Bone marrow biopsy in non-Hodgkin lymphoma: A morphological study

Kumar, Suneet; Rau, Aarathi R.; Naik, Ramadas; Kini, Hema; Mathai, Alka Mary; Pai, Muktha R; Khadilkar, Urmila N

doi:10.4103/0377-4929.54987

Cited by 25 publications

(26 citation statements)

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“…Kumar A showed involvement by lymphoma on biopsy in 27 cases (55.10%). 13 Unilateral positivity was found in four cases (14.81% cases). The overall incidence of marrow involvement by NHL was 55.1%.…”

Section: Discussionmentioning

confidence: 99%

Bone marrow profile in hematological disorders: an experience from a tertiary care centre

Bashir

Musharaf

Reshi³

et al. 2018

Int J Adv Med

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Background: Bone marrow aspiration and trephine biopsy are two most important techniques which are complementary for diagnosing both neoplastic and non- neoplastic haematological diseases. The present study was conducted in the department of pathology to compare the role of bone marrow aspirate and trephine biopsy for diagnosing the haematological diseases.Methods: The study was conducted in the department of pathology government medical college Srinagar over a period of 2 years from Feb 2016 to Jan 2018. The study was one-year retrospective and one year prospective. Bone marrow aspiration was done in 626 cases out of which biosy was done in 300 cases.Results: Out of the selected 300 cases were both aspiration and trephine biopsy were available, diagnostic material on bone marrow aspirate was adequate in 288 cases. 12 cases were aparticulate. Biopsy was inadequate in 8 cases. Overall megaloblastic anaemia (26.6%) was most common followed by dual deficiency anemia. Multiple myeloma was the most common neoplastic pathology (13%) followed by followed by acute leukaemia’s (6%) and Chronic lymphoproliferative disorders (CLPDS) (5%). 1 case each of visceral leishmaniasis and malarial parasite were also noted. 4 cases (1.3%) of granulomatous pathology and 2 cases (0.6%) of Hodgkins lymphoma were diagnosed exclusively on bone marrow biopsy.Conclusions: Bone marrow aspiration and biopsy are complimentary to each other in diagnosing hematological disorders with biopsy being gold standard in the assessment of cellularity, pattern, extent of tumor infiltration and focal infiltration. It is more helpful in diagnosing granulomatous pathology and metastatic deposits of tumors eliciting fibrotic response.

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Section: Discussionmentioning

confidence: 99%

Bone marrow profile in hematological disorders: an experience from a tertiary care centre

Bashir

Musharaf

Reshi³

et al. 2018

Int J Adv Med

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“…Increased mixed pattern of (nodular and interstitial) in Kumar et al, study can be also attributed to the inclusion of high number of CLL patients. [10,13] In the current study 15 [9] In the current study, patients with positive Bsymptoms showed bone marrow infiltration were (55%) and patients with negative Bsymptoms were (45%). Difference between patients with or without B-symptoms was statistically non-significant as regards bone marrow infiltration (p: 0.387).…”

Section: -138-mentioning

confidence: 74%

“…[8] Also in a study by Kumar et al, who report that the incidence of DLBCL in his work was 9/19 (47.37%) that invade the bone marrow. [10] In other work by Elrefaey et al, DLBCL cases that showed infiltration of bone marrow were 8/59 (13.5%). [9] Also study by Campbell et al, who reported that (11%) of DLBCL involved the marrow.…”

Section: -138-mentioning

confidence: 89%

Diagnostic and Prognostic Significance of Bone Marrow Biopsy in Non Hodgkins Lymphoma

