Bone impairment in oxalosis: An ultrastructural bone analysis

Bacchetta, Justine; Farlay, Delphine; Abelin-Genevois, Kariman; Lebourg, L; Cochat, Pierre; Boivin, Georges

doi:10.1016/j.bone.2015.07.010

Cited by 24 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the presence of vacancies increases solubility of bone mineral. The factors that affect the carbonate‐to‐phosphate ratio are unclear, but it has been suggested that disturbance in the acid‐base equilibrium in bone marrow can modulate the carbonate‐to‐phosphate ratio in renal disease when this equilibrium is impaired or in patients with metastatic prostate cancer …”

Section: Resultsmentioning

confidence: 99%

Variables Reflecting the Mineralization of Bone Tissue From Fracturing Versus Nonfracturing Postmenopausal Nonosteoporotic Women

et al. 2018

Self Cite

View full text Add to dashboard Cite

Women with equivalent areal bone mineral densities may show a different fracture incidence due to differences in bone intrinsic quality. Previously, Fourier transform infrared spectroscopic imaging (FTIRI) on the same iliac bone biopsies reported here, showed that the only significantly different variable was the carbonate/phosphate ratio, which was decreased in the fracturing group. Nanoindentation showed that fracturing bone was less mechanically heterogeneous than nonfracturing bone and could propagate damage (microcracks) more easily. The hypothesis is that fracturing women have reduced mineralization of bone tissue compared to nonfracturing women. Transiliac bone biopsies were collected from fracturing (n = 60, 62.5 ± 7.4 years old) and nonfracturing (n = 60, 62.3 ± 7.3 years old) postmenopausal women, to assess the mineralization of bone tissue using digitized microradiography. The degree of mineralization of bone (DMB, g/cm3) and the heterogeneity index (HI, g/cm3) of the DMB were calculated for cancellous (canc), cortical (cort) and total bone. Results were compared to variables from nanoindentation, FTIRI, and histomorphometry. DMB and HI were not significantly different between fracturing and nonfracturing groups. In the nonfracturing group, cort and canc HI were weakly negatively associated with cort and canc DMB (r′ = −0.388, p < 0.003; r′ = −0.532, p < 0.0001, respectively). In the fracturing group, DMB and HI were negatively correlated only in canc (r′ = −0.295, p = 0.024). DMB and HI were not associated with nanoindentation variables. Cort and canc DMB were positively associated with mineral‐to‐matrix ratio measured by FTIRI (ratio between mineral and organic matrix representing the relative mineralization of the collagen matrix), and negatively associated with carbonate/phosphate ratio. None of the DMB variables were strongly associated with any of the histomorphometric variables. In conclusion, bone mineralization was not significantly different between fracturing and nonfracturing postmenopausal women, suggesting that bone fragility could be partly due to other variables, such as changes in hydration of bone matrix or an increase of non‐enzymatic crosslinks in bone collagen. © 2018 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

show abstract

Section: Resultsmentioning

confidence: 99%

Variables Reflecting the Mineralization of Bone Tissue From Fracturing Versus Nonfracturing Postmenopausal Nonosteoporotic Women

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…More than half of them presented pathological fractures, even months after LT. This is explained by the fact that both oxalate deposits and oxalate release from the bone compartment weaken the skeleton (11). We advise to thoroughly search patients for fractures and to handle the IPH1 patient with care during mobilization, both before and after LT. A good renal osteodystrophy prevention is mandatory in these patients.…”

Section: Discussionmentioning

confidence: 99%

“…In these infants, the renal clearance is exceeded by the liver production resulting in systemic oxalate accumulation (6). Oxalate depositions concern multiple organs such as the heart (7), retina (8), nervous system (9), skin (10), and bones (11,12). The bone overload of oxalate can lead to spontaneous bone fractures but also to joint (13) and medullary (14) damages.…”

