Bone Involvement in Systemic Lupus Erythematosus

Rella, Valeria; Rotondo, Cinzia; Altomare, Alberto; Cantatore, Francesco Paolo; Corrado, Addolorata

doi:10.3390/ijms23105804

Cited by 11 publications

(13 citation statements)

References 73 publications

(255 reference statements)

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“…Joint structural damage is one of the most important causes of disability in SLE patients, 20 therefore, its prediction, early detection and treatment are considered a priority.…”

Section: Discussionmentioning

confidence: 99%

“…1 These patients had previously been diagnosed with SLE (according to the 1982/ 1987 American College of Rheumatology criteria) 16,17 in six different centers in the city of Madrid and were under follow-up in rheumatology, internal medicine, dermatology and nephrology units. As this was a study to detect subclinical synovitis, the clinical joint profile of patients was: completely asymptomatic (20), with sporadic arthralgias without arthritis (34) and with sporadic arthritis without joint damage (42).…”

Section: Patientsmentioning

confidence: 99%

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Subclinical synovitis impact on the progression of lupus joint disease: A 10-year longitudinal multicenter study

Guillén-Astete,

Revenga-Martínez,

Zea-Mendoza

et al. 2024

Lupus

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Objective To determine the effect of subclinical synovitis on the progression of joint disease in a cohort of patients with systemic lupus erythematosus over a mean follow-up of 10 years. Methods A longitudinal follow-up of 96 patients diagnosed with lupus was performed. All patients were considered clinically free of joint disease or with minimal joint impairment at baseline and were studied through ultrasound study of their dominant hand to assess the prevalence of subclinical synovitis. Now, over 10 years after we contacted them and reviewed their evolution to determine the impact of had or had not been diagnosed with subclinical synovitis in their current joint condition. Results Thirty-one of the 91 reached patients developed clinical progression in their joint manifestations (at least one ordinal degree of worsening). Of these, 23 (74,9%) had demonstrated subclinical synovitis at baseline. In the group of patients who did not progress clinically, 46 (76,6%) did not have this finding at the start of follow-up ( p < .01, OR 9,44 95%CI 3,46–25,74). The patients in whom clinical progression was demonstrated had worse combined ultrasound scores than the rest of the patients: 6,41 SD 1,45 vs. 1,15 SD 0,97 ( p < .01). Conclusions The finding of subclinical synovitis in patients with systemic lupus erythematosus is associated with the development of joint disease progression both clinically and ultrasonographically.

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“…Joint structural damage is one of the most important causes of disability in SLE patients, 20 therefore, its prediction, early detection and treatment are considered a priority.…”

Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Subclinical synovitis impact on the progression of lupus joint disease: A 10-year longitudinal multicenter study

Guillén-Astete,

Revenga-Martínez,

Zea-Mendoza

et al. 2024

Lupus

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“…Причиной периферического болевого синдрома, нередко ошибочно трактуемого как проявление артрита, могут быть инфаркты костного мозга (ИКМ) [46]. Частота их неизвестна, так как в основном они диагностируются, когда развивается аваскулярный некроз (АВН).…”

unclassified

“…Частота их неизвестна, так как в основном они диагностируются, когда развивается аваскулярный некроз (АВН). ИКМ ассоциированы с высокой активностью заболевания, васкулитом, молодым возрастом, высокой дозой ГК [46]. G.Q.…”

unclassified

“…В настоящее время АВН -хорошо известная причина связанного с СКВ стойкого повреждения, распространенность которого, по разным данным, составляет 5-23% при юСКВ и достигает 40% при проведении МРТ бессимптомным пациентам [50,54,55]. Наличие множественных ИКМ, а также поверхностное их расположение повышают вероятность формирования АВН [46]. Y. Yang и соавт [56] обнаружили манифестные АВН у 6% пациентов с юСКВ при средней продолжительности заболевания 2,3 года.…”

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Musculoskeletal symptoms in juvenile onset systemic lupus erythematosus

Kaleda,

Arefieva,

Nikishina

2023

Sovremennaâ revmatologiâ

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In juvenile onset systemic lupus erythematosus (SLE), musculoskeletal involvement is one of the most common manifestations. Musculoskeletal symptoms may be due to disease activity itself, organ damage due to SLE activity, drug exposure, or comorbidities. Although they are not life-threatening, they still have a significant impact on disability severity and social exclusion. This article discusses the clinical features of various causes of musculoskeletal manifestations in SLE with onset in childhood and adolescence, the adequate interpretation of which is important for diagnosing and evaluating SLE activity and for correcting the treatment of the disease, thereby improving the long-term prognosis and quality of life of patients.

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Shared molecular signatures between systemic lupus erythematosus and osteoporosis

Yuan,

Zheng,

Lai

2024

Environmental Toxicology

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This study explores the molecular interplay between systemic lupus erythematosus (SLE) and osteoporosis (OP), aiming to uncover shared gene signatures and pathways for better treatment approaches. Leveraging microarray data from the Gene Expression Omnibus (GEO) database, we employed weighted gene coexpression network analysis to identify coexpression modules in SLE and OP, with subsequent protein–protein interaction analysis clarifying the connections among shared genes. Key genes were pinpointed using CytoHubba and random forest algorithms, validated across independent GEO datasets, and further analyzed through gene set enrichment analysis (GSEA) and immune infiltration studies. We discovered two highly correlated modules in SLE and OP, isolating 30 shared genes and identifying GBP1, SOCS1, IFI16, and XAF1 as central to both conditions. Notably, XAF1 and GBP1 mRNA levels were significantly elevated in the peripheral blood of SLE patients compared with healthy and RA counterparts, underscoring their potential as biomarkers. GSEA and immune infiltration analyses indicated pronounced immune and inflammatory responses, especially in interferon signaling pathways, implicating these core‐shared gene networks in the diseases' pathogenesis. The findings highlight the involvement of GBP1, SOCS1, IFI16, and XAF1 in SLE with concurrent OP and suggest that targeting immune and inflammatory responses, particularly through interferon pathways, may offer therapeutic promise for these intertwined conditions.

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Bone Involvement in Systemic Lupus Erythematosus

Cited by 11 publications

References 73 publications

Subclinical synovitis impact on the progression of lupus joint disease: A 10-year longitudinal multicenter study

Subclinical synovitis impact on the progression of lupus joint disease: A 10-year longitudinal multicenter study

Musculoskeletal symptoms in juvenile onset systemic lupus erythematosus

Shared molecular signatures between systemic lupus erythematosus and osteoporosis

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