Bone marrow findings in systemic mastocytosis

Horny, Hans Peter; Parwaresch, M. R.; Lennert, K.

doi:10.1016/s0046-8177(85)80252-5

Cited by 247 publications

(141 citation statements)

References 24 publications

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“…20 -22 SM is a clonal hematological disease that almost invariably affects the BM. [1][2][3][4][11][12][13][14]24 In the present study, we show that the BM MVD is significantly higher in SM compared to CM/UP or controls. This observation is novel and is in line with the notion that SM is a neoplastic hematological disease.…”

Section: Discussionsupporting

confidence: 64%

Increased Angiogenesis in the Bone Marrow of Patients with Systemic Mastocytosis

Wimazal

Jordan

Sperr

et al. 2002

The American Journal of Pathology

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Recent data suggest that angiogenesis in the bone marrow (BM) is augmented and associated with growth of neoplastic cells in various hematological malignancies. Systemic mastocytosis (SM) is a neoplasm affecting multilineage and mast cell (MC)-committed hemopoietic progenitors. In the present study, we have assessed the BM microvessel density (MVD) by CD34 immunohistochemistry in 21 patients with SM, 5 with cutaneous mastocytosis (no BM infiltrates), and 5 control cases (normal BM). The median BM MVD was significantly higher in SM compared to cutaneous mastocytosis or controls (P < 0.05). In addition, a significant correlation (r ‫؍‬ 0.74) between the BM MVD and grade of MC infiltration (percent tryptase ؉ BM infiltrates) was found in SM. Moreover, the MVD was higher in MC infiltrates compared to the nonaffected adjacent marrow (P < 0.05). Immunohistochemical staining revealed expression of vascular endothelial growth factor in MC infiltrates. The notion that SM is associated with increased BM angiogenesis and vascular endothelial growth factor expression may have implications for the biology of disease and development of new treatment strategies.

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Section: Discussionsupporting

confidence: 64%

Increased Angiogenesis in the Bone Marrow of Patients with Systemic Mastocytosis

Wimazal

Jordan

Sperr

et al. 2002

The American Journal of Pathology

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“…In most patients with MCL, the BM is heavily infiltrated by atypical, immature MCs which is demonstrable by histological and immunohistochemical staining of paraffin-embedded BM sections [1][2][3][4][14][15][16][17]. The MC infiltration is usually multifocal and dense with an additional diffuse component (mixed infiltration pattern) [14][15][16][17][18].…”

Section: Histomorphologic and Immunohistochemical Properties Of Mcs Imentioning

confidence: 99%

“…The MC infiltration is usually multifocal and dense with an additional diffuse component (mixed infiltration pattern) [14][15][16][17][18]. In contrast to patients with indolent SM, the normal architecture of the BM is completely replaced by the leukemic infiltrate.…”

Section: Histomorphologic and Immunohistochemical Properties Of Mcs Imentioning

confidence: 99%

Chronic mast cell leukemia: A novel leukemia-variant with distinct morphological and clinical features

Valent¹,

Sotlar²,

Sperr³

et al. 2015

Leukemia Research

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SummaryMast cell leukemia (MCL) is a rare form of systemic mastocytosis characterized by leukemic expansion of mostly immature mast cells, organ damage, drug-resistance, and a poor prognosis. Even when treated with chemotherapy, most patients have a life-expectancy of less than one year. However, there are rare patients with MCL in whom the condition is less aggressive and does not cause organ damage within a short time. In these patients, mast cells exhibit a more mature morphology when compared to acute MCL. A recently proposed classification suggests that these cases are referred to as chronic MCL. In the present article, we discuss clinical, histopathological and morphological aspects of acute and chronic MCL.

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“…Furthermore, allergic asthma, a condition characterized by mast cell activation, shows increased production of collagens and extracellular matrix (ECM) 3 proteins as well as subepithelial fibrosis (6). Fibrosis also occurs in the skin of patients with atopic dermatitis (7) and in mastocytosis patients (8).…”

mentioning

confidence: 99%

Mast Cell-Fibroblast Interactions Induce Matrix Metalloproteinase-9 Release from Fibroblasts: Role for IgE-Mediated Mast Cell Activation

Abel

Vliagoftis

2008

The Journal of Immunology

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Mast cells adhere to fibroblasts, but the biological effects of adhesion are not well understood. We hypothesized that these adhesive interactions are important for tissue remodeling through the release of matrix metalloproteinases (MMP). Murine bone marrow cultured mast cells (BMCMC) were cocultured with NIH-3T3 fibroblasts or murine lung fibroblasts (CCL-206) and supernatants analyzed for MMP-9 release by gelatin zymography. Coculture of BMCMC for 24 h with NIH-3T3 or CCL-206 fibroblasts increased the release of MMP-9 from fibroblasts by 1.7 ± 0.2 and 2.0 ± 0.7-fold, respectively. Coculture of BMCMC and fibroblasts in the presence of IgE increased further MMP-9 release, which was released by fibroblasts. MMP-9 release was dependent on TNF released from IgE activated BMCMC and on adhesive interactions between BMCMC and fibroblasts. Increased MMP-9 release was also p44/42-dependent, as was MMP-9 up-regulation during coculture of fibroblasts with resting BMCMC. Finally, IgE injection into the mouse ear increased MMP-9 content of the ear tissue in the absence of Ag, indicating that IgE-mediated remodeling may play a pathogenic role in allergic conditions even in the absence of exposure to allergens. In conclusion, mast cell-fibroblast interactions induce the release of proteases important for tissue remodeling, such as MMP-9. MMP-9 release was further increased in the presence of IgE during coculture, suggesting a role for mast cell-fibroblast interactions in atopic conditions.

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Bone marrow findings in systemic mastocytosis

Cited by 247 publications

References 24 publications

Increased Angiogenesis in the Bone Marrow of Patients with Systemic Mastocytosis

Increased Angiogenesis in the Bone Marrow of Patients with Systemic Mastocytosis

Chronic mast cell leukemia: A novel leukemia-variant with distinct morphological and clinical features

Mast Cell-Fibroblast Interactions Induce Matrix Metalloproteinase-9 Release from Fibroblasts: Role for IgE-Mediated Mast Cell Activation

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