Bone Marrow NK Cells: Origin, Distinctive Features, and Requirements for Tissue Localization

Bonanni, Valentina; Sciumé, Giuseppe; Santoni, Angela; Bernardini, Giovanni

doi:10.3389/fimmu.2019.01569

Cited by 35 publications

(31 citation statements)

References 63 publications

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“…These subsets include ILCs1, ILCs2, ILCs3, lymphoid tissue-inducer (LTi) cells, and conventional NK (cNK) cells [ 138 , 139 ]. ILCs interact with the tissue cells to ensure, in addition to the immune response, homeostasis and tissue repair [ 140 , 141 ]. Among these subsets, cNKs are very similar to Tbet + ILCs1 producing IFN-γ but differ in their higher cytotoxic potential.…”

Section: Pregnancy and Inflammationmentioning

confidence: 99%

PlGF Immunological Impact during Pregnancy

Albonici

Benvenuto

Focaccetti

et al. 2020

IJMS

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During pregnancy, the mother’s immune system has to tolerate the persistence of paternal alloantigens without affecting the anti-infectious immune response. Consequently, several mechanisms aimed at preventing allograft rejection, occur during a pregnancy. In fact, the early stages of pregnancy are characterized by the correct balance between inflammation and immune tolerance, in which proinflammatory cytokines contribute to both the remodeling of tissues and to neo-angiogenesis, thus, favoring the correct embryo implantation. In addition to the creation of a microenvironment able to support both immunological privilege and angiogenesis, the trophoblast invades normal tissues by sharing the same behavior of invasive tumors. Next, the activation of an immunosuppressive phase, characterized by an increase in the number of regulatory T (Treg) cells prevents excessive inflammation and avoids fetal immuno-mediated rejection. When these changes do not occur or occur incompletely, early pregnancy failure follows. All these events are characterized by an increase in different growth factors and cytokines, among which one of the most important is the angiogenic growth factor, namely placental growth factor (PlGF). PlGF is initially isolated from the human placenta. It is upregulated during both pregnancy and inflammation. In this review, we summarize current knowledge on the immunomodulatory effects of PlGF during pregnancy, warranting that both innate and adaptive immune cells properly support the early events of implantation and placental development. Furthermore, we highlight how an alteration of the immune response, associated with PlGF imbalance, can induce a hypertensive state and lead to the pre-eclampsia (PE).

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Section: Pregnancy and Inflammationmentioning

confidence: 99%

PlGF Immunological Impact during Pregnancy

Albonici

Benvenuto

Focaccetti

et al. 2020

IJMS

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“…Development and maturation of NK cells: NK cell maturation is a continuous process that is initiated in the BM and is continued in peripheral tissues [30]. Mature NK cells reside in the BM and secondary lymphoid tissues such as lymph nodes [7].…”

Section: Development Maturation and Function Of Nk Cellsmentioning

confidence: 99%

“…Mature NK cells reside in the BM and secondary lymphoid tissues such as lymph nodes [7]. Thus, BM is not only the place for development, maturation, self-renewal and persistence of NK cells, but also it provides a line of defense against infections and tumors through utilizing the presence of NK cells [30]. The stages of development of NK cells include: NK progenitor cells, immature NK cells, and mature NK cells.…”

Section: Development Maturation and Function Of Nk Cellsmentioning

confidence: 99%

“…Maturation of NK cells starts in the BM then continues in peripheral tissues. Upon differentiation, mature NK cells migrate outside the BM and peculiar subsets of NK cells home back to or localize in the BM compartment to perform speci ic functions [30]. Human BM-resident NK cells have a unique transcriptional pro ile and resemble resident memory CD8 + T cells [18].…”

Section: Challenges Facing the Clinical Utilization Of Nk Cellsmentioning

confidence: 99%

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Natural killer cells in patients with hematologic malignancies, solid tumors and in recipients of hematopoietic stem cell transplantation

Ka¹,

Al-Jasser²,

Wk³

2019

J Stem Cell Ther Transplant

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“…One group of immune cells assumed to develop within the BM are natural killer (NK) cells [4], whereby NK cell development is also taking place at extramedullary sites [5]. NK cells are of great importance for the innate immune response as they are able to quickly and efficiently eliminate cells that have down-regulated human leukocyte antigen (HLA)-class I molecules on the cell surface, such as in damaged, malignant, and virus infected cells [6].…”

Section: Introductionmentioning

confidence: 99%

HCMV Infection in a Mesenchymal Stem Cell Niche: Differential Impact on the Development of NK Cells versus ILC3

Ising

Weinhold

Bennstein

et al. 2019

JCM

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Human cytomegalovirus (HCMV) is highly prevalent in most populations worldwide and has a major influence on shaping the human immune system. Natural killer (NK) cells are important antiviral effectors that adapt to HCMV infection by expansion of virus-specific effector/memory cells. The impact of HCMV infection on the development of NK cells and innate lymphoid cells (ILC) in general is less well understood. In this context, we have recently established a novel in vitro platform to study human NK cell development in a stem cell niche based on human bone marrow-derived mesenchymal stem cells (MSC). Here, the system was modified by infecting MSC with HCMV to study the influence of virus infection on NK/ILC development. We show that cord blood-derived hematopoietic progenitor cells are successfully differentiated into mature CD56 + CD94 + NKG2A + NK cells on HCMV-infected MSC with significant higher anti-viral cytokine production compared to NK cells developing on non-infected MSC. Furthermore, the generation of ILC3, characterized by expression of the signature transcription factor RAR-related orphan receptor gamma (RORγt) and the production of IL-22, was strongly impaired by HCMV infection. These observations are clinically relevant, given that ILC3 are associated with protection from graft-versus-host disease (GvHD) following stem cell transplantation and HCMV reactivation in turn is associated with increased incidence of GvHD.

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Bone Marrow NK Cells: Origin, Distinctive Features, and Requirements for Tissue Localization

Cited by 35 publications

References 63 publications

PlGF Immunological Impact during Pregnancy

PlGF Immunological Impact during Pregnancy

Natural killer cells in patients with hematologic malignancies, solid tumors and in recipients of hematopoietic stem cell transplantation

HCMV Infection in a Mesenchymal Stem Cell Niche: Differential Impact on the Development of NK Cells versus ILC3

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