Bone Grafting and Bone Graft Substitutes

Kaveh, Kamran; Ibrahim, Rashid; Zuki, A. B. Mohd; Ibrahim, Tengku Azmi Tengku

doi:10.3923/javaa.2010.1055.1067

Cited by 31 publications

(38 citation statements)

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“…Moreover, it decreased MPO and ALP release by neutrophils in all measurements. The obtained results indicated that PR-39 inhibited secretory activity of neutrophils except for elastase release, which is essential in the first phase of injury (Kaveh et al, 2010).…”

Section: Discussionmentioning

confidence: 79%

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The influence of porcine cathelicidins on neutrophils isolated from rabbits in the course of bone graft implantation

et al. 2013

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Antimicrobial peptides are important elements of host defence because of their direct antimicrobial activity and modulatory role in innate immune response. The purpose of the study was to determine whether porcine peptides PR-39, protegrins (PGs) and low molecular weight extract (LMWE) are able to influence the neutrophil response during bone graft implantation in rabbits. The study was conducted on 10 White New Zealand rabbits and neutrophil activity was assayed on the basis of elastase, myeloperoxidase, and alkaline phosphatase release as well as free radical generation. Our study showed that PR-39 and PGs inhibited enzyme release from neutrophils except for elastase, which is essential in the first phase of injury. Superoxide and nitric oxide generation under the influence of PR-39 and PGs were also decreased. Moreover, we found that unlike separated peptides PR-39 and PGs, LMWE acts proinflammatorily, intensifying the neutrophil secretory response and free radical generation. These results should be taken into account in treatment with natural antimicrobial peptides. The increased neutrophil responses in the first phase of inflammation during surgery may be useful in prevention of infection, but LMWE should not be used in conditions in which excessive neutrophil response is injurious.

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Section: Discussionmentioning

confidence: 79%

“…Similarly, in the first phase of bone graft incorporation during the first 18 h, the arrival of chemotactic factors and an accumulation of neutrophils as inflammatory cells are observed. This process is connected with elastase release and generation of inflammatory factors such as collagenous and fibronectin peptides (Kaveh et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The influence of porcine cathelicidins on neutrophils isolated from rabbits in the course of bone graft implantation

et al. 2013

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“…In the first phase of bone graft incorporation, during the first 18 h a chemotactic factor arrival and an accumulation of neutrophils as inflammatory cells are observed. This process is connected with elastase release producing chemotactic factors such as collagenous and fibronectin peptides (Kaveh et al, 2010). Immediately following injury, neutrophils migrate toward the implant site and this recruitment is triggered by chemoattractants.…”

Section: Discussionmentioning

confidence: 99%

The influence of porcine prophenin on neutrophils isolated from rabbit blood during implantation of calcium sulphate graft material into bone tissue

2012

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ABSTRACT:Immune dysfunction induced by surgical trauma may comprise either an inappropriately exaggerated inflammatory response or a profound suppression of cell-mediated immunity. Neutrophils are the leading cells in the first response to trauma. It is known that they mediate initial resistance to bacterial infection. Activated neutrophils can degranulate and release some enzymes such as elastase and myeloperoxidase (MPO). The function of elastase is, among others, to kill bacterial, whereas MPO is a specific enzyme of primary granules of neutrophils and a marker of in vivo neutrophil activation. Previous reports estimated that some cathelicidins could act to increase or diminish an innate immune response in which neutrophils participate. The aim of this study was to evaluate prophenins (PF) isolated from porcine leukocytes in respect to neutrophil activity and survival during implantation of calcium sulphate bone grafts substitution in rabbits. Obtained results pointed out that neutrophils responded to PF depending upon concentration. Thirty min from implantation of calcium sulphate graft, we observed the greatest release of elastase (57.01±0.49% of maximal release) in cultures stimulated with 10 mg/mL of PF, at 0 mg/mL was 51.15±0.23%, while after 24 h of incubation the greatest response was at a concentration of 20 mg/mL. MPO release after 30 min from surgery decreased significantly at 10 mg/mL. In higher concentrations, the inhibition was less pronounced. Moreover, we estimated that PF causes cytotoxicity in the highest concentration as well as the apoptosis of neutrophils.

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“…При всех успехах трансплантации кости нельзя не отметить, что далеко не всегда оперативное вмешательство, необходимое для взятия аутотрансплантата, бывает оправдано, так как при этом вызывается дополнительная травма донорского участка ор-ганизма, а основным недостатком аллотрансплантации, до на-стоящего времени считавшейся более перспективной, является проблема иммунной совместимости материала донора и реципи-ента [3][4][5][6][7][8][9]. В последние годы значительное внимание уделяется созда-нию керамических материалов медицинского назначения, пред-назначенных для использования при реконструкции дефектов костных тканей, образующихся в результате патологических из-менений в организме, обширных хирургических вмешательств или травм.…”

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Reconstruction of maxillofacial bone defect with a complex individual composite endoprosthesis: A clinical case

Решетов¹,

Sergeeva²,

Polyakov³

et al. 2014

Onkol. Z. im. P.A. Gercena

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Reconstruction of maxillofacial bone defect with a complex individual composite endoprosthesis:A clinical case i.v. reShetov, n.S. SerGeevA, A.p. polyAKov, M.M. filyuShin, o.v. MAtorin, M.v. rAtuShnyi, v.n. vASilyev p.A. herzen Moscow oncology research institute, Ministry of health of russia, Moscow разработана модель замещения дефектов кости биокерамическими гранулами на основе кальций-фосфатных соединений. Определена возможность применения кальций-фосфатной керамики для замещения костных дефектов в черепно-челюст-но-лицевой хирургии. представлено наблюдение реконструкции костного дефекта челюстно-лицевой зоны сложным ком-позитным эндопротезом. Ключевые слова: реконструкция, костный дефект, челюстно-лицевая зона, кальций-фосфатная керамика.A model was created to replace bone defects with calcium-phosphate-based bioceramic granules. Whether calcium-phosphatebased ceramics may be used to replace bone defects in craniomaxillofacial surgery was defined. the paper describes a case of reconstruction of maxillofacial bone defect with a complex composite endoprosthesis.

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Bone Grafting and Bone Graft Substitutes

Cited by 31 publications

References 0 publications

The influence of porcine cathelicidins on neutrophils isolated from rabbits in the course of bone graft implantation

The influence of porcine cathelicidins on neutrophils isolated from rabbits in the course of bone graft implantation

The influence of porcine prophenin on neutrophils isolated from rabbit blood during implantation of calcium sulphate graft material into bone tissue

Reconstruction of maxillofacial bone defect with a complex individual composite endoprosthesis: A clinical case

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