Bone-forming pleomorphic adenoma of the upper lip: Report of a case

Hamakawa, Hiroyuki; Takarada, Manabu; Ito, Chizuru; Tanioka, Hiroaki

doi:10.1016/s0278-2391(97)90653-4

Cited by 11 publications

(14 citation statements)

References 8 publications

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“…However, bone formation in pleomorphic adenoma of the salivary gland is a rare finding 2,3 . Only several cases of pleomorphic adenoma in which most parts are occupied by bone tissues have been reported 4–10 …”

Section: Discussionmentioning

confidence: 99%

Pleomorphic adenoma of the parotid gland with extensive bone formation

Shigeishi¹,

Hayashi²,

Takata³

et al. 2001

Pathology International

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We report an unusual case of pleomorphic adenoma with extensive bone formation, occurring in the parotid gland of a 58-year-old Japanese man. The tumor was a well-circumscribed mass that measured 20 x 20 x 15 mm and contained extensive bone formation. Histologically, most of the tumor was composed of bone and chondroid tissues. The bone formation with a marrow-like structure occupied half the volume of the tumor. The chondroid tissues merged continuously into bone tissues. The bone tissue seemed to be formed within areas of chondral tissue by a process of enchondral ossification. Except for the unusual amount of large bone formation, the tumor showed histology of pleomorphic adenoma, particularly at the periphery of the tumor. These histological findings suggest the possibility of extensive enchondral ossification in pleomorphic adenoma.

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Section: Discussionmentioning

confidence: 99%

Pleomorphic adenoma of the parotid gland with extensive bone formation

Shigeishi¹,

Hayashi²,

Takata³

et al. 2001

Pathology International

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“…Although there are some case reports of bone formation in pleomorphic adenoma 2, 3, 6-9, Shigeishi et al 3 noted that bone formation in pleomorphic adenoma is a rare finding, and only several cases have been reported. Yates and Paget 9 described a case of pleomorphic adenoma of the submandibular gland with trabecular bone formation, and the bone was formed by endochondral ossification.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, Lee et al 7 mentioned in their case report of pleomorphic adenoma with bone formation that the bone matrix was deposited directly by the metaplastic myoepithelial cells rather than by endochondral ossification. Hamakawa et al 6 noted that bone tissue in pleomorphic adenoma was formed mainly by direct deposition of the osteoid tissue produced by the modified myoepithelial cells and via partial endochondral ossification mode. However, Takeda and Yamamoto 8 discussed bone formation mechanisms according to the histopathological findings of their bone forming pleomorphic adenoma case.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma

Nakano¹,

Watanabe²,

Shimizu³

et al. 2007

Int. J. Med. Sci.

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Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore, positive reaction was detected in the bone forming cells: osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells.

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“…From the previously reported cases, only a few cases of pleomorphic adenoma with osseous tissue have been reported, and the mechanism of osseous tissue formation in pleomorphic adenoma remains controversial (2–4). Yates & Paget reported a pleomorphic adenoma of the submandibular salivary glands that showed several areas of trabecular bone formation within areas of cartilage, considered to result from endochondral ossification (2).…”

Section: Commentsmentioning

confidence: 99%

“…Hamakawa et al. reported a bone‐forming pleomorphic adenoma of the upper lip that appeared to result from direct deposition of osteoid tissue by modified myoepithelial cells as well as partial endochondral ossification (4). In this case, the osseous tissue was observed within areas of chondroid tissue, so we suggested the osseous tissue formation via the process of endochondral ossification.…”

Section: Commentsmentioning

confidence: 99%

Pleomorphic adenoma of the submandibular salivary glands with marked ossification

Hui

Shimizu

Niki

et al. 2003

J Oral Pathology Medicine

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This article describes an unusual case of pleomorphic adenoma arising in the submandibular salivary glands that was associated with marked ossification. CT scan showed an irregular high-density mass in the left submandibular region. Histologic examination of the resected mass revealed a well-circumscribed pleomorphic adenoma with chondroid tissue intermingled with glandular and trabecular epithelial components. Irregularly formed osseous tissue was present in the chondroid tissue. The osseous tissue showed bone matrix on von Kossa's staining. Alkaline phosphatase expression was restricted to the vicinity of osseous tissue. Tartrate-resistant acid phosphatase-positive osteoclasts were observed at the periphery of the osseous tissue. CD34 staining demonstrated many microvascular vessels in both the chondroid and osseous tissues. We conclude the osseous tissue in pleomorphic adenoma was bone in nature, and via the process of endochondral ossification most likely depended on angiogenesis.

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Bone-forming pleomorphic adenoma of the upper lip: Report of a case

Cited by 11 publications

References 8 publications

Pleomorphic adenoma of the parotid gland with extensive bone formation

Pleomorphic adenoma of the parotid gland with extensive bone formation

Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma

Pleomorphic adenoma of the submandibular salivary glands with marked ossification

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