Bone Formation Around Titanium Implants in the Rat Tibia: Role of Insulin

Abstract

Translations [German, Spanish, Portuguese, Japanese] AUTOR(EN):

Diabetes and Oral Implant Failure

“…This also leads to a greater predisposition to infection of the wound. Moreover, animal studies showed negative effects of hyperglycemia, not only on bone formation, but also on bone strength and fracture healing (Lu et al, 2003;Siqueira et al, 2003;Kayal et al, 2007). These effects are suggested to affect the osseointegration.…”

“…Animal studies have shown that uncontrolled diabetes hinders bone formation, bone remodeling, and wound healing (Nevins et al, 1998) and causes reduction in bone-to-implant contact (BIC) and bone thickness (Takeshita et al, 1998), while insulin upregulates bone formation (Siqueira et al, 2003) and maintains BIC (Kwon et al, 2005). The effects of a hyperglycemic state have been shown to include inhibition of osteoblastic cell proliferation and collagen production during the early stages of callus development, resulting in reduced bone formation as well as diminished mechanical properties of the newly formed bone (Lu et al, 2003).…”

“…Accordingly, diabetes remains a relative contraindication for implant therapy (Michaeli et al, 2009); that is, well-controlled diabetic patients may be considered appropriate for implant therapy, while diabetic patients lacking good glycemic control may be denied the benefits of implant therapy (Oates et al, 2013). Decreased levels of implant osseointegration have been demonstrated in hyperglycemic animals consistent with untreated type 1 diabetes (Siqueira et al, 2003;de Morais et al, 2009). However, the subject is contradictory, since numerous studies offer indirect evidence for diabetes patients benefiting from oral rehabilitation based on dental implant therapy.…”

Biological markers around immediately placed titanium implant in the extraction socket of diabetic and insulin-treated rat maxilla

“…It is asserted that induction of diabetes with streptozotocin has been associated with increased bone response compared to controls, yet this response was mediated by the treatment with insulin. Therefore, bone repair around endosseous implants appears to be regulated, at least in part, by insulin [15][16][17] . The above mentioned experimental studies demonstrated that the detrimental effects of diabetes on osseointegration can be modified using insulin.…”

“…Besides, to our knowledge, little is known about the tissue response to titanium implantation in the rat maxilla 18 and bone formation around immediately placed implants 19 . In addition, in most prior studies, the implants were placed in the long bones such as fibula and tibia of the rat 13,[15][16][17]20,21 . These sites provide an accessible site for implant placement in the rat model.…”