Bone marrow imaging: magnetic resonance studies related to age and sex.

Dooms, Grégoire; Fisher, Madeleine R.; Hricak, Hedvig; Richardson, Michael L.; Crooks, L E; Genant, Harry K.

doi:10.1148/radiology.155.2.3983394

Cited by 177 publications

(70 citation statements)

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“…In particular trabecular thinning, often considered the main cause of bone weakening in osteoporosis disease, causes an increase in the intertrabecular spaces filled compensatorily, as many authors suggest, by increased amount of yellow bone marrow [35,39,40].…”

Section: Correlation Between Marrow Fat Content and Bone Weaknessmentioning

confidence: 99%

Is 3T-MR Spectroscopy a Predictable Selection Tool in Prophylactic Vertebroplasty?

Masala

Massari

Assako

et al. 2010

Cardiovasc Intervent Radiol

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This study was designed to confirm relationships between decrease of bone mineral density and increase of marrow fat and to delineate, through MR spectroscopy, vertebral body at high risk for compression fracture onset to justify prophylactic vertebroplasty. We enrolled 127 women: 48 osteoporotic, 36 osteopenic, and 43 normal subjects, who underwent DXA and MR examination of spine. Then, we selected 48 patients with at least two acute osteoporotic vertebral fractures with interposed normal ''sandwich'' vertebrae; all patients underwent MR examination of spine. Significant statistical differences were found among ''Fat Fraction'' (FF) values in normal, osteopenic, and osteoporotic subjects: 59.8 ± 5.1%; 64.8 ± 4.4%; and 67.1 ± 3.3%. A mild, significant, negative correlation was observed between T-score and vertebral fat content (r = -0.585; P = 0.0000). In the second part of the study, 9 new vertebral fractures were observed in 48 patients (19%): 6 were ''sandwich'' vertebrae (12.5%), and 3 were located in distant vertebral body. The mean FF in sandwich fractured vertebrae was 72.75 ± 1.95 compared with the FF of the nonfractured sandwich, and distant control vertebrae were 61.83 ± 3.42 and 61.42 ± 3.64. We found a significant statistical difference between fractured and nonfractured vertebrae (P \ 0.001). The results of this study suggest that MR spectroscopy could be a reliable index to predict the risk of new compression vertebral fracture and could be used for vertebroplasty planning contributing to clarify the possibility to add prophylactic PVP to standard treatment.

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Section: Correlation Between Marrow Fat Content and Bone Weaknessmentioning

confidence: 99%

Is 3T-MR Spectroscopy a Predictable Selection Tool in Prophylactic Vertebroplasty?

Masala

Massari

Assako

et al. 2010

Cardiovasc Intervent Radiol

View full text Add to dashboard Cite

show abstract

“…MRI was applied for the assessment of bone marrow cellularity since its early time of development [14][15][16] . Bone marrow consists of mostly hematopoietic cells and fat cells filling the available space.…”

Section: Discussionmentioning

confidence: 99%

“…3). This phenomenon can be primarily related to the agedependent decrease of bone marrow cellularity 14,20) . Prominent increase of signal indices in postmenopausal women may be related to the decreased bone density and/ or increased fat content, because T1 signal intensity of the bone marrow is affected by bone density and high calcium or iron deposition in bone matrix [21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

Quantitative Assessment of Bone Marrow Cellularity by Magnetic Resonance Imaging in Workers with Long-Term Exposure to Solvents.

et al. 2004

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This study was conducted to develop a noninvasive method of bone marrow cellularity evaluation in solvent-exposed painters. Six painters with hypocellular marrow and 132 referents were examined using magnetic resonance imaging (MRI). Full examination of the peripheral blood and bone marrow biopsy was done on each patient. Signal indices were calculated from the signal intensities measured at the vertebral bodies from T12 to S1 and on the paraspinal muscles on both the T1-and the T2-weighted image (T1WI and T2WI). Bone marrow cellularities of the painters were between 20.3% and 33.6%. Signal indices at T1WI were greater in the hypocellular marrow cases compared to those of the referents (p<0.05, p<0.01) and were significantly higher in older women compared with men (p<0.05). After adjusting for age and gender, the signal index of cases at S1 of T1WI was higher than that of the referents by 0.364. Five of the six cases had signal index at S1 of T1WI higher than the mean + 1 standard deviation for the same age group and gender. MRI signal indices can be used as a useful indicator of bone marrow cellularity in a high-risk population after adequate adjustment.

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“…The use of ALG alone or together with cyclosporine A is also accepted as an effective form of treatment for patients with SAA who lack HLA-matched donors and who are over 40 yr of age. In normal adults, the distribution of hematopoietic and fatty marrow relative to age has been extensively described (14)(15)(16). Since the hematopoietic marrow remains throughout life in the lumbar spine, the pelvis, and the intertrochanteric area of the femur, these areas were assessed in our study.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging of the Bone Marrow After Bone Marrow Transplantation or Immunosuppressive Therapy in Aplastic Anemia

et al. 2001

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To compare magnetic resonance (MR) images of the bone marrow (BM) after bone marrow transplantation or immunosuppressive therapy in patients with aplastic anemia (AA), MR imaging of BM was reviewed retrospectively in 16 patients (13 males and 3 females, mean age 26 yr) with AA who completely responded clinically after transplantation or immunosuppressive therapy. The signal intensity (SI) of BM was classified into four patterns according to the increasing amount of cellular marrow, i.e., pattern I to IV. SI of MR imaging of BM exhibited an increase of cellular marrows following both transplantation and immunosuppressive therapy. Of the eight patients on transplantation, the SI of the lumbar spinal BM was pattern III in two patients and IV in six on T1-weighted and short tau inversion recovery (STIR) images. In the eight patients with immunosuppressive therapy, the SI of the lumbar spinal BM was pattern II in one, III in five, and IV in two on T1-weighted images and pattern II in one, III in four, and IV in three on STIR images. SI on MR imaging of the lumbar spinal BM showed a more cellular pattern in patients on transplantation than in those on immunosuppressive therapy.

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Bone marrow imaging: magnetic resonance studies related to age and sex.

Cited by 177 publications

References 0 publications

Is 3T-MR Spectroscopy a Predictable Selection Tool in Prophylactic Vertebroplasty?

Is 3T-MR Spectroscopy a Predictable Selection Tool in Prophylactic Vertebroplasty?

Quantitative Assessment of Bone Marrow Cellularity by Magnetic Resonance Imaging in Workers with Long-Term Exposure to Solvents.

Magnetic Resonance Imaging of the Bone Marrow After Bone Marrow Transplantation or Immunosuppressive Therapy in Aplastic Anemia

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