Bone marrow-derived progenitor cells promote corneal wound healing following alkali injury

Ye, Juan; Lee, Sang Yeul; Kook, Koung Hoon; Yao, Ke

doi:10.1007/s00417-007-0716-0

Cited by 31 publications

(25 citation statements)

References 15 publications

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“…We chose to administer the MSCs before transplantation (day À7) as previous studies have shown enhanced efficacy when applied pretransplantation in preclinical models of cardiac (34) and kidney (35) transplantation. To date, a number of groups have investigated the ability of MSCs to repair chemically damaged corneas (20,(36)(37)(38) but relatively few have reported on the effects of MSCs on corneal allograft survival (22,39). To our knowledge, we show here for the first time that MSCs derived from a thirdparty strain are effective in prolonging corneal allograft survival.…”

Section: Discussionmentioning

confidence: 72%

Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation

Treacy

O’Flynn

Ryan

et al. 2014

American Journal of Transplantation

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y These authors contributed equally to this work.Mesenchymal stem cells (MSCs) are being investigated extensively due to their ability to dampen immune responses. Here, we tested the ability of MSCs from three distinct sources to prolong rat corneal allograft survival. A fully allogeneic rat cornea transplant model (DA to LEW) was used. Recipient rats received 1 Â 10 6 MSCs (syn [LEW], allo [DA] or third-party [Wistar Furth]) intravenously 7 days before transplantation and again on the day of transplantation (day 0). A high percentage of untreated and syn-MSC treated allografts were rejected (80% and 100%, respectively). Preactivation of syn-MSCs with interferon gamma also failed to prolong allograft survival. Conversely, corneal allograft survival was significantly prolonged in allo-MSC treated (90%) and third-party MSC treated (80%) allograft recipients. Flow cytometric analysis revealed less infiltrating natural killer T cells in corneas of both allo-and third-party MSC treated animals, coupled with a higher proportion of splenic CD4þFoxp3þ regulatory T cells, compared to controls. In the case of allo-and third-party MSCs, results from a delayed-type hypersensitivity assay clearly showed that hypo-responsiveness was specific for corneal donor-associated alloantigens. Thus, allo-and third-party MSC treatment prolongs corneal allograft survival by suppressing peripheral immune responses and promoting an intragraft immunoregulatory milieu.

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Section: Discussionmentioning

confidence: 72%

Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation

Treacy

O’Flynn

Ryan

et al. 2014

American Journal of Transplantation

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“…26 Bone marrow-derived progenitor cells home to corneal alkali injuries and promote wound healing. 27 Following RPE injury bone marrow-derived cells migrate into the eye and adopt RPE characteristics. [28][29][30][31] This raises the possibility that cells seen proliferating along the surface of the retina and along the back surface of the vitreous cone may also have originated, in part, from bone marrow-derived progenitor cells.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural Correlation of Spectral-Domain Optical Coherence Tomographic Findings in Vitreomacular Traction Syndrome

