Bone health status of premenopausal healthy adult females in Pakistani females

Dar, Farhan Javed; Iqbal, Romaina; Ghani, Farooq; Siddiqui, Imran; Khan, Aysha Habib

doi:10.1007/s11657-012-0085-0

Cited by 17 publications

(11 citation statements)

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“… Mean25OHD (nmol/L) a Reference values of vitamin D status Kanani et al 2013 [ 13 ] Karachi, Pakistan Female medical students of Public hospital. 84 15 ± 10.71 25OHD < 25 nmol/L in 96.4% < 75 nmol/L in 98.8% Dar et al 2012 [ 14 ] Karachi, Pakistan Pre-menopausal volunteers 174 38.3 ± 15.23 25OHD < 75 nmol/L in 98.9% Sharif et al 2013 [ 15 ] Lahore, Pakistan Pregnant Lactating women 40 40 26.5 ± 17.1 21.4 ± 16.3 25OHD < 50 nmol/L in 95% 25OHD < 50 nmol/L in 97.5% Aslam et al 2012 [ 16 ] Faisalabad, Pakistan Pregnant women 61 NA 25OHD < 75 nmol/L in 97% Junaid et al 2015 [ 24 ] Lahore, Pakistan Child bearing age working women 215 40.4 ± 34.45 25OHD < 50 nmol/L in 73% 25OHD < 75 nmol/L in 90% Kaykhaei et al 2011 [ 25 ] Zahedan, Iran Adult males 431 Adult females 562 993 34.3 ± 29.43 25OHD < 75 nmol/L in 94.7% Sharma et al 2016 [ 26 ] Delhi, India Pregnant women 418 38.5 ± 22.39 25OHD < 80 nmol/L in 93.5% Salameh et al 2016 [ 27 ] Doha, Qatar Exclusively breast-feeding mothers 60 NA 25OHD < 50 nmol/L in 78% Ullah et al 2013 [ 28 ] Dhaka, Bangladesh Pregnant women 188 61.2 ± 1.78 25OHD < 75 nmol/L in 78% Haugen et al 2016 [ 29 ] Kathmando, Nepal Nursing mothers 500 …”

Section: Discussionmentioning

confidence: 99%

“…In Pakistan the 25OHD levels have been found to be very low in various women populations e.g. 98.8% in female medical students of public sector hospital [ 13 ], 98.9% in premenopausal volunteers [ 14 ] and over 97% in pregnant women [ 15 , 16 ]. The nursing mothers have been out of focus as a specific study group and there are no reports of 25OHD status in women of southern Punjab.…”

Section: Introductionmentioning

confidence: 99%

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Low vitamin D status in nursing Pakistani mothers in an environment of ample sunshine: a cross-sectional study

Mustafa

Asadi

Iqbal³

2018

BMC Pregnancy Childbirth

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BackgroundThe maternal 25-hydroxy vitamin D (25OHD) insufficiency is related to adverse maternal and neonatal outcome. The 25OHD content of breast milk is dependent on 25OHD status of the mothers. We undertook this study to ascertain the 25OHD status and its determinants in the nursing mothers of the south Punjab, Pakistan.MethodsWe recruited 67 mothers for this cross-sectional study by convenience sampling from August 2010 to June 2011 to ascertain their serum 25OHD level & its determinants. We used SPSS 23.0 for analyses.ResultsThe mean age of the mothers was 25.75 ± 4.4 years. The median age (and mode) was 25 years (range 18-37 years). The majority of mothers were less than 25 years of age (62.7%), uneducated (68.7%), from rural area (70.1%), lived in open houses with ample sun exposure (85.1%) and belonged to low socioeconomic strata (71.6%).Serum 25OHD ranged from 7.2 to 43.8 nmol/L with a mean of 20.87 ± 7.69 nmol/L. The median and mode were 21.8 nmol/L & 24.0 nmol/L, respectively. The proportion of mothers with 25OHD < 20 nmol/L (severe deficiency) was 44.8%, < 30 nmol/L (deficiency) 49.3% and < 50 nmol/L (insufficiency) 5.9%. All had 25OHD below 50 nmol/L. The oral supplementation with vitamin D (vD) was the only significant determinant of vitamin D sufficiency.ConclusionsThe majority of Pakistani mothers in south Punjab are vD deficient & universal vD supplementation is the need of the hour to improve health outcomes in mothers & infants.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low vitamin D status in nursing Pakistani mothers in an environment of ample sunshine: a cross-sectional study

