Bone marrow spontaneous lesions in rodents from nonclinical 104-week carcinogenicity studies

Petterino, Claudio; Mukaratirwa, Samson; Bradley, Alys

doi:10.1016/j.toxlet.2015.09.008

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…Thymic lymphoma has also been reported, and all lymphopoietic tissues may be affected . Lymphomas may be characterized via immunohistochemistry as previously described in rats, and may be staged via bone marrow biopsy, similar to other species. In a clinical setting, ultrasound‐guided fine‐needle aspirations of thoracic masses may allow antemortem diagnosis of lymphomas in rats.…”

Section: Discussionmentioning

confidence: 94%

COMPARISON BETWEEN THORACIC RADIOGRAPHIC FINDINGS AND POSTMORTEM DIAGNOSIS OF THORACIC DISEASES IN DYSPNEIC COMPANION RATS (RATTUS NORVEGICUS)

Fouriez-Lablee

Vergneau‐Grosset

Kass

et al. 2016

Vet Radiology Ultrasound

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Companion rats are often presented to veterinarians for respiratory difficulties. Dyspnea in rats is most commonly due to infectious pneumonia, and thoracic neoplasia can go undiagnosed ante mortem due to a mistaken interpretation of pneumonia. In domestic carnivores, pulmonary nodular patterns have been shown to correlate with lung neoplastic diseases and infectious diseases. The main objective of this retrospective case series study was to determine whether certain radiographic criteria could be correlated with the presence of thoracic infectious disease and neoplastic disease in companion rats. A secondary objective was to determine whether the patient's sex and age were different between rats diagnosed with infectious versus neoplastic disease. Medical records and thoracic radiographs of dyspneic companion rats presented to the University of California at Davis, William R. Pritchard Veterinary Medical Teaching Hospital during the time period from January 2000 to December 2014 were reviewed. Rats with postmortem confirmation of thoracic lesions were included in the study. Thoracic radiographs were evaluated for positioning, lesion distribution, lung lobe involved, pulmonary pattern, mediastinal and pleural lesions by three observers blinded to diagnosis. Thirty rats were included in the study, including 23 rats with an infectious disease and seven with neoplasia. Mediastinal lesions were significantly more prevalent in the group diagnosed with thoracic neoplasia (P = 0.031), in particular cranially (P = 0.048). Although there was an overlap between the two groups, findings indicated that the presence of cranial mediastinal lesions may be helpful for differentiating neoplastic from infectious disease in rats.

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Section: Discussionmentioning

confidence: 94%