2023
DOI: 10.3390/biology12101320
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Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review

Francesco Orsini,
Chiara Crotti,
Gilberto Cincinelli
et al.

Abstract: Several rheumatologic diseases are primarily distinguished by their involvement of bone tissue, which not only serves as a mere target of the condition but often plays a pivotal role in its pathogenesis. This scenario is particularly prominent in chronic inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis (SpA). Given the immunological and systemic nature of these diseases, in this review, we report an overview of the pathogenic mechanisms underlying specific bone involvement, focusi… Show more

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Cited by 4 publications
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“…However, the expression and functional response to IL-17A appears to be similar in the synovitis of psoriatic arthritis and rheumatoid arthritis [47]. Dkk-1 is abundantly expressed in inflamed joints of destructive and remodelling forms of arthritis, playing an important role in the pathogenesis of RA and PsA [48,49].…”
Section: Discussionmentioning
confidence: 99%
“…However, the expression and functional response to IL-17A appears to be similar in the synovitis of psoriatic arthritis and rheumatoid arthritis [47]. Dkk-1 is abundantly expressed in inflamed joints of destructive and remodelling forms of arthritis, playing an important role in the pathogenesis of RA and PsA [48,49].…”
Section: Discussionmentioning
confidence: 99%