Ahmad

Esh

Khorshed

et al. 2017

Zagazig University Medical Journal

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Background: Trephine bone marrow biopsy is the standard method for the diagnosis of neoplasia. In the last few years its role has been defined further by the widespread introduction of immunohistochemistry (IHC), the method that increased the diagnostic power of the trephine bone marrow biopsy by detecting specific antigens in the tumor tissue using nonflourescent chromogens that can be seen by conventional microscopy. Objective: to evaluate the diagnostic and prognostic significance of bone marrow biopsy in non-Hodgkin's lymphomas. Correlation of bone marrow biopsy finding with other prognostic markers in non-Hodgkin's lymphomas is another aim. Methods:The study was performed on 50 patients of NHL diagnosed by LN histopathology. All patients were subjected to: clinical examination and laboratory investigations including complete blood picture, liver function tests, kidney function tests, Erythrocyte sedimentation rate, serum lactate dehydrogenase, B2 microglobulin, bone marrow aspiration, immunophenotyping of bone marrow aspiration of the disseminated cases, bone marrow trephine biopsy for: histological classification according to WHO, staging of NHL and Immunohistochemical staining for CD3 and CD20. Results: Twenty patients (40%) positive for infiltration on examination of marrow biopsy and 30 patients (60%) were negative. The results of fifty NHL cases showed only in six cases, both bone marrow biopsy and aspiration were positive (12%; 95% CI, 4.0: 22.0), and in 30 out of 50, the two parameters were negative (60%, 95%CI, 46: 54). Thus, the agreement level between BMB and BMA in the diagnosis of NHL was 27% and discrepancies between bone marrow biopsy and aspirate were found in the remainder. In 14 of 50 specimens, BMB alone was positive (28%; 95% CI, 16 : 42). Conclusion: Bone marrow biopsy morphology and immunohistochemical staining remain the cornerstone for proper staging in NHL patients to increase the diagnostic and prognostic accuracy, for appropriate treatment protocols.

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“…Though it can also occur in children and young people in rare cases. DLBCL is an aggressive tumor which can arise in any part of the body (6), and the first sign of this illness is typically the observation of a rapidly growing mass, sometimes the swelling is associated with fever, weight loss, and night sweats. The most typical symptom at the time of diagnosis is a mass that is rapidly developing which is located in a part of the body that includes multiple lymph nodes (7).…”

Section: Introductionmentioning

confidence: 99%

“…Bilateral iliac crest BM biopsies and step sections for morphological view are advocated for optimal specimen and detection of small focal lesions accompanied by fibrosis that may not be readily detected in aspirate smear preparations, thereby increasing the yield of possible diagnosis and becoming superior to aspiration study (6). …”

Section: Introductionmentioning

confidence: 99%

25 Years Old Women With Inflammatory Low Back Pain

Soltani

Davatchi

2016

Med Arh

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Introduction:Diffuse large B-cell lymphoma (DLBCL) is the most frequent histological type of malignant lymphomas (approximately 30% of cases). DLBCL is highly curable through chemotherapy. Rituximab in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy as the most frequent of care for first - DLBCL therapy, improves long-term survival of patients effectively.Case report:A young female (25 years old) complained about pain in her right back for two years. She was suffering from backache with priority in the right and contracture in mornings. Sacroiliac joint seemed normal but lytic and sclerotic lesions and also density changing of L5 and humerus head was revealed by CT scan. Biopsy was taken from the iliac bone and diffuse large B cell lymphoma was diagnosed.Conclusion:Chronic pains especially in axial skeleton, pelvis area and main joints must be taken seriously and examined by CT scan and MRI. If no particular issue was reported primarily while the pain was remained, a complete diagnosis BMB associated with PET must be applied. Despite of dependency on diagnosis the treatment by CHOP in association with rituximab is the most recommended chemotherapy alternative for patients with DLBCL.

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Bone marrow biopsy in non-Hodgkin lymphoma: A morphological study

Abstract: Critical examination of BM biopsies can increase the diagnostic accuracy, thereby contributing to the prognosis and appropriate treatment modalities.

Cited by 25 publications

References 0 publications

Bone marrow profile in hematological disorders: an experience from a tertiary care centre

Bone marrow profile in hematological disorders: an experience from a tertiary care centre

Diagnostic and Prognostic Significance of Bone Marrow Biopsy in Non Hodgkins Lymphoma

25 Years Old Women With Inflammatory Low Back Pain

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