Bone health status of postmenopausal Chinese women

Lo, Stephen T.H.

doi:10.12809/hkmj154527

Cited by 12 publications

(19 citation statements)

References 21 publications

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“…7,8,9 While on the contrary in our study age doesn't seem to significantly affect the BMD which might be due to narrow range of age of the participants (40-60 years) included in our study.…”

Section: Discussioncontrasting

confidence: 72%

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Risk factors influencing the bone health in perimenopausal and postmenopausal women

Hooda

Upadhyay

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONOsteoporosis is a progressive skeletal disease manifested by decreased bone mineral density and collateral damage to the bone microarchitecture, which can subsequently lead to impaired skeletal strength and elevated susceptibility to fractures.1 It is a common and complex health problem in the elderly women. It has been statistically observed that over 50% of the adults at age 50 years or older suffer from osteoporosis, among which approximately 70% are postmenopausal females.2 BMD has been widely accepted as a surrogate parameter for the diagnosis of osteopenia and osteoporosis which supports its utility as a diagnostic avenue for abnormal bone mass.3 Many reproductive and menstrual factors like parity, breastfeeding, age at first pregnancy, age at menarche, use of combined oral contraceptives (COCs) and duration of menopause might influence the risk of osteoporosis. Our aim was to investigate the correlation of these factors with the BMD of postmenopausal women and in women undergoing menopause transition phase. Firstly, it will help in reducing the unnecessary BMD testing in elderly women and secondly, it will help in prevention of osteoporosis by helping the clinician to assess the need for early intervention. ABSTRACTBackground: Bone loss is being increasingly identified in premenopausal and early postmenopausal women. The significance of low bone mineral density (BMD) in females needs to be addressed. Female reproductive system plays a major role in regulating the bone loss from menarche to senescence. The purpose of our study is to identify the menstrual and reproductive factors that may lead to decreased bone mass during the premenopausal period so that early intervention could lead to improved bone health. Methods: The study was conducted on 100 women aged 40 -60 years attending the outpatient department in Pandit Bhagwat Dayal Sharma PGIMS, Rohtak, Haryana, India. Their age, parity, body mass index, age at menarche, age at first pregnancy, duration of breast feeding, use of combined oral contraceptive, interpregnancy interval and BMD values were recorded. BMD was measured by dual-energy x-ray absorptiometry. Pearson test was used for correlation analysis. Comparison between the groups was conducted using analysis of variance (ANOVA) and Tukey's test. Results: A significant negative correlation was established between parity, age at menarche, duration of breast feeding and BMD values. On the other hand, BMI and duration of oral contraceptive use showed a significant positive correlation with BMD values. Conclusions: Identification of risk factors for low BMD will provide the opportunity for early intervention to preventosteoporosis and will reduce the burden of unnecessary BMD testing in elderly age group for screening of osteoporosis.

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Section: Discussioncontrasting

confidence: 72%

“…8,15 This is due to sudden drop of ovarian estrogen around menopause. Accelerated bone loss begins about 2 to 3 years before the last menses and continues until 3 to 4 years after menopause.…”

Section: Discussionmentioning

confidence: 99%

Risk factors influencing the bone health in perimenopausal and postmenopausal women

Hooda

Upadhyay

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…Nonetheless, they have a higher fracture risk [18]. Another important finding reflected by the current study is the agreed upon fact regarding the inverse relation between age and BMD in cases of osteopenia and osteoporosis [19-21] which is likely attributed to the mobilization of calcium from bone. According to the present study, the advancement in age increased the likelihood of osteopenia and osteoporosis with an odds-ratio of 1.1.…”

Section: Discussionmentioning

confidence: 51%

The Prevalence and Risk Factors of Osteoporosis among a Saudi Female Diabetic Population

