigates the inflammatory responses associated with DCM. These findings suggest that teneligliptin’s cardioprotective effects are mediated through the inhibition of NLRP3 inflammasome activation, positioning it as a promising therapeutic option for managing DCM in diabetic patients.

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Teneligliptin mitigates diabetic cardiomyopathy through inflammasome inhibition: Insights from experimental studies

Cheng,

Hao,

Liu

et al. 2024

World J Diabetes

View full text Add to dashboard Cite

show abstract

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Bone effects of metformin monotherapy and its combination with teneligliptin: A 12-week follow-up study in patients with type 2 diabetes mellitus

Cited by 1 publication

References 48 publications

Teneligliptin mitigates diabetic cardiomyopathy through inflammasome inhibition: Insights from experimental studies

Teneligliptin mitigates diabetic cardiomyopathy through inflammasome inhibition: Insights from experimental studies

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