Bone Marrow Edema Pattern Identification in Patients With Lytic Bone Lesions Using Digital Subtraction Angiography–Like Bone Subtraction on Large-Area Detector Computed Tomography

Teixeira, Pedro Augusto Gondim; Hossu, Gabriela; Lecocq, S.; Razeto, Marco; Louis, M.; Blum, Alain

doi:10.1097/rli.0000000000000007

Cited by 13 publications

(9 citation statements)

References 27 publications

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“…BSI images generated by area detector CT allow bone removal (both cortical and trabecular) without affecting the visualization of contrast enhancement in a nonlytic bone background. [12][13][14] BSI imaging may be helpful for the diagnosis of bone invasion with or without erosive changes in cortical bone.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, digital subtraction angiography-like bone subtraction iodine (BSI) imaging with 160-mm-wide area detector CT is used in some musculoskeletal and neurologic applications. [12][13][14] According to Gondim Teixeira et al, 12 BSI imaging with area detector CT showed high performance for the visual identification of bone marrow enhancement adjacent to lytic bone lesions. This technique reduces spatial mismatch by using volume scanning with wide area detector CT and a high-resolution deformable registration algorithm, enabling identification of contrast enhancement in the bone marrow.…”

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confidence: 99%

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Bone Subtraction Iodine Imaging Using Area Detector CT for Evaluation of Skull Base Invasion by Nasopharyngeal Carcinoma

Hiyama

Kuno

Koike

et al. 2018

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Conventional CT has generally lower detectability of bone marrow invasion than MR imaging due to lower tissue contrast. The purpose of this study was to compare the diagnostic performance of conventional CT alone or in combination with bone subtraction iodine imaging using area detector CT for the evaluation of skull base invasion in patients with nasopharyngeal carcinoma. MATERIALS AND METHODS: Forty-four consecutive patients who underwent contrast-enhanced CT using 320-row area detector CT and contrast-enhanced MR imaging for nasopharyngeal carcinoma staging between April 2012 and November 2017 were enrolled in this retrospective study. Bone subtraction iodine images were generated by subtracting pre-and postcontrast volume scans using a highresolution deformable registration algorithm. Two blinded observers evaluated skull base invasion at multiple sites (sphenoid body, clivus, bilateral base of the pterygoid process, and petrous bone) using conventional CT images alone or in combination with bone subtraction iodine images. Examination of MR and CT images by an experienced neuroradiologist was the reference standard for evaluating sensitivity, specificity, and area under the receiver operating characteristic curve. RESULTS: Twenty-six patients (59%) showed skull base invasion at 84 sites on the reference standard. Conventional CT plus bone subtraction iodine images showed higher sensitivity (92.9% versus 78.6%, P ϭ .02) and specificity (95.6% versus 86.1%, P ϭ .01) than conventional CT images alone for evaluating skull base invasion. The area under the receiver operating characteristic curve for conventional CT plus bone subtraction iodine (0.98) was significantly larger (P Ͻ .001) than the area under the receiver operating characteristic curve for conventional CT alone (0.90). CONCLUSIONS: Conventional CT plus bone subtraction iodine performs more closely to the accuracy of combining CT and MR imaging compared with conventional CT alone. ABBREVIATIONS: AUC ϭ area under the receiver operating characteristic curve; BSI ϭ bone subtraction iodine; CCT ϭ conventional CT; NPC ϭ nasopharyngeal carcinoma N asopharyngeal carcinoma (NPC), arising from the epithelial lining of the nasopharynx, has a propensity to invade the skull base just above the nasopharynx. Skull base invasion indicates a tumor stage of at least T3 according to the eighth edition of

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Bone Subtraction Iodine Imaging Using Area Detector CT for Evaluation of Skull Base Invasion by Nasopharyngeal Carcinoma

Hiyama

Kuno

Koike

et al. 2018

AJNR Am J Neuroradiol

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“…SII has been used for visualizing contrast enhancement in bone [ 18 – 21 , 23 ]. One study reported that the extent of bone marrow infiltration by nasopharyngeal carcinoma was visualized on SII by accentuating contrast enhancement and suppressing normal bony tissues [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Subtraction iodine imaging (SII) is employed in several musculoskeletal and neurological applications [ 18 – 21 ]. SII is generated by subtracting the pre-contrast CT from the post-contrast enhanced CT.…”

