Bone infection in cat-scratch disease: A review of the literature

Hajjaji, Nawale; Hocqueloux, Laurent; Kerdraon, R.; Bret, Laurent

doi:10.1016/j.jinf.2006.10.045

Cited by 78 publications

(106 citation statements)

References 54 publications

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“…The thoracic, lumbar, and cervical vertebrae are usually affected. 5 Involvement of the ribs, cranium, and long bones has also been described. 6,7 Bone scintigraphy, indicated by pain (spontaneous or triggered by palpation), can identify such lesions, even in subclinical cases.…”

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confidence: 99%

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Cat-Scratch Disease and Bone Scintigraphy

Ismaili-Alaoui

Vuong²,

Marcu-Marin³

et al. 2012

Clinical Nuclear Medicine

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Cat-scratch disease is a bacterial infection caused by Bartonella henselae. Bone involvement is rare. We describe the case of a 7-year-old boy with a systemic form of the disease. He presented with a 15-day history of fever, altered general condition, weight loss and cough, associated with back pain, and right-sided coxalgia. Bone scintigraphy with Tc-99m hydroxymethylene diphosphonate showed spinal involvement, the iliac crest, the right ankle, and the right first metatarsal. Magnetic resonance imaging confirmed these locations. He was positive for anti-Bartonella henselae. The fever regressed before treatment with rifampicin began, and he made a full recovery.

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confidence: 99%

“…8,9 Moreover, MRI can simultaneously detect complications such as epidural abscess or spinal compression 10 that may necessitate surgery. 4,5 Bone involvement associated with cat-scratch disease is a rare diagnosis in pediatric bone scintigraphy, but nuclear physicians should be aware of this etiology. The vertebral bodies or posterior arches may be affected.…”

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confidence: 99%

Cat-Scratch Disease and Bone Scintigraphy

Ismaili-Alaoui

Vuong²,

Marcu-Marin³

et al. 2012

Clinical Nuclear Medicine

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“…In 2007, Hajjaji et al (2007) reported 36 pediatric cases, and since then, an additional 13 cases of osteomyelitis due to B. henselae have been described, including ours. One case of Bartonella osteomyelitis of the acetabulum was reported by Krause et al in 2000 in a 29-year-old adult male (Krause et al 2000).…”

Section: Discussionmentioning

confidence: 67%

BartonellaOsteomyelitis of the Acetabulum: Case Report and Review of the Literature

Puri

Kreppel

Schlaudecker

2015

Vector-Borne and Zoonotic Diseases

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Introduction: Bartonella henselae commonly involves the mononuclear phagocyte system (MPS), and its most common presentation is lymphadenitis. Rarely, it can cause isolated osteomyelitis. We present a case of a 3 year old with constitutional symptoms and new onset of limp. Previously reported cases of osteomyelitis due to B. henselae are also reviewed here, keeping the index case in mind. Methods: We conducted a Medline search using MeSH subject headings Bartonella and osteomyelitis, limited to humans. Results: The index case is a 3-year-old female who had a subacute presentation with new-onset leg pain and fever. Subsequent imaging demonstrated osteomyelitis of the acetabulum. Multiple diagnostic attempts were unsuccessful, and the patient did not respond to empiric therapy. Despite indeterminate serology, the diagnosis of Bartonella osteomyelitis was eventually confirmed by PCR on bone biopsy of the lesion. The literature search revealed 48 publications, which were reduced to 28 when limiting articles to the English language and the pediatric population. After a report of 36 pediatric cases in 2007, there have been an additional 12 pediatric cases since 1998. Generally, these patients had a subacute presentation with relatively mild constitutional symptoms. Most commonly, bone involvement occurred as osteolytic lesions of the axial skeleton. Of the total 48 cases reported, only four reported involvement of the axial skeleton. Conclusion: We present the first case, to our knowledge, of pediatric osteomyelitis of the pelvis due to B. henselae with indeterminate serologic and positive PCR results. Bartonella osteomyelitis should be included in the differential diagnosis when typical pathogens are not identified or if the patient is slow to respond to standard therapies. The sensitivity of tissue PCR for Bartonella osteomyelitis is now better than the current gold standard of serology, and new management guidelines may need to reflect this.

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“…The most frequent bones involved are vertebrae, pelvis and ribs. Patients present with localized pain possibly along with inflammatory signs in the adjacent soft tissues, although some bone lesions are asymptomatic and are only detected by scintigraphy and/or radiology (4,5). Magnetic resonance imaging (MRI) allows early detection prior to tomodensitometry or X-ray (5).…”

Section: Discussionmentioning

confidence: 99%

Atypical Cat-Scratch Disease in Children: Report of Seven Presentations Ranging From Hepatosplenic Disease to Horner Syndrome

Gilliaux

Ghilain

Linden

et al. 2016

Arch Pediatr Infect Dis

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Introduction: Cat scratch disease (CSD) is an infectious disease caused by the Gram-negative rod Bartonella henselae (BH). It usually leads to subacute loco-regional lymphadenitis occasionally associated with fever. In most of the cases, it resolves spontaneously within 4 -6 weeks. However, CSD has also been associated with other atypical presentations. Case Presentation: We reported a series of seven children with unusual symptoms of CSD. In particular, we described the case of a child with ptosis, miosis and enophtalmy, suggesting Horner syndrome, associated with cervical lymphadenitis. Cat scratch was mentioned in only one patient, while four of them mentioned a recent contact with cats. We reviewed and discussed the incidence of these atypical presentations of CSD as well as the therapeutic approaches recommended and the available diagnostic tools. Conclusions: This paper highlighted the need to exclude CSD in children with unexplained symptoms such as prolonged fever, hepatosplenic lesion and osteomyelitis.

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Bone infection in cat-scratch disease: A review of the literature

Cited by 78 publications

References 54 publications

Cat-Scratch Disease and Bone Scintigraphy

Cat-Scratch Disease and Bone Scintigraphy

BartonellaOsteomyelitis of the Acetabulum: Case Report and Review of the Literature

Atypical Cat-Scratch Disease in Children: Report of Seven Presentations Ranging From Hepatosplenic Disease to Horner Syndrome

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