Bone loss biomarkers associated with peri‐implantitis. A cross‐sectional study

Rakić, Mia; Lekovic, Vojislav; Nikolić-Jakoba, Nataša; Vojvodić, Danilo; Petković-Ćurčin, Aleksandra; Sanz, Mariano

doi:10.1111/j.1600-0501.2012.02518.x

Cited by 72 publications

(89 citation statements)

References 48 publications

(101 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar to findings in GCF obtained from sites with periodontitis (Belibasakis and Bostanci 2012), there is increasing evidence showing the association of the receptor activator of nuclear factor kappaB ligand (RANKL) -osteoprotegerin (OPG) system with the occurrence and severity of periimplantitis (Arikan et al 2008;Arikan et al 2011;Sarlati et al 2010;Guncu et al 2012;Duarte et al 2009a;Duarte et al 2009b;Rakic et al 2013). A few studies looking into other markers of bone metabolism, such as osteocalcin, reported that these are higher in PICF from peri-implant mucositis compared to healthy sites, whereas no differences were observed between periimplatitis and either mucositis or health.…”

mentioning

confidence: 73%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

108

View full text Add to dashboard Cite

Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.

show abstract

mentioning

confidence: 73%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

108

View full text Add to dashboard Cite

show abstract

“…Arikan et al [55] reported that sRANKL concentrations, OPG total amounts, and OPG concentrations were significantly lower in peri-implantitis group when compared to healthy group. In contrast, RANKL, RANK, and OPG concentrations were found to be significantly higher in peri-implantitis sites compared with healthy implant sites, but the ratio of OPG/RANKL was not different [56]. It was also demonstrated that the OPG/RANKL ratio improved with mechanical treatment of peri-implantitis sites [26].…”

Section: Discussionmentioning

confidence: 99%

Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

Dursun

Tözüm

2016

JOMR

View full text Add to dashboard Cite

ObjectivesTo review the current understanding of the biomarkers and enzymes associated with different forms peri-implant diseases and how their level changes influence the pathogenesis of the inflammatory diseases around dental implants.Material and MethodsAn electronic search in two different databases was performed including MEDLINE (PubMed) and EMBASE between 1996 to 2016. Human studies analyse peri-implant crevicular fluid (PICF) biomarker and enzyme levels of implants having peri-implant mucositis and peri-implantitis published in English language, were evaluated. A systematic review was performed to assess which biomarkers and enzymes in PICF were used to identify the inflammatory conditions around dental implants.ResultsFifty-one articles were identified of which 41 were further evaluated and included in the analysis. Due to significant heterogeneity between included studies, a meta-analysis could not be performed. Instead, a systematic descriptive review was performed.ConclusionsBiomarkers and enzymes in peri-implant crevicular fluid have shown promising results in differentiating from peri-implant disease condition to health. However, due to inconsistent results and acquiring much evidence from cross-sectional studies, additional evidence supported by randomized-controlled trials is needed to validate the links reported.

show abstract

“…Thus direct, indirect and synergic RANKL induced osteoclastogenesis play a role. Regarding the PICF levels, results are not consistent, and increased [63,64], lower [65] and similar [58,66] RANKL levels have been reported when comparing untreated diseased implants with healthy implants. However, the interpretation of these results cannot be dissociated from the overall RANKL/RANK/OPG system and the RANKL/OPG ratio, as the biological activity of RANKL is regulated by its decoy receptor OPG.…”

Section: Bone Cells Activity During Peri-implantitismentioning

confidence: 94%

Bone Cells Dynamics during Peri-Implantitis: a Theoretical Analysis

Fernandes¹,

Gomes

2016

JOMR

View full text Add to dashboard Cite

ObjectivesThe present manuscript aims a detailed characterization of the bone cells dynamics during physiological bone remodelling and, subsequently, to address the cellular and molecular mechanisms that play a fundamental role in the immune-inflammatory-induced uncoupled bone remodelling observed in peri-implantitis.ResultsAn intimate relationship between the immune system and bone is acknowledged to be determinant for bone tissue remodelling and integrity. Due to the close interaction of immune and bone cells, the two systems share a number of surface receptors, cytokines, signalling pathways and transcription factors that are involved in mutual regulatory mechanisms. This physiological equilibrium is disturbed in pathological conditions, as verified in peri-implantitis establishment and development. Activation of the innate and adaptive immune response, challenged by the local bacterial infection, induces the synthesis of high levels of a variety of pro- and anti-inflammatory cytokines that disturb the normal functioning of the bone cells, by uncoupling bone resorption and formation, ending up with a net alveolar bone loss and subsequent implant failure. Most data points to an immune-inflammatory induced osteoclast differentiation and function, as the major underlying mechanism to the uncoupled bone resorption to bone formation. Further, the disturbed functioning of osteoblasts, reflected by the possible expression of a fibro-osteoblastic phenotype, may also play a role.ConclusionsAlveolar bone loss is a hallmark of peri-implantitis. A great deal of data is still needed on the cellular and humoral crosstalk in the context of an integrated view of the osteoimmunologic interplay occurring in the peri-implantitis environment subjacent to the bone loss outcome.

show abstract

Bone loss biomarkers associated with peri‐implantitis. A cross‐sectional study

Abstract: The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.

Cited by 72 publications

References 48 publications

Peri-Implant Infections of Oral Biofilm Etiology

Peri-Implant Infections of Oral Biofilm Etiology

Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

Bone Cells Dynamics during Peri-Implantitis: a Theoretical Analysis

Contact Info

Product

Resources

About