Bone Healing Evaluation Following Different Osteotomic Techniques in Animal Models: A Suitable Method for Clinical Insights

Anesi, Alexandre; Bartolomeo, Mattia Di; Pellacani, Arrigo; Ferretti, Marzia; Cavani, Francesco; Salvatori, Roberta; Nocini, Riccardo; Palumbo, Carla; Chiarini, Luigi

doi:10.3390/app10207165

Cited by 29 publications

(26 citation statements)

References 111 publications

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“…For this reason, it is crucial to determine the timing of the transition between SO and DO in post-surgical and implant behavior in order to establish when poor-quality bone can be loaded after reinforcement/replacement with bone actually capable of resisting mechanical loading has taken place. The aspects concerning inductive/mechanical stimuli and bone texture quality also acquire particular importance during healing of cranial linear osteotomies with different devices; this has been experimentally induced in rabbits to test the validity of traditional procedures versus piezosurgery [41,42]: the observations with regard to bone gap healing are in line with our previous observations [7] on the steps occurring in a sequence during bone histogenesis.…”

Section: Experimental Evidence For So and Do Occurrencesupporting

confidence: 58%

Static Osteogenesis versus Dynamic Osteogenesis: A Comparison between Two Different Types of Bone Formation

Ferretti

Palumbo

2021

Applied Sciences

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In contrary to what has traditionally been believed, bone formation can occur through two different types of osteogenesis: static (SO) and dynamic (DO) osteogenesis, which are thus named because the former is characterized by pluristratified cords of unexpectedly stationary osteoblasts which differentiate at a fairly constant distance from the blood capillaries and transform into osteocytes without moving from the onset site, while the latter is distinguished by the well-known typical monostratified laminae of movable osteoblasts. The two types of osteogenesis differ in multiple aspects from both structural and functional viewpoints. Besides osteoblast arrangement, polarization, and motion, SO and DO differ in terms of time of occurrence (first SO and later DO), conditioning factors to which they are sensitive (endothelial-derived cytokines or mechanical loading, respectively), distribution of osteocytes to which they give rise (haphazard or ordered in planes, respectively), the collagen texture resulting from the different deposition types (woven or lamellar, respectively), the mechanical properties of the bone they form (poor for SO due to the high cellularity and woven texture and good for DO since osteocytes are located in more suitable conditions to perceive loading), and finally the functions of each, i.e., SO provides a preliminary rigid scaffold on which DO can take place, while DO produces bone tissue according to mechanical/metabolic needs..

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Section: Experimental Evidence For So and Do Occurrencesupporting

confidence: 58%

Static Osteogenesis versus Dynamic Osteogenesis: A Comparison between Two Different Types of Bone Formation

Ferretti

Palumbo

2021

Applied Sciences

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“…Given the delicacy of the osteotomies performed, the use of the piezosurgical scalpel (Piezosurgery ® , Mectron Medical Technology, Carasco, Italy) was preferred owing to its better impact on bone healing dynamics [30,31].…”

Section: Discussionmentioning

confidence: 99%

A Case Report of a Solitary Fibrous Tumor of the Maxillary Sinus

Bartolomeo

Negrello

Pellacani

et al. 2021

Reports

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A solitary fibrous tumor (SFT) is a benign neoplasm, firstly described as a mesenchymal tumor of the pleura. Its incidence range in the head and neck region is about 5–27%, but only rarely does it affect paranasal sinuses. The differential diagnosis is challenging, owing to its erosive growth pattern and immuno-histochemical features. SFTs have an aggressive behavior and an important recurrence potential. Therefore, a radical surgical excision is the gold standard therapeutic procedure. A rare SFT originating from the right maxillary sinus is reported here. The 37-year-old patient presented to the outpatient clinic with a painful expansive lesion in the whole right maxillary region. The overlying skin was inflamed and the patient had no epistaxis episodes. The 1.5 dentary element tested negative for vitality; however, a puncture of the lesion led to a hematic spill and no purulent discharge. An endoscopic-guided biopsy was suggestive either of SFT or hemangioperictoma, excluding a malignant neoplasm. A multi-equipe surgical team was activated. The lesion was embolized in order to achieve a good hemostatic control and, after 48 h, the neoplasm was radically excised with a combined open and endoscopic approach. The patient was disease-free at 12-month radiological and clinical follow-up. Given the rarity of this lesion and the delicacy required in addressing head and neck neoplasms, we believe that the present case report might be of help in further understanding how to approach cranio-facial SFTs.

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“…Mandibular premolars (P1-P4) and M1 molar were extracted after full mouth scaling. Implants were placed after extraction sites had healed for 8 weeks [28,29]. General anesthesia and local infiltration anesthesia were applied as described for extractions.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Effects of Gamma Radiation-Induced Crosslinking of Collagen Type I Coated Dental Titanium Implants on Osseointegration and Bone Regeneration

et al. 2021

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This study aimed to compare two methods of crosslinking collagen type I on implanted titanium surfaces, that is, using glutaraldehyde (GA) or gamma-rays (GRs), in a beagle dog model. For in vivo experiments, implants were allocated to three groups and applied to mandibular bone defects in beagle dogs; Group SLA; non-treated Sandblasted, large grit, acid-etched (SLA) implants, Group GA; SLA implants coated with GA crosslinked collagen type I, Group GR; SLA surface implants coated with collagen type I and crosslinked using 25 kGy of 60Co gamma radiation. New bone μCT volumes were obtained, and histologic and histometric analyses were performed in regions of interest. The GR group had significantly better new bone areas (NBAs) and bone to implant contact (BIC) results than the SLA group (p < 0.05), but the GA and GR groups were similar in this respect. New bone volumes and inter-thread bone densities (ITBD) were non-significantly different in the three groups (p > 0.05). Within the limits of this study, gamma-ray collagen crosslinking on titanium implants can be considered a substitute for glutaraldehyde crosslinking.

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Bone Healing Evaluation Following Different Osteotomic Techniques in Animal Models: A Suitable Method for Clinical Insights

Cited by 29 publications

References 111 publications

Static Osteogenesis versus Dynamic Osteogenesis: A Comparison between Two Different Types of Bone Formation

Static Osteogenesis versus Dynamic Osteogenesis: A Comparison between Two Different Types of Bone Formation

A Case Report of a Solitary Fibrous Tumor of the Maxillary Sinus

Effects of Gamma Radiation-Induced Crosslinking of Collagen Type I Coated Dental Titanium Implants on Osseointegration and Bone Regeneration

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