Bone health in children and adolescents

Purpose The most safe and effective dose of vitamin D supplementation for healthy adolescents is currently unknown. The aim of this study was to compare the efficacy of 200 IU vs. 1000 IU of daily vitamin D3 for supplementation in healthy adolescents with baseline vitamin D sufficiency. Methods We conducted a double-blind, randomized clinical trial. Fifty-six subjects, ages 11–19 years, with baseline vitamin D sufficiency received 1000 IU or 200 IU of daily vitamin D3 for 11 weeks. Compliance was assessed using MEMS6 Trackcaps and pill counts. Results Fifty-three subjects completed the clinical trial. Subjects in the two treatment arms were similar in terms of age, race, gender, BMI, and dietary calcium and vitamin D intake. Serum 25(OH)D level in the 200 IU treatment arm was 28.1 ± 6.2 ng/mL at baseline (mean ± SD) and 28.9 ± 7.0 ng/mL at follow-up. In the 1000 IU treatment arm, 25(OH)D levels were 29.0 ± 7.3 and 30.1 ± 6.6 at baseline and follow-up, respectively. Mean change in 25(OH)D level did not differ significantly between treatment arms (p=0.87), nor did mean change in PTH, calcium, phosphate, bone turnover markers, fasting glucose, or fasting insulin. Conclusions In healthy adolescents with baseline vitamin D sufficiency, supplementation with vitamin D3 doses of 200 and 1000 IU for 11 weeks did not increase serum 25(OH)D levels, with no significant difference observed between treatment arms.

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Evaluation of bone density in children

Gordon

2005

Current Opinion in Endocrinology & Diabetes

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Bone health in children and adolescents

Cited by 3 publications

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Bone Structure, Growth, and Hormonal Regulation

Bone Structure, Growth, and Hormonal Regulation

A Randomized Clinical Trial of Vitamin D Supplementation in Healthy Adolescents

Evaluation of bone density in children

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