Mustafa

Asadi

Iqbal³

2018

BMC Pregnancy Childbirth

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“…Most of the studies did not mention demographic areas (urban/rural) for study population, 4 studies were conducted among urban populations and two studies included both rural and urban populations. Socio economic status for study participants was not mentioned in most of the studies, 8 studies were conducted on both lower and upper socio-economic groups of population and only one study was conducted on lower class population [71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88]. The weighted mean level of vitamin D for study participants was 17.93ng/mL (weighted SD 8.24 ng/mL) [Mean vitamin D level ranged from 8.44 ng/mL to 32ng/mL] and random effect meta-analysis showed that the weighted pooled prevalence of vitamin D de ciency was 73% [95% CI: 63% to 83%] with high degree of heterogeneity (I 2 = 98.20%; p =0.00).…”

Section: Indiamentioning

confidence: 99%

High prevalence of vitamin D deficiency among the South Asian adults: A systematic review and meta-analysis

Siddiqee

Bhattacharjee

Siddiqi

et al. 2021

Preprint

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Background: Vitamin D deficiency is linked to a wide range of chronic and infectious diseases. Body of literature suggested that the prevalence of this deficiency can have geographical variation. Although, vitamin D deficiency is frequently reported in the South Asian population, the scarcity of systematic reviews and meta-analyses means the true extent of the disease and the underlying factors causing it are poorly characterized.Methods: A systematic search was performed using databases (PubMed, Scopus and Google Scholar) for original studies on the South Asian population (published from January 1, 2001 to December 31, 2019). Following the search, a random effect meta-analyses was performed to calculate population level weighted average, pooled prevalence of deficiency, and heterogeneity of vitamin D among different countries and genders; in addition to South Asia as a whole.Results: Our study, based on our selection criteria was narrowed down to a total of 44,717 participants; that spanned over 65 studies from five South Asian countries. Overall, the pooled prevalence of deficiency was 68% [95% CI: 64% to 72%] with significant heterogeneity (I2 = 98%; p = 0.00). Average level of vitamin D ranged from 4.7 to 32 ng/mL, with a weighted mean of 19.15 ng/mL (weighted standard deviation 11.59 ng/mL). The highest prevalence of vitamin D deficiency was found in Pakistan (73%; 95% CI: 63% to 83%) followed by Bangladesh (67%; 95% CI: 50% to 83%), India (67%; 95% CI: 61% to 73%), Nepal (57%; 95% CI: 53% to 60%) and Sri Lanka (48%; 95% CI: 41% to 55%), respectively. This finding indicated a high degree of heterogeneity among the population. (I2 = 98.76%), Furthermore, a gender wise analysis suggested that in South Asia, the prevalence of vitamin D deficiency was higher in females than males. Conclusion: Our findings reveal highly prevalent and variable vitamin D deficiency among the adults of different South Asian countries. Findings from this review would be helpful to generate hypotheses and explore the factors affecting the inter-country variability, alongside strengthening evidence for governments to prioritize mitigation strategies in this region.

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“…According to WHO criteria, individuals with BMD T-scores < -2.5 are osteoporotic and the ones between < -2.5 and -1 are at a high risk of developing osteoporosis, while T-scores > -1 are considered to be normal [2]. Our study depicts increased bone resorption in osteopenic subjects as suggested by the low BMD and high CTx levels [22]. CTx being an authentic bone resorption marker suggests that the bone is having osteoclastic activity going on for the release of minerals like calcium in the blood [23].…”

Section: Discussionmentioning

confidence: 68%

Untitled

2016

ORP

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Background Over 90% of the Pakistani population being vitamin D deficient contributes tremendously to annually increasing trend of osteoporosis worldwide. Fetuin-A is one of the bone turnover markers which play a dynamic role in improving bone health. Similarly, serum beta Crosslaps (CTx) is a sensitive marker of bone resorption. This study aimed to correlate serum levels of fetuin-A and CTx with bone health in healthy females.

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Bone health status of premenopausal healthy adult females in Pakistani females

Abstract: Bone turnover is high with high prevalence of vitamin D deficiency in apparently healthy premenopausal females predisposing them to higher risk for development of osteoporosis.

Cited by 17 publications

References 33 publications

Low vitamin D status in nursing Pakistani mothers in an environment of ample sunshine: a cross-sectional study

Low vitamin D status in nursing Pakistani mothers in an environment of ample sunshine: a cross-sectional study

High prevalence of vitamin D deficiency among the South Asian adults: A systematic review and meta-analysis

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