Bone health in children and youth with ASD: a systematic review and meta-analysis

Abadi, Mahdi Rostami Haji; Neumeyer, Ann M.; Misra, Madhusmita; Kontulainen, Saija

doi:10.1007/s00198-021-05931-5

Cited by 22 publications

(10 citation statements)

References 38 publications

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“…This difference may be associated with higher (Broder-Fingert et al 2014;Curtin et al 2005;Egan et al 2013;Matheson and Douglas 2017). In addition, lower daily MVPA may be related to bone deficits in children with ASD (Rostami Haji Abadi et al 2021), as daily minutes of MVPA has been positively associated with bone health in childhood and adolescence (Bland et al 2020;Kehrig et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Children with Autism Spectrum Disorder Spent 30 Min Less Daily Time in Moderate-to-Vigorous Physical Activity than Typically Developing Peers: a Meta-Analysis of Cross-sectional Data

Abadi

Zheng

Wharton

et al. 2021

Rev J Autism Dev Disord

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It remains unclear if participation in moderate-to-vigorous physical activity (MVPA) differs between children with ASD and typically developing children (TDC). We compared daily MVPA, time spent in MVPA during physical education (PE) and recess, and odds of not meeting MVPA recommendation (60 min/day) between children with ASD and TDC. Nine studies reporting accelerometer-measured MVPA were included in the meta-analyses. MVPA was 30 min lower/day, 12% and 8% lower during PE and recess, respectively, in children with ASD, and they had 4 times higher odds of not meeting MVPA recommendation when compared to TDC. Children with ASD engage in daily MVPA less than TDC and below the guidelines. Tailored interventions to increase MVPA in children with ASD are warranted.

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Section: Discussionmentioning

confidence: 99%

Children with Autism Spectrum Disorder Spent 30 Min Less Daily Time in Moderate-to-Vigorous Physical Activity than Typically Developing Peers: a Meta-Analysis of Cross-sectional Data

Abadi

Zheng

Wharton

et al. 2021

Rev J Autism Dev Disord

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“…In the context of ASD, children typically engage in less physical activity, have a lower BMI, and may not consume adequate amounts of calcium and calories [72,73]. These factors collectively increase the risk of low bone density in individuals with ASD [15,74]. For ADHD, various factors contribute to injuries and fractures in affected children.…”

Section: Ndds As Causal Factorsmentioning

confidence: 99%

“…Research consistently reveals distinctive patterns in bone health among individuals with ASD, including reduced systemic bone mineral content, diminished cortical area, and thinning of cortical and trabecular bone structures, especially in the distal radius and tibia. These trends extend to various anatomical regions, such as the lumbar spine, hips, and femoral neck, setting individuals with ASD apart from those without the condition [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study

Li,

Wu,

et al. 2024

BMC Psychiatry

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Background Neurodevelopmental disorders (NDDs), such as Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Tourette Syndrome (TS), have been extensively studied for their multifaceted impacts on social and emotional well-being. Recently, there has been growing interest in their potential relationship with fracture risks in adulthood. This study aims to explore the associations between these disorders and fracture rates, in order to facilitate better prevention and treatment. Methods Employing a novel approach, this study utilized Mendelian randomization (MR) analysis to investigate the complex interplay between ADHD, ASD, TS, and fractures. The MR framework, leveraging extensive genomic datasets, facilitated a systematic examination of potential causal relationships and genetic predispositions. Results The findings unveil intriguing bidirectional causal links between ADHD, ASD, and specific types of fractures. Notably, ADHD is identified as a risk factor for fractures, with pronounced associations in various anatomical regions, including the skull, trunk, and lower limbs. Conversely, individuals with specific fractures, notably those affecting the femur and lumbar spine, exhibit an increased genetic predisposition to ADHD and ASD. In this research, no correlation was found between TS and fractures, or osteoporosis.These results provide a genetic perspective on the complex relationships between NDDs and fractures, emphasizing the importance of early diagnosis, intervention, and a holistic approach to healthcare. Conclusion This research sheds new light on the intricate connections between NDDs and fractures, offering valuable insights into potential risk factors and causal links. The bidirectional causal relationships between ADHD, ASD, and specific fractures highlight the need for comprehensive clinical approaches that consider both NDDs and physical well-being.

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“…Compared to typically developing children, a meta-analysis found that children with ASD had up to 13% lower bone mineral density of the total body, which is associated with increased risk of fractures (Ref. 135 ). Osteoporosis and fracture are also associated with dysregulated phosphate metabolism in CKD-mineral and bone disease (CKD-MBD) (Ref.…”

Section: Asd Vitamin D Bone Disorders and Cardiovascular Diseasementioning

confidence: 99%

Dysregulated phosphate metabolism in autism spectrum disorder: associations and insights for future research

Brown

2023

Expert Rev. Mol. Med.

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Studies of autism spectrum disorder (ASD) related to exposure to toxic levels of dietary phosphate are lacking. Phosphate toxicity from dysregulated phosphate metabolism can negatively impact almost every major organ system of the body, including the central nervous system. The present paper used a grounded theory-literature review method to synthesise associations of dysregulated phosphate metabolism with the aetiology of ASD. Cell signalling in autism has been linked to an altered balance between phosphoinositide kinases, which phosphorylate proteins, and the counteracting effect of phosphatases in neuronal membranes. Glial cell overgrowth in the developing ASD brain can lead to disturbances in neuro-circuitry, neuroinflammation and immune responses which are potentially related to excessive inorganic phosphate. The rise in ASD prevalence has been suggested to originate in changes to the gut microbiome from increasing consumption of additives in processed food, including phosphate additives. Ketogenic diets and dietary patterns that eliminate casein also reduce phosphate intake, which may account for many of the suggested benefits of these diets in children with ASD. Dysregulated phosphate metabolism is causatively linked to comorbid conditions associated with ASD such as cancer, tuberous sclerosis, mitochondrial dysfunction, diabetes, epilepsy, obesity, chronic kidney disease, tauopathy, cardiovascular disease and bone mineral disorders. Associations and proposals presented in this paper offer novel insights and directions for future research linking the aetiology of ASD with dysregulated phosphate metabolism and phosphate toxicity from excessive dietary phosphorus intake.

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Bone health in children and youth with ASD: a systematic review and meta-analysis

Cited by 22 publications

References 38 publications

Children with Autism Spectrum Disorder Spent 30 Min Less Daily Time in Moderate-to-Vigorous Physical Activity than Typically Developing Peers: a Meta-Analysis of Cross-sectional Data

Children with Autism Spectrum Disorder Spent 30 Min Less Daily Time in Moderate-to-Vigorous Physical Activity than Typically Developing Peers: a Meta-Analysis of Cross-sectional Data

Complex interplay of neurodevelopmental disorders (NDDs), fractures, and osteoporosis: a mendelian randomization study

Dysregulated phosphate metabolism in autism spectrum disorder: associations and insights for future research

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