Bone fragility in diabetes: novel concepts and clinical implications

Hofbauer, Lorenz C.; Busse, Björn; Eastell, Richard; Ferrari, Serge; Frost, Morten; Müller, Ralph; Burden, Andrea M.; Rivadeneira, Fernando; Napoli, Nicola; Rauner, Martina

doi:10.1016/s2213-8587(21)00347-8

Cited by 215 publications

(144 citation statements)

References 184 publications

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“…DM is able to cause damages to a variety of organs, in particular, nervous system, kidneys, and blood vessels. Substantial evidence suggests that a longer exposure to hyperglycemia also make an impact on bone metabolism (BM) (2,3). Initially, many clinicians observed that diabetic patients had a higher risk of fractures as well as impaired fracture healing.…”

Section: Introductionmentioning

confidence: 99%

“…remodeling (2). To date, despite more than 20 years of intensive research and several hypotheses, such as oxidant injury, accumulation of advanced glycation end products, increased collagen glycation, bone-fat axis hypothesis, and some other intermediate mediators including hormones, cytokines and nutrients, have been proposed, the specific mechanism of diabetes-related reduction of bone mass remains unclear (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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Mapping Knowledge Landscapes and Emerging Trends of the Links Between Bone Metabolism and Diabetes Mellitus: A Bibliometric Analysis From 2000 to 2021

Cheng

Guo

Yang

et al. 2022

Front. Public Health

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BackgroundDiabetes mellitus (DM) have become seriously threatens to human health and life quality worldwide. As a systemic metabolic disease, multiple studies have revealed that DM is related to metabolic bone diseases and always induces higher risk of fracture. In view of this, the links between bone metabolism (BM) and DM (BMDM) have gained much attention and numerous related papers have been published. Nevertheless, no prior studies have yet been performed to analyze the field of BMDM research through bibliometric approach. To fill this knowledge gap, we performed a comprehensive bibliometric analysis of the global scientific publications in this field.MethodsArticles and reviews regarding BMDM published between 2000 and 2021 were obtained from the Web of Science after manually screening. VOSviewer 1.6.16, CiteSpace V 5.8.R3, Bibliometrix, and two online analysis platforms were used to conduct the bibliometric and visualization analyses.ResultsA total of 2,525 documents including 2,255 articles and 270 reviews were retrieved. Our analysis demonstrated a steady increasing trend in the number of publications over the past 22 years (R2 = 0.989). The United States has occupied the leading position with the largest outputs and highest H-index. University of California San Francisco contributed the most publications, and Schwartz AV was the most influential author. Collaboration among institutions from different countries was relatively few. The journals that published the most BMDM-related papers were Bone and Osteoporosis International. Osteoporosis and related fractures are the main bone metabolic diseases of greatest concern in this field. According to co-cited references result, “high glucose environment,” “glycation end-product” and “sodium-glucose co-transporter” have been recognized as the current research focus in this domain. The keywords co-occurrence analysis indicated that “diabetic osteoporosis,” “osteoarthritis,” “fracture risk,” “meta-analysis,” “osteogenic differentiation,” “bone regeneration,” “osteogenesis,” and “trabecular bone score” might remain the research hotspots and frontiers in the near future.ConclusionAs a cross-discipline research field, the links between bone metabolism and diabetes mellitus are attracting increased attention. Osteoporosis and related fractures are the main bone metabolic diseases of greatest concern in this field. These insights may be helpful for clinicians to recognize diabetic osteopenia and provide more attention and support to such patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mapping Knowledge Landscapes and Emerging Trends of the Links Between Bone Metabolism and Diabetes Mellitus: A Bibliometric Analysis From 2000 to 2021

Cheng

Guo

Yang

et al. 2022

Front. Public Health

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“…Additionally, diabetic microvascular complications including neuropathy, retinopathy, and nephropathy are relevant to increased fracture risks ( 70 , 71 ). Therefore, drugs that can prevent or improve diabetic microvascular complications such as aspirin, angiotensin-converting enzyme inhibitors, statins may be of potential benefits to bone health under diabetic conditions ( 72 ).…”

Section: Drugsmentioning

confidence: 99%

“…LLLT can improve implant stability in patients with diabetes in 6 months trial ( 149 ). However, there is no clinical research evidence specifically designed to improve fracture healing in patients with diabetes ( 72 ). And at present, there is no direct proof in existing clinical trials that the abovementioned methods have beneficial effects in improving bone healing under diabetic conditions.…”

Section: Challenges and Prospectsmentioning

confidence: 99%

Challenges to Improve Bone Healing Under Diabetic Conditions

2022

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Diabetes mellitus (DM) can affect bone metabolism and the bone microenvironment, resulting in impaired bone healing. The mechanisms include oxidative stress, inflammation, the production of advanced glycation end products (AGEs), etc. Improving bone healing in diabetic patients has important clinical significance in promoting fracture healing and improving bone integration. In this paper, we reviewed the methods of improving bone healing under diabetic conditions, including drug therapy, biochemical cues, hyperbaric oxygen, ultrasound, laser and pulsed electromagnetic fields, although most studies are in preclinical stages. Meanwhile, we also pointed out some shortcomings and challenges, hoping to provide a potential therapeutic strategy for accelerating bone healing in patients with diabetes.

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“…However, the concept of diabetic complications has become extensive and complicated [1]. For instance, bone disorders have been drawing attention as a novel diabetic complication, and accumulating evidence supports that diabetes is associated with an increased risk of osteoporotic fracture [2][3][4][5][6][7][8][9]. To date, numerous efforts have been made to predict, prevent, and treat both diabetes and diabetic complications.…”

Section: Introductionmentioning

confidence: 99%

The Role of Bone-Derived Hormones in Glucose Metabolism, Diabetic Kidney Disease, and Cardiovascular Disorders

Yuasa

Kawanami

2022

IJMS

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Bone contributes to supporting the body, protecting the central nervous system and other organs, hematopoiesis, the regulation of mineral metabolism (mainly calcium and phosphate), and assists in respiration. Bone has many functions in the body. Recently, it was revealed that bone also works as an endocrine organ and secretes several systemic humoral factors, including fibroblast growth factor 23 (FGF23), osteocalcin (OC), sclerostin, and lipocalin 2. Bone can communicate with other organs via these hormones. In particular, it has been reported that these bone-derived hormones are involved in glucose metabolism and diabetic complications. Some functions of these bone-derived hormones can become useful biomarkers that predict the incidence of diabetes and the progression of diabetic complications. Furthermore, other functions are considered to be targets for the prevention or treatment of diabetes and its complications. As is well known, diabetes is now a worldwide health problem, and many efforts have been made to treat diabetes. Thus, further investigations of the endocrine system through bone-derived hormones may provide us with new perspectives on the prediction, prevention, and treatment of diabetes. In this review, we summarize the role of bone-derived hormones in glucose metabolism, diabetic kidney disease, and cardiovascular disorders.

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Bone fragility in diabetes: novel concepts and clinical implications

Cited by 215 publications

References 184 publications

Mapping Knowledge Landscapes and Emerging Trends of the Links Between Bone Metabolism and Diabetes Mellitus: A Bibliometric Analysis From 2000 to 2021

Mapping Knowledge Landscapes and Emerging Trends of the Links Between Bone Metabolism and Diabetes Mellitus: A Bibliometric Analysis From 2000 to 2021

Challenges to Improve Bone Healing Under Diabetic Conditions

The Role of Bone-Derived Hormones in Glucose Metabolism, Diabetic Kidney Disease, and Cardiovascular Disorders

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