Chang¹,

Fine²,

Spaide³

et al. 2008

American Journal of Ophthalmology

110

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PURPOSE-To examine the ultrastructural correlates of spectral-domain optical coherence tomography (SD-OCT) findings in patients with vitreomacular traction (VMT). DESIGN-Observational case series.METHODS-Retrospective analysis of six eyes of consecutive patients who underwent vitrectomy surgery for VMT was performed in this single-center, noncomparative study. One patient had a concurrent macular hole. Preoperative assessment included SD-OCT examination with 3-dimensional image reconstruction. During surgery the vitreous cone was dissected from the vitreous body using scissors, then removed from the surface of the retina with a combination of sharp dissection and peeling, and subsequently submitted for histologic and transmission electron microscopic processing. RESULTS-SD-OCTshowed prominent vitreal-foveal adhesion in all six eyes. Each eye had an epiretinal membrane (ERM) under the detached perifoveal posterior vitreous detachment. In all eyes this ERM appeared to course up the cone of attached vitreous and along the back surface of the posterior vitreous face. Ultrastructural analysis showed fibrocellular proliferations in the vitreous specimens in all six cases, which included retinal pigment epithelium (RPE) cells (five eyes), fibrocytes (four eyes), and macrophages (three eyes). CONCLUSIONS-The adhesion between the vitreous and fovea in vitreomacular traction syndrome is accompanied by fibrocellular proliferation along the exposed surfaces of the inner retina and the posterior surface of the vitreous. This fibrocellular proliferation may augment the adhesion between the vitreous and fovea, and may account for the prominent OCT signal seen along the posterior surface of the vitreous in these cases. Vitreomacular traction (VMT) syndrome results from persistent vitreoretinal adhesions in the setting of partial posterior vitreous detachment (PVD). The vitreoretinal adhesions transmit tractional forces to the retina from the vitreous body, having the potential to cause tensile deformation, foveal cavitation, cystoid macular edema, limited macular detachment, or macular hole (MH) formation. 1,2 Our understanding of VMT has been enhanced by the development of optical coherence tomography (OCT), a noninvasive method of imaging intraocular tissues. [3][4][5][6][7][8][9][10][11] Inquiries to Richard F. Spaide, Vitreous, Retina, Macula Consultants of New York, 460 Park Avenue, 5th Floor, New York, NY 10022; rickspaide@yahoo.com. Idiopathic epiretinal membrane (ERM) proliferation is another vitreoretinal interface abnormality that is often considered to be distinct from VMT. 1 Astrocytes, myofibroblasts, and fibrocytes predominate in VMT 1,11-14 while retinal pigment epithelium (RPE) cells are commonly found in ERMs. 2,[15][16][17][18] However, a recent study with spectral-domain (SD) OCT showed similarities between the anatomic features of these two entities. 19 In the current study, we performed preoperative SD-OCT and transmission electron microscopy (TEM) of surgically excised specimens from patients with ...

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“…Corneal injury results in the release of specific chemoattractants, which cause bone marrow to mobilize endogenous MSCs into the peripheral blood. Thus, circulating MSCs increase in number and migrate to the local injured cornea but not the healthy cornea [16,38] . The chemokine SDF-1 and substance P in the cauterized cornea are involved in regulating the mobilization and recruitment of MSCs to corneal injury sites [16] .…”

Section: Msc Mobilization and Homingmentioning

confidence: 99%

Mesenchymal stem cells: Potential role in corneal wound repair and transplantation

Li¹

2014

WJSC

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Corneal diseases are a major cause of blindness in the world. Although great progress has been achieved in the treatment of corneal diseases, wound healing after severe corneal damage and immunosuppressive therapy after corneal transplantation remain problematic. Mesenchymal stem cells (MSCs) derived from bone marrow or other adult tissues can differentiate into various types of mesenchymal lineages, such as osteocytes, adipocytes, and chondrocytes, both in vivo and in vitro . These cells can further differentiate into specific cell types under specific conditions. MSCs migrate to injury sites and promote wound healing by secreting anti-inflammatory and growth factors. In addition, MSCs interact with innate and acquired immune cells and modulate the immune response through their powerful paracrine function. Over the last decade, MSCs have drawn considerable attention because of their beneficial properties and promising therapeutic prospective. Furthermore, MSCs have been applied to various studies related to wound healing, autoimmune diseases, and organ transplantation. This review discusses the potential functions of MSCs in protecting corneal tissue and their possible mechanisms in corneal wound healing and corneal transplantation.

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Bone marrow-derived progenitor cells promote corneal wound healing following alkali injury

Cited by 31 publications

References 15 publications

Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation

Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation

Ultrastructural Correlation of Spectral-Domain Optical Coherence Tomographic Findings in Vitreomacular Traction Syndrome

Mesenchymal stem cells: Potential role in corneal wound repair and transplantation

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