Bone marrow inflammation in haematological malignancies

de Jong, Madelon M. E.; Chen, Lanpeng; Raaijmakers, Marc H. G. P.; Cupedo, Tom

doi:10.1038/s41577-024-01003-x

Cited by 6 publications

(1 citation statement)

References 225 publications

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“…Bone marrow niche is the site where CLL malignancy begins with primary genetic mutations followed by antigen-driven expansion ( 58 , 59 ). The TME of BM is known to contribute not only to the survival of malignant cells ( 60 ), but also to the development of drug resistance ( 61 , 62 ). In CLL, the BM infiltration of CLL cells causes the bone erosion and thinning of the femoral cortex in a xenograft NSG mouse model via the activation of the RANK/RANKL signaling ( 63 ).…”

Section: Mouse Models Of Cllmentioning

confidence: 99%

Mouse models of chronic lymphocytic leukemia and Richter transformation: what we have learnt and what we are missing

Bertilaccio,

Chen

2024

Front. Immunol.

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Although the chronic lymphocytic leukemia (CLL) treatment landscape has changed dramatically, unmet clinical needs are emerging, as CLL in many patients does not respond, becomes resistant to treatment, relapses during treatment, or transforms into Richter. In the majority of cases, transformation evolves the original leukemia clone into a diffuse large B-cell lymphoma (DLBCL). Richter transformation (RT) represents a dreadful clinical challenge with limited therapeutic opportunities and scarce preclinical tools. CLL cells are well known to highly depend on survival signals provided by the tumor microenvironment (TME). These signals enhance the frequency of immunosuppressive cells with protumor function, including regulatory CD4+ T cells and tumor-associated macrophages. T cells, on the other hand, exhibit features of exhaustion and profound functional defects. Overall immune dysfunction and immunosuppression are common features of patients with CLL. The interaction between malignant cells and TME cells can occur during different phases of CLL development and transformation. A better understanding of in vivo CLL and RT biology and the availability of adequate mouse models that faithfully recapitulate the progression of CLL and RT within their microenvironments are “conditio sine qua non” to develop successful therapeutic strategies. In this review, we describe the xenograft and genetic-engineered mouse models of CLL and RT, how they helped to elucidate the pathophysiology of the disease progression and transformation, and how they have been and might be instrumental in developing innovative therapeutic approaches to finally eradicate these malignancies.

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Section: Mouse Models Of Cllmentioning

confidence: 99%

Mouse models of chronic lymphocytic leukemia and Richter transformation: what we have learnt and what we are missing

Bertilaccio,

Chen

2024

Front. Immunol.

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“Hedgehog Ball”-Shaped Nanoprobes for Multimodal Detection and Imaging of Inflammatory Markers in Osteosarcoma Using Fluorescence and Electrochemiluminescence

Zhao,

Ma,

Yang

et al. 2024

Anal. Chem.

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Inflammation can affect the progression of cancer at tumor sites, such as in osteosarcoma, by intensifying metastasis and complicating outcomes. The current diagnostic methods lack the specificity and sensitivity required for early and accurate detection, particularly in differentiating between inflammation-induced changes and tumor activities. To address this, a novel "hedgehog ball"-shaped nanoprobe, Fe 3 O 4 @Au-pep-CQDs, was developed and designed to enhance the detection of caspase-1, a key marker of inflammation. This magnetic nanoprobe facilitates simultaneous fluorescence (FL) and electrochemiluminescence (ECL) detection. Magnetic separation minimizes the quenching of nanoparticles in solution and eliminates the need for frequent electrode replacement in ECL tests, thereby simplifying diagnostic procedures. The experimental results showed that in the detection of caspase-1, the nanoprobe had a detection limit of 0.029 U/mL (FL) and 0.033 U/mL (ECL) and had a dynamic range of 0.05 to 1.0 U/mL. Additionally, the nanoprobe achieved high recovery rates of 94.36 to 102.44% (FL) and 94.36−100.12% (ECL) in spiked biological samples. Furthermore, the nanoprobe's capabilities were extended to in vivo bioimaging to provide direct, intuitive visualization of biological processes. These novel nanoprobes were able to significantly enhance the accurate detection of inflammation at tumor sites, thereby optimizing both diagnostic and therapeutic strategies.

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New horizons in our understanding of precursor multiple myeloma and early interception

Cordas dos Santos,

Toenges,

Bertamini

et al. 2024

Nat Rev Cancer

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Bone marrow inflammation in haematological malignancies

Cited by 6 publications

References 225 publications

Mouse models of chronic lymphocytic leukemia and Richter transformation: what we have learnt and what we are missing

Mouse models of chronic lymphocytic leukemia and Richter transformation: what we have learnt and what we are missing

“Hedgehog Ball”-Shaped Nanoprobes for Multimodal Detection and Imaging of Inflammatory Markers in Osteosarcoma Using Fluorescence and Electrochemiluminescence

New horizons in our understanding of precursor multiple myeloma and early interception

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