Bone marrow bi-hypoplasia in a dog with a sertoli cell tumor

Couto, Rodrigo M.; Gamba, Conrado de Oliveira; Vasconcelos, A.V.; Leme, Fabíola Oliveira Paes; Ecco, Roselene; Paes, Paulo Ricardo de Oliveira

doi:10.1590/1678-4162-8922

Cited by 7 publications

(7 citation statements)

References 10 publications

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“…A apresentação clínica do paciente descrito nesse relato é bastante observada por outros pesquisadores, que afirmam que tumores nas células de sertoli, podem desenvolver hiperestrogenismo secundário a neoplasia, sendo tóxico para a medula óssea, levando a hipoplasia de todas as linhagens hematopoiéticas (SONTAS et al, 2009;HOLST & DREIMANIS, 2015;ARGENTA et al, 2017;VALENTE et al, 2017) Essas complicações hemodinâmicas podem ter sido causadas por anemia aplásica, tendo como causa a mielotoxicidade causada pelo hiperestrogenismo (WEISS, 2003;SONTA et al, 2009;MORAES & TAKAHIRA, 2010;FERREIRA et al, 2018).…”

Section: Discussionunclassified

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Sertolioma em um canino: relato de caso

Pinto de Oliveira Lima,

Da Fontoura Moura,

Moukaddem de Souza

et al. 2023

PRW

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Neoplasias testiculares, como o sertolioma, são frequentes em cães idosos, não castrados e criptorquidas. Esses tumores se originam em células de leidig, sertoli e/ou seminoma, de caráter benigno, e manifestado de forma unilateral. O objetivo do trabalho foi relatar o caso de um canino, macho, 5 anos e criptorquida, descrevendo as alterações causadas pela mielotoxicidade do hiperestrogenismo secundário ao sertolioma. O animal, apresentou aumento volume em região abdominal, mucosas hipocoradas, hiperpigmentação genital, prepúcio pendular, ginecomastia generalizada e a presença de apenas um testículo. Parâmetros vitais sem alterações. No hemograma, anemia grave, leucopenia e trombocitopenia, nos bioquímicos séricos e tempos de coagulação sem alterações. No ultrassom, a presença de uma massa em região abdominal caudal, com testículo esquerdo ectópico e testículo direito diminuído com degeneração. Foi realizado laparotomia exploratória, extraindo o testículo esquerdo ectópico, e orquiectomia do testículo direito. Como tratamento domiciliar, recebeu analgésicos e antibiótico, além de terapia com Lítio. Desta forma, os tratamentos foram sucesso, pois o animal ganhou uma sobrevida com qualidade de vida.

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Section: Discussionunclassified

“…eritroide, mieloide e megacariocítica) induzida por estrógeno. Sendo assim, o Lítio estimula a divisão das células-tronco pluripotentes (SANPERA et al, 2002;MORAES & TAKAHIRA, 2010;VALENTE et al, 2017).…”

Section: Discussionunclassified

Sertolioma em um canino: relato de caso

Pinto de Oliveira Lima,

Da Fontoura Moura,

Moukaddem de Souza

et al. 2023

PRW

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“…16,23 In part, increased estrogen production by neoplastic cells leads to feminine behaviors and gynecomastia, as well as other paraneoplastic effects (alopecia, prostatic squamous metaplasia, and myelosuppression). 19,23,24 Medullary bone formation is 1 component of a proposed paraneoplastic feminization syndrome in male budgerigars, which has previously been reported to include cere color change, widening of the pelvic inlet, and protrusion of the cloaca. 13 The latter 2 were not observed in this study.…”

Section: Discussionmentioning

confidence: 99%

Medullary bone in male budgerigars (Melopsittacus undulatus) with testicular neoplasms

Hoggard

Craig

2022

Vet Pathol

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Medullary bone is a calcium-rich, labile bone normally occurring in female birds with each egg-laying cycle. The stimulus for formation of medullary bone is, in part, the cyclic increase in serum estrogens produced by preovulatory ovarian follicles. Increased bone density due to formation of medullary bone, particularly in pneumatic bones, has been termed polyostotic hyperostosis, even if physiologic. This study investigated the formation of medullary bone in nonpneumatic (femur) and pneumatic (humerus) bones in sexually mature male budgerigars submitted for autopsy. Of the 21 sexually mature male budgerigars submitted for autopsy, 7 (33%) had medullary bone in 1 or more bones examined. All 7 male budgerigars with medullary bone had a testicular neoplasm, which was morphologically consistent with a testicular sustentacular cell tumor, seminoma, or interstitial cell tumor. Medullary bone was not present in the 14 cases with other diseases. Medullary bone formation in pneumatic and nonpneumatic bones can occur in male budgerigars with testicular neoplasms. Radiographic increases in medullary bone density, particularly in the humerus, could provide antemortem indication of testicular neoplasia in male budgerigars.

