Bone formation in TiO2 bone scaffolds in extraction sockets of minipigs

Processing of highly porous TiO2 bone scaffolds with improved compressive strength

“…24 The excellent osteoconductive capacity of these TiO 2 scaffolds was attributed to the large and highly interconnected pore volume of the TiO 2 foam structure. However, as the mechanical properties of a scaffold are governed not only by the scaffold material but also by the pore architecture of the scaffold structure, increasing pore sizes and porosity are known to have a detrimental effect on the mechanical properties of cellular solids, and consequently reduce the structural integrity of the scaffold construct.…”

Bone Marrow-Derived Cell Concentrates Have Limited Effects on Osteochondral Reconstructions in the Mini Pig

“…This is remarkable, as other studies using different cell types such as chondrocytes, osteocytes, adipose-derived stem cells, mesenchymal stem cells (MSCs), transgenic cells, or platelet-rich plasma [28][29][30]33 showed significant benefits for the regeneration of meniscus, 4 cartilage, 31 or bone. 32,33 Although it seems that the efficacy of regeneration supporting cells or bioactive molecules is not present in all cases, the benefits of porous scaffolds for stabilizing the defects and for providing a simple matrix for ingrowing cells are repeatedly reported. [33][34][35] Obviously, the material the scaffolds are made of plays only a minor role, as different materials such as betatricalciumphosphate, 14 hyaluronic acid, and atelocollagen 10 or a combination of hydroxyapatite and beta-tricalcium phosphate showed comparable effects.…”

The effect of TiO2 nanopowder coating on in vitro bioactivity of porous TiO2 scaffolds

“…Thus interconnected porous structures are essential for the cell migration, bone tissue ingrowth, vascularisation and sufficient exchange of nutrients and waste [2]. TiO 2 ceramic scaffolds have attracted particular attention due to their excellent mechanical properties compared to the other ceramic materials, biocompatibility and good osteoconductivity [2,3].…”