Bone fracture in severe small-for-gestational-age, extremely low birth weight infants: A single-center analysis

Maruyama, Hidehiko; Amari, Shoichiro; Fujinaga, Hideshi; Fujino, Shuhei; Nagasawa, Junko; Wada, Yuka; Tsukamoto, Keiko; Ito, Yushi

doi:10.1016/j.earlhumdev.2017.02.004

Cited by 7 publications

(6 citation statements)

References 23 publications

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“…Lower bone accretion in preterm infants born SGA than in infants born AGA, independent of body size, suggest that prenatal conditions for bone accretion may not be replicated postnatally [84]. Lower body weight in infants born SGA was suggested as a potential risk factor for fracture [85] and an increased predisposition for fracture as a result of lower peak bone mass and higher risk of osteopenia was reported in young adults born SGA [86]. A study involving 15 preterm infants born SGA suggested that they may be at increased risk of low bone mass in adult life [87], with some data supporting that early life weight gain, especially peak weight velocity may be related to bone health, as assessed by vertebral cross sectional area, in adult life [88].…”

Section: Bone Strengthmentioning

confidence: 99%

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

Darendelıler

Kandemir

Harris

et al. 2019

Journal of Pediatric Endocrinology and Metabolism

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BackgroundAn increasing body of evidence supports the view that both an adverse intrauterine milieu and rapid postnatal weight gain in children born small for gestational age (SGA) contribute towards the risk for the development of chronic diseases in adult life.ContentThe aim of this review was to identify and summarize the published evidence on metabolic and cardiovascular risk, as well as risk of impaired cardiac function, intellectual capacity, quality of life, pubertal development and bone strength among children born SGA. The review will then address whether growth hormone (GH) therapy, commonly prescribed to reduce the height deficit in children born SGA who do not catch up in height, increases or decreases these risks over time.SummaryOverall, there are limited data in support of a modest beneficial effect of GH therapy on the adverse metabolic and cardiovascular risk observed in short children born SGA. Evidence to support a positive effect of GH on bone strength and psychosocial outcomes is less convincing.OutlookFurther evaluation into the clinical relevance of any potential long-term benefits of GH therapy on metabolic and cardiovascular endpoints is warranted.

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Section: Bone Strengthmentioning

confidence: 99%

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

Darendelıler

Kandemir

Harris

et al. 2019

Journal of Pediatric Endocrinology and Metabolism

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“…Rickets and vitamin D deficiency are associated with bone fragility [14–16]. Suggested risk factors include further maternal smoking [17], twinning [18], and small-for-gestational age [19]. Potentially, maternal obesity [20] and ethnicity [21] could contribute to vitamin D deficiency and lower up-take of calcium and phosphorus.…”

Section: Introductionmentioning

confidence: 99%

Metabolic bone disease risk factors strongly contributing to long bone and rib fractures during early infancy: A population register study

Högberg¹,

Andersson²,

Högberg³

et al. 2018

PLoS ONE

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BackgroundThe aim of this study was to assess the incidence of fractures in infancy, overall and by type of fracture, its association with accidents, metabolic bone disease risk factors, and abuse diagnosis.MethodsThe design was a population-based register study in Sweden. Participants: Children born 1997–2014, 0–1 years of age diagnosed with fracture-diagnosis according to International Classification of Diseases (ICD10) were retrieved from the National Patient Register and linked to the Swedish Medical Birth Register and the Death Cause Register. Main outcome measures were fractures of the skull, long bone, clavicle and ribs, categorized by age (younger or older than 6 months), and accident or not.FindingsThe incidence of fractures during infancy was 251 per 100 000 infants (n = 4663). Major fracture localisations were long bone (44·9%), skull (31·7%), and clavicle (18·6%), while rib fractures were few (1·4%). Fall accidents were reported among 71·4%. One-third occurred during the first 6 months. Metabolic bone disease risk factors, such as maternal obesity, preterm birth, vitamin D deficiency, rickets, and calcium metabolic disturbances, had increased odds of fractures of long bones and ribs in early infancy (0–6 months): birth 32–36 weeks and long bone fracture [AOR 2·13 (95%CI 1·67–2·93)] and rib fracture [AOR 4·24 (95%CI 1·40–12·8)]. Diagnosis of vitamin D deficiency/rickets/disorders of calcium metabolism had increased odds of long bone fracture [AOR 49·5 (95%CI 18·3–134)] and rib fracture [AOR 617 (95%CI 162–2506)]. Fractures without a reported accident had higher odds of metabolic risk factors than those with reported accidents. Abuse diagnosis was registered in 105 infants, with overrepresentation of preterm births, multiple births and small-for-gestational age.InterpretationMetabolic bone disease risk factors are strongly associated with fractures of long bone and ribs in early infancy. Fracture cases with abuse diagnosis had a metabolic bone risk factor profile.

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“…Congenital, hereditary rickets may develop due to genetic disorders , foetal deficiency of vitamin D and intrauterine growth retardation . In addition, maternal obesity and ethnicity could potentially contribute to foetal vitamin D deficiency.…”

Section: Introductionmentioning

confidence: 99%

Population‐based register study of children born in Sweden from 1997 to 2014 showed an increase in rickets during infancy

2019

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Bone fracture in severe small-for-gestational-age, extremely low birth weight infants: A single-center analysis

Cited by 7 publications

References 23 publications

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

What is the evidence for beneficial effects of growth hormone treatment beyond height in short children born small for gestational age? A review of published literature

Metabolic bone disease risk factors strongly contributing to long bone and rib fractures during early infancy: A population register study

Population‐based register study of children born in Sweden from 1997 to 2014 showed an increase in rickets during infancy

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