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“…Para o presente relato, o exame citológico foi de extrema relevância, uma vez que serviu como forma de triagem para a definição da origem neoplásica da massa intra-abdominal. Os achados citopatológicos detectados foram condizentes com as observações de Valente et al [17], que constataram para o sertolioma, uma intensa concentração de células redondas com moderada relação núcleo/citoplasma, associada a anisocitose e anisocariose.…”

Section: Discussionunclassified

Intra-abdominal Sertoli Cell Tumor in Dog with Local and Systemic Repercussions

Ferreira

Feranandes

Silva

et al. 2018

Acta Scientiae. Vet.

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Background: In dogs, abdominal testes have higher risk of malignant transformation, and the Sertoli cell tumor is the most common type of testicular cancer in the species. This neoplasia can lead to an increase on estrogen production, causing a paraneoplastic feminization syndrome with dermatologic, behavioral and blood repercussions. When located inside theabdomen, the Sertoli cell tumor can compress adjacent organs, worsening the prognosis. Thus, this study aimed to report a case of an intra-abdominal Sertoli cell tumor in a dog associated to multiple organic complications.Case: A 4-year-old male Shih-tzu was admitted at the Veterinary Hospital of Universidade Federal Rural do Semi-Árido (UFERSA), with a history of abdominal cryptorchidism and the development of dermatological signs, such as alopecia and hyperpigmentation, with an evolution of two months. At physical examination it was observed alopecia on lumbosacral regionand on hind limbs, hyperpigmentation, gynecomastia and pendulous prepuce, suggestive of feminization syndrome. A firm mass was palpated on caudal abdomen. The following exams were requested: complete blood cell count, serum biochemistry (alanine aminotransferase, alkaline phosphatase, creatinine and urea), abdominal ultrasonography and fine needle aspiration cytology of the abdominal mass. Hematological and biochemistry profile were within the normal range for the species. Onthe ultrasonography, regular and rounded structures were observed, suggesting ectopic testes (left testis: 2.37 x 2.95 cm; right testis: 1.92 x 1.38 cm). The left testis presented characteristics of malignant transformation. The cytology of the abdominal mass suggested Sertoli cell tumor. The dog was submitted to an exploratory laparotomy. The right testis was atrophied and its orchiectomy was performed. The contralateral testis was completed adhered to great vessels, such as abdominal aorta and caudal vena cava, and also to adjacent viscera. Thus, the exeresis of the tumor was not possible and fragments of the mass were collected and referred to histopathology. The left testicle presented tumoral polyedric cells, alonged at the longitudinal axis, propagating disorderly, and with central rounded nucleus, and a clear and vacuolar cytoplasm. It was alsoobserved desmoplasia, anisocytosis, anisocariasis, nuclear atypia and evident nucleoli. The mitotic index was less than one mitotic figure/40x, with aberrant mitotic figures. The histopathological evaluation was compatible with Sertoli cell tumor, confirming the presumptive diagnosis. Chemotherapy was proposed, but the animal’s owner refused. After four months the dog was readmitted presenting a series of complications due to the tumor growth, including bone marrow hypoplasia, gallbladder compression and hydronephrosis. Because of the poor prognosis and severity of complications a decision to euthanize the animal was made.Discussion: Intra-abdominal Sertoli cell tumors have good prognosis when the diagnosis and surgical treatment are made early. Nevertheless, this neoplasia can be associated to critical and irreversible damages to various organs, such as bone marrow hypoplasia, and compression of abdominal organs when the tumor grows rapidly and invades adjacent structures,making the complete surgical exeresis impossible. Therefore, the orchiectomy of cryptorchidic dogs is recommended as soon as possible to prevent the development of testicular cancer in these animals.Keywords: cryptorchidism, testicular neoplasia, Canis lupus familiaris.

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Bone marrow bi-hypoplasia in a dog with a sertoli cell tumor

Cited by 7 publications

References 10 publications

Sertolioma em um canino: relato de caso

Sertolioma em um canino: relato de caso

Medullary bone in male budgerigars (Melopsittacus undulatus) with testicular neoplasms

Intra-abdominal Sertoli Cell Tumor in Dog with Local and Systemic Repercussions

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