Bone marrow biopsy changes following chemotherapy for acute leukemia

A Distinct p53 Protein Isoform Signature Reflects the Onset of Induction Chemotherapy for Acute Myeloid Leukemia

“…1C). During AML induction, therapy apoptosis was not seen in the peripheral circulation up to 18 hours, 7 and previous studies have only been able to detect apoptotic AML cells in bone marrow after 24 to 48 hours (48,49). At the same time, cytopenia developed within 3 to 6 days in our patients (Table 1) with significant decline in peripheral leukemic cells during the first 18 hours.…”

The Significance of Light Chain-Restricted Bone Marrow Plasma Cells After Peripheral Blood Stem Cell Transplantation for Multiple Myeloma

“…Previous studies have shown that plasmacytosis is a common finding in the early posttransplantation bone marrow biopsy specimens of patients who have undergone ablative chemotherapy for acute leukemia. 10,11 Therefore, the presence of plasmacytosis in the bone marrow biopsy specimens of patients who have undergone stem cell transplantation for MM was not unexpected, although the significance of early plasmacytosis in this disease was unknown. Transient, and rarely persistent, monoclonal gammopathies previously have been reported in patients who have undergone bone marrow transplantation for a variety of diseases, including aplastic anemia, acute leukemia, chronic myeloid leukemia, and congenital immunodeficiency states.…”

“…The morphologic features were compared with immunohistochemical stains for K and X light chains and with traditional clinical indicators of disease activity in an attempt to identify pretransplantation features in the biopsy specimens that correlate with outcome and posttransplantation changes in the biopsy specimens that are associated with disease progression. In particular, given the frequency of reactive plasmacytosis in the early posttransplantation marrow specimens of persons who have undergone BMT for diseases other than MM, 10,11 we queried whether plasma cells in early posttransplantation marrow specimens in patients with MM are clonal and whether this information is prognostically significant. University Hospital (Stanford, Calif).…”

Predicting the presence or absence of ringed sideroblasts in patients suspected of having a myelodysplastic syndrome and increased iron stores: a simple observation

“…5 Increased hemosiderin deposits are commonly seen in chronically transfused patients for various reasons including chemotherapy induced anemia. 6 Myelodysplastic syndromes quite frequently have increased bone marrow iron stores. 7 Increased iron deposits in patients with RARS have been described as finely granular or rarely coarsely granular.…”