Bone-marrow-derived cell-released extracellular vesicle miR-92a regulates hepatic pre-metastatic niche in lung cancer

Hsu, Ya‐Ling; Huang, Ming-Shyan; Hung, Jen‐Yu; Chang, Wei‐An; Tsai, Yi-Hsuan; Pan, Yi-Chung; Lin, Yi-Shiuan; Tsai, Hung-Pei; Kuo, Po‐Lin

doi:10.1038/s41388-019-1024-y

Cited by 55 publications

(43 citation statements)

References 39 publications

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“…EV-miR-19 from astrocytes inhibits PTEN expression in metastatic tumor cells, and the tumor cells with PTEN loss recruit IBA1 + myeloid cells to increase proliferation and suppress apoptosis of themselves by secreting chemokine CCL2, thereby promoting brain metastasis in vivo [178]. EV-miR-92a from CD11b + populations of bone-marrow derived cells (BMDCs) induces collagen type I expression and activation of hepatic stellate cells (HSCs) as well as lung cancer cell attachment on HSCs by targeting SMAD7, potentially leading to recruitment of granulocytic myeloid-derived suppressor cells (MDSCs), a immunosuppressive cell type, and liver metastasis in vivo [179].…”

Section: Regulation Of Malignant Phenotypes Of Cancer Cells By Tumor mentioning

confidence: 99%

Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology

et al. 2020

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Extracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally divided into exosomes and microvesicles on basis of their origination from the endosomal membrane or the plasma membrane, respectively. EV-mediated bidirectional communication among various cell types supports cancer cell growth and metastasis. EVs derived from different cell types and status have been shown to have distinct RNA profiles, comprising messenger RNAs and non-coding RNAs (ncRNAs). Recently, ncRNAs have attracted great interests in the field of EV-RNA research, and growing numbers of ncRNAs ranging from microRNAs to long ncRNAs have been investigated to reveal their specific functions and underlying mechanisms in the tumor microenvironment and premetastatic niches. Emerging evidence has indicated that EV-RNAs are essential functional cargoes in modulating hallmarks of cancers and in reciprocal crosstalk within tumor cells and between tumor and stromal cells over short and long distance, thereby regulating the initiation, development and progression of cancers. In this review, we discuss current findings regarding EV biogenesis, release and interaction with target cells as well as EV-RNA sorting, and highlight biological roles and molecular mechanisms of EV-ncRNAs in cancer biology.

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Section: Regulation Of Malignant Phenotypes Of Cancer Cells By Tumor mentioning

confidence: 99%

Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology

et al. 2020

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“…Characterized by inflammation, angiogenesis, immunosuppression, and organotropism, pre-metastatic niche is used to spread tumor cells (9)(10)(11). It has been confirmed that exosomes secreted by primary tumor site possibly contribute to the establishment of premetastatic niche (12)(13)(14). Various bioactive molecules, such as proteins, RNAs, cholesterol, etc., are encapsulated by exosomes and transported to adjacent cells or distant tissues to optimize tumor microenvironment (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Exosome-Derived LncRNAs in Lung Cancer

Fan

Sun

2020

Front. Oncol.

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As extracellular vesicles, exosomes are released from most cells to perform cell-cell communication. Recent studies have shown that exosomes could be released into tumor microenvironment and blood to promote tumor progression through packaging and transmitting various bioactive molecules, such as cholesterol, proteins, lipids, miRNAs, mRNAs, and long non-coding RNAs (lncRNAs) to distant cells. LncRNAs have emerged as a major class of non-coding transcripts. A lot of LncRNAs have been discovered during the past few years of research on genomics. They have been proven to participate in various biological functions and disease processes through multiple mechanisms. In this review, we analyzed the role of exosome-derived lncRNAs in lung carcinogenesis and metastasis. We also highlight opportunities for the clinical potential of exosomes with specific lncRNAs as biomarkers and therapeutic intervention in lung cancer.

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“…Secretion of EV miR-92 by BMDCs suppresses SMAD7, leading to the enhancement of TGF-B signaling in hepatic stellate cells [ 163 ]. A TGF-β signature predicts clinical outcomes to durvalumab in HIV-1 cancer patients [ 164 ]…”

Section: Transforming Growth Factor-β Signaling In K-ras Mutationmentioning

confidence: 99%

Non-Small-Cell Lung Cancer Signaling Pathways, Metabolism, and PD-1/PD-L1 Antibodies

Santarpía

Aguilar

Chaib

et al. 2020

Cancers

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Treatment of advanced (metastatic) non-small-cell lung cancer (NSCLC) is currently mainly based on immunotherapy with antibodies against PD-1 or PD-L1, alone, or in combination with chemotherapy. In locally advanced NSCLC and in early resected stages, immunotherapy is also employed. Tumor PD-L1 expression by immunohistochemistry is considered the standard practice. Response rate is low, with median progression free survival very short in the vast majority of studies reported. Herein, numerous biological facets of NSCLC are described involving driver genetic lesions, mutations ad fusions, PD-L1 glycosylation, ferroptosis and metabolic rewiring in NSCLC and lung adenocarcinoma (LUAD). Novel concepts, such as immune-transmitters and the effect of neurotransmitters in immune evasion and tumor growth, the nascent relevance of necroptosis and pyroptosis, possible new biomarkers, such as gasdermin D and gasdermin E, the conundrum of K-Ras mutations in LUADs, with the growing recognition of liver kinase B1 (LKB1) and metabolic pathways, including others, are also commented. The review serves to charter diverse treatment solutions, depending on the main altered signaling pathways, in order to have effectual immunotherapy. Tumor PDCD1 gene (encoding PD-1) has been recently described, in equilibrium with tumor PD-L1 (encoded by PDCD1LG1). Such description explains tumor hyper-progression, which has been reported in several studies, and poises the fundamental criterion that IHC PD-L1 expression as a biomarker should be revisited.

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Bone-marrow-derived cell-released extracellular vesicle miR-92a regulates hepatic pre-metastatic niche in lung cancer

Cited by 55 publications

References 39 publications

Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology

Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology

Exosome-Derived LncRNAs in Lung Cancer

Non-Small-Cell Lung Cancer Signaling Pathways, Metabolism, and PD-1/PD-L1 Antibodies

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