Bone formation enhanced by induction: Bone growth in titanium implants in rats

Rønningen, Helge; Solheim, Ludvig Fjeld; Langeland, Norvald

doi:10.3109/17453678508992983

Cited by 26 publications

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References 32 publications

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“…Biologic fixation has proved to be a viable alternative to acrylic bone cement (1,7,14,23). Indeed, many studies have reported progressive growth of bone into metal implants in experimental animals and humans (16,25). It became apparent that faster, initial stabilization of uncemented prosthetic components may Received October 23,1991; accepted February 17,1993.…”

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Enhancement of bone growth into metal screws implanted in the medullary canal of the femur in rats

Hazan

Oron

1993

Journal Orthopaedic Research

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The kinetics of growth of bone into control (nontreated) and heat-treated screws made of stainless steel (type 316L) and Ti-6Al-4V, implanted in the medullary canal of the femur in rats, were studied by mechanical, histological, and biochemical methods. A progressive and significant increase in the ingrowth of bone, as reflected by interfacial shear strengths of the screws, was measured with time after implantation. At all time intervals for as long as 35 days after implantation, the shear strength of the heat-treated Ti-6Al-4V and stainless-steel screws was significantly higher than (1.6-3.4 times) that of the control screws. The specific activity of alkaline phosphatase in extracts of tissue from around the implanted screws peaked 6 days after insertion, with significantly higher values at 5, 6, and 7 days postoperatively for the heat-treated screws than for the controls. The extent of calcification also was higher at all time intervals for the heat-treated screws than for the controls. The histological evaluation of formation of bone between the ridges of the implanted screw corroborated the mechanical and biochemical measurements. At each time interval, a more mature bone was noted around the heat-treated screws than around the controls. It was concluded that the heat treatment of metal implants before insertion can result in augmentation of osseous ingrowth 1.6-5.3 times that into control implants in an in vivo experimental model.

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Enhancement of bone growth into metal screws implanted in the medullary canal of the femur in rats

Hazan

Oron

1993

Journal Orthopaedic Research

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Breakdown corrosion potential of ceramic coated metal implants

Hayashi

Noda

Uenoyama

et al. 1990

J. Biomed. Mater. Res.

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The long-term success of joint replacement largely depends on the stable fixation of the implant to bone. Current methods rely on mechanical fixation either with or without the use of acrylic bone cement. The drawbacks of cement are well known' and the newer porous metal coatings are still under review.2r3Studies on composites in which metals are coated with ceramics have been reported recently as an alternative method of long-term fixati~n.~" We have devised hydroxyapatite (A) . alumina (B)titanium-nitride (C) (HAP . a-AlZO3 . TiN)-coated SUS-316L stainless steel and HAP (D) . titanium-oxide (E) (TiOJ-coated Ti-6A1-4V.

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Quantitative analysis of in vivo tissue responses to titanium‐oxide‐ and hydroxyapatite‐coated titanium alloy

Hayashi

Uenoyama

Matsuguchi

et al. 1991

J. Biomed. Mater. Res.

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We have previously studied a large number of histological specimens of biomaterials and found that regions with and without an intervening fibrous membrane coexisted in many specimens. Therefore, it appears necessary to perform an evaluation of the entire specimen when histologically assessing the affinity of bone for a biomaterial. Accordingly, we performed a quantitative histological evaluation of hydroxyapatite (HAP)- and titanium-oxide(TiO2)-coated Ti-6A1-4V and uncoated Ti-6A1-4V (control) by determining the affinity index. This was defined as the length of bone directly opposed to the implant/the total length of the bone-implant interface X 100%. The test materials were inserted into the distal epiphyseal region of the femurs of adult dogs, and follow-up quantitative histological comparisons were performed from 4 weeks to 96 weeks. The HAP-coated implants had the highest affinity index 4 weeks after insertion, and this superiority was maintained up to 96 weeks. There was a significant difference in affinity index between HAP-coated implants and control implants (P less than 0.001), while TiO2-coated implants showed no significant difference in comparison to the control.

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Bone formation enhanced by induction: Bone growth in titanium implants in rats

Cited by 26 publications

References 32 publications

Enhancement of bone growth into metal screws implanted in the medullary canal of the femur in rats

Enhancement of bone growth into metal screws implanted in the medullary canal of the femur in rats

Breakdown corrosion potential of ceramic coated metal implants

Quantitative analysis of in vivo tissue responses to titanium‐oxide‐ and hydroxyapatite‐coated titanium alloy

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