Bone inductive properties of rhBMP-2 loaded porous calcium phosphate cement implants in cranial defects in rabbits

Ruhé, P. Quinten; Kroese-Deutman, Henriette C.; Wolke, Joop G.C.; Spauwen, P.H.M.; Jansen, John A.

doi:10.1016/j.biomaterials.2003.09.007

Cited by 153 publications

(116 citation statements)

References 46 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Thus, the amount of targeted cells induced into osteoblasts to enhance bone formation would be limited. This explanation is supported by the findings of Babensee et al 20 Like some studies, 9,21 our study also demonstrated that the combinatory use of BMP with ICPC resulted in improved bone growth, and showed that the ICPC-bBMP composite had no initial burst release; instead, there was a gradual release of BMP followed by the resorption of ICPC. So the use of ICPC can allow for a homogeneous distribution of BMP not only on the surface but also in the whole bulk of the cement, thus making more prolonged BMP release possible, activating simultaneously new …”

Section: Discussionsupporting

confidence: 89%

Comparative in vivo study of injectable biomaterials combined with BMP for enhancing tendon graft osteointegration for anterior cruciate ligament reconstruction

Pan

Wei

Zhou

et al. 2011

Journal Orthopaedic Research

View full text Add to dashboard Cite

This study was to compare effect of osteointegration of grafted tendon in bone tunnels between injected calcium phosphate cement (ICPC) and injected fibrin sealant (IFS) combined with bone morphogenetic protein (BMP) after anterior cruciate ligament (ACL) reconstruction. ACL reconstruction was performed bilaterally in 51 rabbits. ICPC-BMP composite was injected into one knee, with the contralateral knee IFS-BMP composite. The rabbits were killed at postoperative weeks 2, 6, and 12 for testing. Histological observations showed the ICPC composite gradually increased the new bone formation during the whole healing process, while the IFS composite had a burst effect on enhancing the healing of tendon-to-bone at 2 and 6 weeks. By 12 weeks, there was more new cartilage and new bone in the interface in the ICPC-bBMP group. Micro-CT showed that the values of BMD in the ICPC-bBMP group were lower than those in the IFSbBMP group at 6 weeks, while the values in the ICPC-bBMP group were higher than those in the IFS-bBMP group at 12 weeks (p > 0.05). Fluorescent labels showed that the rate of new bone formation of IFS-BMP composite was significantly higher than that of ICPC composite at 6 weeks (3.45 AE 0.62 mm/day vs. 2.93 AE 0.51 mm/day), but the rate was decreased compared with ICPC composite at 12 weeks (2.58 AE 0.72 mm/day vs. 3.05 AE 0.68 mm/day; p < 0.05). Biomechanically, the ultimate failure load in the ICPC-BMP group was always higher than that in the IFS-BMP group. It is evident that the ICPC composite achieved a more prolonged osteogenic effect than that by IFS composite. ß

show abstract

Section: Discussionsupporting

confidence: 89%

Comparative in vivo study of injectable biomaterials combined with BMP for enhancing tendon graft osteointegration for anterior cruciate ligament reconstruction

Pan

Wei

Zhou

et al. 2011

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…The CaP cement used in the production of the porous granules of this study was previously shown to yield a fast deposition of new bone at the cement surface in its paste form [70].…”

Section: Resultsmentioning

confidence: 98%

Preparation of porous apatite granules from calcium phosphate cement

Taş

2007

J Mater Sci: Mater Med

View full text Add to dashboard Cite

A versatile method for preparing spherical, micro-and macroporous (micro: 2-10 and macro: 150-550 lm pores), carbonated apatitic calcium phosphate (Ap-CaP) granules (2-4 mm in size) was developed by using NaCl crystals as the porogen. The entire granule production was performed between 21 and 37°C. A CaP cement powder, comprising a-Ca 3 (PO 4 ) 2 (61 wt.%), CaH-PO 4 (26%), CaCO 3 (10%) and precipitated hydroxyapatite, Ca 10 (PO 4 ) 6 (OH) 2 (3%), was dry mixed with NaCl crystals varying in size from 420 lm to 1 mm. Cement powder (35 wt.%) and NaCl (65 wt.%) mixture was kneaded with an ethanol-Na 2 HPO 4 initiator solution, and the formed dough was immediately agitated on an automatic sieve shaker for a few minutes to produce the spherical granules. Embedded NaCl crystals were then leached out of the granules by soaking them in deionized water. CaP granules were micro-and macroporous with a total porosity of 50% or more. Granules were composed of carbonated, poorly crystallized, apatitic CaP phase. These were the first spherical and porous CaP granules ever produced from a self-setting calcium phosphate cement. The granules reached their final handling strength at the ambient temperature through the cement setting reaction, without having a need for sintering.

show abstract

“…27 The operative procedures and animal care were performed according to the Principles of Shanghai 9th People's Hospital on Animal Experimentation. Ethical approval for undertaking the animal experiment was obtained from the institutional ethics board of the Shanghai Ninth People's Hospital.…”

Section: Animal Modelmentioning

confidence: 99%

Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo

Tang

et al. 2016

IJN

View full text Add to dashboard Cite

Bone inductive properties of rhBMP-2 loaded porous calcium phosphate cement implants in cranial defects in rabbits

Cited by 153 publications

References 46 publications

Comparative in vivo study of injectable biomaterials combined with BMP for enhancing tendon graft osteointegration for anterior cruciate ligament reconstruction

Comparative in vivo study of injectable biomaterials combined with BMP for enhancing tendon graft osteointegration for anterior cruciate ligament reconstruction

Preparation of porous apatite granules from calcium phosphate cement

Osseointegration of nanohydroxyapatite- or nano-calcium silicate-incorporated polyetheretherketone bioactive composites in vivo

Contact Info

Product

Resources

About