Bone Marrow-Derived Cells in Endometrial Cancer Pathogenesis: Insights from Breast Cancer

Ferrer, Alejandra I.; Einstein, Ella; Morelli, Sara S.

doi:10.3390/cells11040714

Cited by 3 publications

(2 citation statements)

References 132 publications

(159 reference statements)

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“…Indeed, BM-derived progenitor cells are involved in the post-partum remodeling of the uterus [ 102 , 103 ], as well as being able to repair damaged endometrium in a rat model [ 104 ]. With respect to pathological processes, one of the most popular theories for the etiology of endometriosis, the formation of endothelial tissue outside of its appropriate location in the uterus, has been owed to the trafficking of stem cells from the BM to other bodily sites, followed by differentiation of these cells into endometrial cells, at locations outside the uterus [ 105 ]. However, whether these findings are also applicable to humans, especially when accounting for the differences between mouse estrous and human menstruation periods, should be further investigated.…”

Section: Utero-cardiac Axis Involves a 3-way Relationship Between Hea...mentioning

confidence: 99%

Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow

Hatta

Yao

2022

Cells

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Clinical evidence suggests that the prevalence of cardiac disease is lower in premenopausal women compared to postmenopausal women and men. Although multiple factors contribute to this difference, uterine stem cells may be a major factor, as a high abundance of these cells are present in the uterus. Uterine-derived stem cells have been reported in several studies as being able to contribute to cardiac neovascularization after injury. However, our studies uniquely show the presence of an “utero-cardiac axis”, in which uterine stem cells are able to home to cardiac tissue to promote tissue repair. Additionally, we raise the possibility of a triangular relationship among the bone marrow, uterus, and heart. In this review, we discuss the exchange of stem cells across different organs, focusing on the relationship that exists between the heart, uterus, and bone marrow. We present increasing evidence for the existence of an utero-cardiac axis, in which the uterus serves as a reservoir for cardiac reparative stem cells, similar to the bone marrow. These cells, in turn, are able to migrate to the heart in response to injury to promote healing.

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Section: Utero-cardiac Axis Involves a 3-way Relationship Between Hea...mentioning

confidence: 99%

Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow

Hatta

Yao

2022

Cells

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“…ERs have two family members (ERα and ERβ), which belong to the nuclear receptor subfamily 3 group A. ERs play crucial roles in breast cancer, endometrial cancer, and osteoporosis (Ferrer et al, 2022; Jin et al, 2021; Wu et al, 2021). ERα expression and absence of ERβ expression are associated with a poorer prognosis in non‐small cell lung cancer.…”

Section: Circadian Clock Regulated Nuclear Receptors In Cancermentioning

confidence: 99%

Circadian clock‐mediated nuclear receptors in cancer

Niu

Táng

2022

Journal Cellular Physiology

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Circadian system coordinates the daily periodicity of physiological and biochemical functions to adapt to environmental changes. Circadian disruption has been identified to increase the risk of cancer and promote cancer progression, but the underlying mechanism remains unclear. And further mechanistic understanding of the crosstalk between clock components and cancer is urgent to achieve clinical anticancer benefits from chronochemotherapy. Recent studies discover that several nuclear receptors regulating circadian clock, also play crucial roles in mediating multiple cancer processes. In this review, we aim to summarize the latest developments of clock-related nuclear receptors in cancer biology and dissect mechanistic insights into how nuclear receptors coordinate with circadian clock to regulate tumorigenesis and cancer treatment. A better understanding of circadian clock-related nuclear receptors in cancer could help prevent tumorigenesis and improve anticancer efficacy.

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Pan-cancer study on transition of signaling systems from primary to metastatic tumors

Zhou,

Zhang

2024

Preprint

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Metastatic progression is responsible for the majority of cancer-related deaths. A better understanding of the underlying molecular mechanisms driving metastasis therefore remains of utmost importance. Here we take efforts to excavate mutant driver factors of metastases in the level of signaling pathways. We introduce two models, EntCDP and ModSDP, to detect the similarity and specificity of pathways in a pan-cancer context. The simulation studies confirm their feasibility and identification accuracy. Using mutation profiles of 17 cancer types with primary and metastatic cohorts from MSK-IMPACT, we apply the two models to investigate the transition of signaling systems from primary to metastatic tumors mainly from five perspectives. 1) We initially perform a comprehensive comparison of 15 primary-metastatic cancer pairs. Nearly all shared common driver genes or pathways, while specific driver gene sets of primary or/and metastatic tumors can be seen for almost each pair, except for breast cancer. 2) We use ModSDP to identify the specificity of metastases with the same primary site and highlight calcium signaling in breast cancer with bone metastasis, FoxO signaling for melanoma/lung lymph node metastasis, etc. 3) Oppositely, we use EntCDP to identify common factors yielding three frequently metastatic sites (liver, lung and brain), and recognized cushing syndrome, microRNAs in cancer and MAPK signaling pathway, separately. 4) Regarding high-tropism metastatic patterns, we investigated the relationship between the metastatic tumor and primary tumors in both locations. In the typical pattern of colorectal cancer metastasis to the liver, we detected hepatic signals in primary colorectal cancer. 5) Finally, we focused on the common and specific characteristics of relevant cancer types, such as gender-related cancers and gastrointestinal cancers. Study on gynecologic tumors suggest endocrine hormone change and virus infection as their common risk factors, while for male we highlight hedgehog signaling and EPH-related receptors as invasive potential of prostate cancer. Multiple interesting findings revealed by this study may be helpful for the understanding of the extent of signal changes during tumor metastasis. We expect that this study will provide a valuable resource for transforming our knowledge about signals in cancer metastasis into alternative clinical practice for advanced patients.

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Bone Marrow-Derived Cells in Endometrial Cancer Pathogenesis: Insights from Breast Cancer

Cited by 3 publications

References 132 publications

Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow

Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow

Circadian clock‐mediated nuclear receptors in cancer

Pan-cancer study on transition of signaling systems from primary to metastatic tumors

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