Bone Marrow B cell Precursor Number after Allogeneic Stem Cell Transplantation and GVHD Development

Fedoriw, Yuri; Samulski, T. Danielle; Deal, Allison M.; Dunphy, Cherie H.; Sharf, Andrew; Shea, Thomas C.; Serody, Jonathan S.; Sarantopoulos, Stefanie

doi:10.1016/j.bbmt.2012.03.005

Cited by 37 publications

(32 citation statements)

References 25 publications

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“…17 In contrast, cGVHD patients who demonstrate clinical improvement and positive response to treatment have robust recovery of the peripheral naive B-cell pool. 13,18,19 These findings are consistent with previous demonstration in murine models that physiologic BAFF/B-cell ratios result in deletion of autoreactive B cells. 20 In contrast, when BAFF is in excess, peripheral tolerance is lost and autoreactive B cells survive.…”

Section: Introductionsupporting

confidence: 91%

B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways

Allen

Fore

Wooten

et al. 2012

Blood

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123

116

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Section: Introductionsupporting

confidence: 91%

B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways

Allen

Fore

Wooten

et al. 2012

Blood

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123

116

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“…This is supported by the fact that all our patients displaying high numbers of BLP were free of chronic GvHD, in contrast to one patient with chronic GvHD who showed very low MLP and BLP counts. 41 As nearly all our patients who underwent allogeneic transplantation during the past 2 years had received BMd but not PBSC, we cannot establish whether the MPP compartment in BM1y would be significantly larger after transplantation of allogeneic PBSC instead of BMd. However, the data presented by Bhatia et al 40 and own preliminary results from two patients who had received allogeneic PBSC comprising MPP numbers clearly higher than those analyzed in BMd suggest that the proportion of early precursors is strongly reduced even after transplantation of allogeneic PBSC.…”

Section: Discussionmentioning

confidence: 95%

Multi-color immune-phenotyping of CD34 subsets reveals unexpected differences between various stem cell sources

Dmytrus

Matthes‐Martin

Pichler

et al. 2016

Bone Marrow Transplant

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Flow cytometric routine CD34 analysis enumerates hematopoietic stem and progenitor cells irrespective of their subpopulations although this might predict engraftment dynamics and immune reconstitution. We established a multi-color CD34 assay containing CD133, CD45RA, CD10, CD38 and CD33. We examined PBSC, donor bone marrow (BMd) and BM of patients 1 year after allografting (BM1y) regarding their CD34 subset composition, which differed significantly amongst those materials: the early CD45RA − CD133 + CD38 low subpopulations were significantly more frequent in PBSC than in BMd, and very low in BM1y. Vice versa, clearly more committed CD34 stages prevailed in BM, particularly in BM1y where the proportion of multi-lymphoid and CD38 ++ B-lymphoid precursors was highest (mean 59%). CD33 was expressed at different intensity on CD45RA ± CD133 ± subsets allowing discrimination of earlier from more committed myeloid precursors. Compared with conventional CD34 + cell enumeration, the presented multicolor phenotyping is a qualitative approach defining different CD34 subtypes in any CD34 source. Its potential impact to predict engraftment kinetics and immune reconstitution has to be evaluated in future studies.

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“…Supranormal numbers of naive and circulating transitional B cells after HSCT are common in patients who do not go on to develop cGVHD. 20,36,37 Increased levels of k-deleting recombination excision circles, rapid naive B-cell recovery, and low BAFF/B-cell ratios after umbilical cord blood transplantation have also been associated with a low incidence of cGVHD. 35 In contrast, delayed B-cell recovery in the early post-HSCT period has been linked to both decreased numbers of precursor B cells and decreased bone marrow production of transitional B cells.…”

Section: Establishing B-cell Tolerance After Allogeneic Hsctmentioning

confidence: 99%

Aberrant B-cell homeostasis in chronic GVHD

Sarantopoulos

Ritz

2015

Blood

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107

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Recent studies have compelled further interest in the potential pathological role of B cells in chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated and primed for survival via B-cell activating factor and B-cell receptor–associated pathways. Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate the development of new strategies to selectively target aberrantly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantation.

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Bone Marrow B cell Precursor Number after Allogeneic Stem Cell Transplantation and GVHD Development

Cited by 37 publications

References 25 publications

B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways

B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways

Multi-color immune-phenotyping of CD34 subsets reveals unexpected differences between various stem cell sources

Aberrant B-cell homeostasis in chronic GVHD

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