Al-Homood¹,

Sheshah²,

Mohammed³

et al. 2017

Open Access Maced J Med Sci

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AIM:This study aimed to assess the prevalence and determinants of osteoporosis [lumbar spine (LS) and femoral neck (FN)] among patients with type 2 diabetes at King Salman Hospital.MATERIALS AND METHODS:One hundred seventy patients with type 2 diabetes were enrolled in this cross-sectional study in the period from the 1st of January until the 1st of July 2015. Patient selection was based on self-report of the previous diagnosis by a physician, being on an antidiabetic agent, or a fasting glucose of 126 mg/dl as per the American Diabetes Association criteria. A dual energy X-ray absorptiometry scan with the bone mineral density (BMD) categorization based on the WHO cut of levels of T-scores and determination of vitamin D levels were performed. A detailed questionnaire was used to collect demographic data.RESULTS:Out of 170 participants, 50 (29.4%) were diagnosed as having osteoporosis, while 68 (40%) were diagnosed with osteopenia. Age was determined as a risk factor for a decreased BMD in patients with osteopenia (odds ratio (OR) = 1.1, 95% confidence interval (CI) = (1.0-1.1), p = 0.039) and osteoporosis (OR = 1.1, CI = 1.0-1.2, p < 0.001). Similarly, oral hypoglycemic agents (OHA) increased the risk of decreased BMD in osteopenia (OR = 2.6; CI = 1.0-6.7; p = 0.023) as well as osteoporosis, (OR = 3.8; CI = 1.3-10.9; p = 0.013), while vitamin D deficiency increased the risk of osteopenia OR = 3.0; CI = 1.2-7.2; p = 0.012). Increased BMI decreased the risk of both osteopenia and osteoporosis (OR = 0.9; CI = 0.9-0.99; p = 0.031 vs. OR = 0.9; CI = 0.80-0.95; p = 0.003).CONCLUSION:Advanced age, OHA and vitamin D deficiency are determinants of decreased BMD in Saudi women with type 2 diabetes, while an increased BMI protects against low BMD.

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“…The primary outcomes of interest in this review were: (1) Menopausal symptoms (39-47); (2) sexual functioning (43,44,(48)(49)(50)(51)(52); (3) health indicators and health behaviors (41,(53)(54)(55); and (4) health-related quality of life (41,43,52,56). Secondary outcomes of interest included physical performance and cognitive functioning (57,58); attitudes toward menopause (45,59); and the age and prevalence of natural menopause (42,60).…”

Section: Inadequate/lowmentioning

confidence: 99%

“…Two studies -one randomized controlled trial (51) and one functional magnetic resonance study (57) -included 100 women or fewer. In nine studies, the number of participants ranged between 246 and 389 (39,41,43,45,46,48,50,58,59), while five studies included 745-1774 women (44,47,52,53,55), and six studies enrolled more than 2020 women (40,42,49,54,56,60). Of these, three studies had more than 20,000 participants.…”

Section: Description Of Eligible Studiesmentioning

confidence: 99%

Determinants of menopause-related symptoms in women during the transition to menopause and the postmenopausal period – A systematic literature review

Pajalić

Raboteg-Šarić

2020

JHSCI

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Introduction: Menopause is a complex physiological, self-perceived health condition caused by the reduction and termination of ovarian function, a process that results in a range of both psychological and physiological symptoms. The aim of this literature review was to synthesize the results of published studies on factors associated with menopausal symptoms in women during the transition to menopause and the postmenopausal period.Methods: This systematic review was carried out according to the PRISMA statement. Primary studies published between 2007 and 2017 were identified through the following databases: PUBMED, SCOPUS, and CINAHL. In total, 3301 studies were identified and 279 were screened in full text. Of these, 54 studies were included for quality assessment using checklists from the Norwegian Institute for Public Health. A total of 22 studies were ultimately selected for inclusion in the results. These were thematically reviewed.Results: A wide range of determinants was sorted as socio-demographic predictors, reproductive factors, clinical characteristics, behavioral, and lifestyle characteristics, and their association with the following outcomes was examined: The prevalence and severity of menopausal symptoms; sexual functioning; health indicators and health behaviors; health-related quality of life; physical performance; cognitive changes and attitudes; and the prevalence and age of natural menopause.Conclusions: The current state of knowledge regarding menopause indicates that a wide array of instruments and variables have been employed and assessed to further understanding about menopause-related symptoms. This systematic review provides information on factors that should be considered in the treatment of menopause-related changes that may be bothersome for menopausal women.

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Bone health status of postmenopausal Chinese women

Cited by 12 publications

References 21 publications

Risk factors influencing the bone health in perimenopausal and postmenopausal women

Risk factors influencing the bone health in perimenopausal and postmenopausal women

The Prevalence and Risk Factors of Osteoporosis among a Saudi Female Diabetic Population

Determinants of menopause-related symptoms in women during the transition to menopause and the postmenopausal period – A systematic literature review

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