Section: Introductionmentioning

confidence: 99%

The Struggling Odyssey of Infantile Primary Hyperoxaluria

et al. 2021

View full text Add to dashboard Cite

Introduction: Oxalate overproduction in Primary Hyperoxaluria type I (PH1) leads to progressive renal failure and systemic oxalate deposition. In severe infantile forms of PH1 (IPH1), end-stage renal disease (ESRD) occurs in the first years of life. Usually, the management of these infantile forms is challenging and consists in an intensive dialysis regimen followed by a liver-kidney transplantation (combined or sequential).Methods: Medical records of all infants with IPH1 reaching ESRD within the first year of life, diagnosed and followed between 2005 and 2018 in two pediatric nephrology departments in Brussels and Paris, have been reviewed.Results: Seven patients were included. They reached ESRD at a median age of 3.5 (2–7) months. Dialysis was started at a median age of 4 (2–10 months). Peritoneal dialysis (PD) was the initial treatment for 6 patients and hemodialysis (HD) for one patient. Liver transplantation (LT) was performed in all patients and kidney transplantation (KT) in six of them. A sequential strategy has been chosen in 5 patients, a combined in one. The kidney transplanted as part of the combined strategy was lost. Median age at LT and KT was 25 (10–41) months and 32.5 (26–75) months, respectively. No death occurred in the series. At the end of a median follow-up of 3 years, mean eGFR was 64 ± 29 ml/min/1.73 m2. All patients presented retinal and bone lesions and five patients presented bones fractures.Conclusion: Despite encouraging survival figures, the morbidity in IPH1 patients remains extremely heavy and its management presents a huge challenge. Thanks to the newly developed RNA-interference drug, the future holds brighter prospects.

show abstract

“…However, excessive vitamin C intake has been associated with oxalose, a disease characterized by calcium oxalate deposition in tissues. Calcium oxalate is a highly insoluble salt, corresponding to an end product of carbohydrate metabolism, vitamin C and some amino acids [35]. Oxalose is divided into two types and secondary may occur due to increased oxalate intake (ascorbic acid/ vitamin C, ethylene glycol, methoxyflurane and oxalaterich foods such as rhubarb, spinach, beet, chocolate and black tea), increased oxalate metabolism and reduced oxalate excretion.…”

Section: Discussionmentioning

confidence: 99%

Bioactive and functional compounds of mixed beverages based on fruits and vegetables

et al. 2020

View full text Add to dashboard Cite

In recent years, the demand for fruits and vegetables has increased in several countries. Thereby, the consumption of natural beverages increased, and specifically those with claims of functional properties. However, there is a clear need for further studies on the beneficial effects of these beverages, and greater attention should be given to brands that use this information in a manner that is unconcerned with consumer health. This work aimed to study the physical-chemical composition and bioactive and functional compounds of some brands of natural drinks marketed in Brazil. Six brands of natural drinks were acquired and analyzed for pH, titratable acidity (%), soluble solids, total sugars, color, total phenolics, vitamin C, β-carotene/linoleic acid, DPPH and dietary fiber. The drinks analyzed are in accordance with the literature for acidity, except the 'E' brand. The sugar content found in three brands ('A, ' 'B-Le' and 'D') was higher than reported on the labels, and the 'A' brand misleads the consumer by stating that their drink is 'zero sugar. ' In general, the drinks showed yellowish color, except the 'E' brand with greenish coloration. The brand 'A' also had higher levels of vitamin C than established by law. The amount of phenolic compounds was higher in the 'A' and 'F' brands. The antioxidant content was higher in 'A, ' 'C' and 'F. ' The 'D' and 'F' brands were shown as sources of dietary fiber. The content of some brands analyzed is in disagreement with their labels which represents a danger to consumers with some kind of food restriction.

show abstract

Bone impairment in oxalosis: An ultrastructural bone analysis

Cited by 24 publications

References 23 publications

Variables Reflecting the Mineralization of Bone Tissue From Fracturing Versus Nonfracturing Postmenopausal Nonosteoporotic Women

Variables Reflecting the Mineralization of Bone Tissue From Fracturing Versus Nonfracturing Postmenopausal Nonosteoporotic Women

The Struggling Odyssey of Infantile Primary Hyperoxaluria

Bioactive and functional compounds of mixed beverages based on fruits and vegetables

Contact Info

Product

Resources

About