Section: Introductionmentioning

confidence: 99%

Subtraction iodine imaging with area detector CT to improve tumor delineation and measurability of tumor size and depth of invasion in tongue squamous cell carcinoma

et al. 2021

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Purpose Tumor size and depth of invasion (DOI) are mandatory assessments for tumor classification in tongue cancer but are often non-assessable on CT due to dental artifacts. This study investigated whether subtraction iodine imaging (SII) would improve tumor delineation and measurability. Materials and methods Fifty-seven consecutive patients with tongue cancer, who underwent scanning with a 320-row area detector CT with contrast administration and were treated with surgical resection, were retrospectively evaluated. CT was reconstructed with single-energy projection-based metallic artifact reduction (sCT). SII was generated by subtracting the pre-contrast volume scans from the post-contrast volume scans using a high-resolution deformable registration algorithm. MRI scans were also evaluated for comparing the ability of measurements. Two radiologists visually graded the tumor delineation using a 5-point scale. Tumor size and DOI were measured wherever possible. The tumor delineation score was compared using the Wilcoxon signed-rank method. Spearman’s correlations between imaging and pathological measurements were calculated. Intraclass correlation coefficients of measurements between readers were estimated. Results The tumor delineation score was greater on sCT-plus-SII than on sCT alone (medians: 3 and 1, respectively; p < 0.001), with higher number of detectable cases observed with sCT-plus-SII (36/57 [63.2%]) than sCT alone (21/57 [36.8%]). Tumor size and DOI measurability were higher with sCT-plus-SII (29/57 [50.9%]) than with sCT alone (17/57 [29.8%]). MRI had the highest detectability (52/57 [91.2%]) and measurability (46/57 [80.7%]). Correlation coefficients between radiological and pathological tumor size and DOI were similar for sCT (0.83–0.88), sCT-plus-SII (0.78–0.84), and MRI (0.78–0.90). Intraclass correlation coefficients were higher than 0.95 for each modality. Conclusions SII improves detectability and measurability of tumor size and DOI in patients with oral tongue squamous cell carcinoma, thus increasing the diagnostic potential. SII may also be beneficial for cases unevaluable on MRI due to artifacts or for patients with contraindications to MRI.

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“…Since several minutes can elapse between two CT scans, interscan motion artifacts induced by breathing, organ pulsation, or patient movement might degrade ablation zone monitoring. To minimize such artifacts, adequate registration of successively acquired images is necessary [5,6,[18][19][20] The aim of image registration is to match structures or features between the individual images to obtain diagnostic image quality [21,22]. Two major types of image registration algorithms are available: rigid and elastic registration [23].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Different Registration Algorithms to Reduce Motion Artifacts in CT-Thermography (CTT)

Kostyrko,

Rubarth,

Althoff

et al. 2023

Diagnostics

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Computed tomography (CT)-based Thermography (CTT) is currently being investigated as a non-invasive temperature monitoring method during ablation procedures. Since multiple CT scans with defined time intervals were acquired during this procedure, interscan motion artifacts can occur between the images, so registration is required. The aim of this study was to investigate different registration algorithms and their combinations for minimizing inter-scan motion artifacts during thermal ablation. Four CTT datasets were acquired using microwave ablation (MWA) of normal liver tissue performed in an in vivo porcine model. During each ablation, spectral CT volume scans were sequentially acquired. Based on initial reconstructions, rigid or elastic registration, or a combination of these, were carried out and rated by 15 radiologists. Friedman’s test was used to compare rating results in reader assessments and revealed significant differences for the ablation probe movement rating only (p = 0.006; range, 5.3–6.6 points). Regarding this parameter, readers assessed rigid registration as inferior to other registrations. Quantitative analysis of ablation probe movement yielded a significantly decreased distance for combined registration as compared with unregistered data. In this study, registration was found to have the greatest influence on ablation probe movement, with connected registration being superior to only one registration process.

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Bone Marrow Edema Pattern Identification in Patients With Lytic Bone Lesions Using Digital Subtraction Angiography–Like Bone Subtraction on Large-Area Detector Computed Tomography

Cited by 13 publications

References 27 publications

Bone Subtraction Iodine Imaging Using Area Detector CT for Evaluation of Skull Base Invasion by Nasopharyngeal Carcinoma

Bone Subtraction Iodine Imaging Using Area Detector CT for Evaluation of Skull Base Invasion by Nasopharyngeal Carcinoma

Subtraction iodine imaging with area detector CT to improve tumor delineation and measurability of tumor size and depth of invasion in tongue squamous cell carcinoma

Evaluation of Different Registration Algorithms to Reduce Motion Artifacts in CT-Thermography (CTT)

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