Bone marrow stem cell protection from chemotherapy by low–molecular-weight compounds

In vitro assessment of bone marrow endothelial colonies (CFU-En) in non-Hodgkin's lymphoma patients undergoing peripheral blood stem cell transplantation

“…34 On the other hand, other reports have shown that the existence of circulating BM endothelial progenitor cells can restore blood flow to ischemic animals leading to the concept of 'therapeutic adult vasculogenesis' that may explain the recruitment of ECs to various target organs such as BM, where they might contribute to the in situ neo-vascularization. [33][34][35][36][37][38][39][40] This phenomenon may sustain a physiological angiogenesis process, which is probably essential for tissue repair, remodeling, and regeneration and these are in line with our results, since the number of CFU-En from patients in remission phase positively correlated with the frequency of BM CFU-GM colonies, possibly suggesting a parallel process of bone marrow reconstitution. [33][34][35][36][37][38][39][40] In conclusion, Endothelial colonies in non-Hodgkin's lymphomaour in vitro data have shown that NHL patients in remission state have higher numbers of CFU-En than that of newly diagnosed subjects, thus providing a rationale for further investigating the effects of different cytostatic drugs on endothelial cells growth and function.…”

“…[33][34][35][36][37][38][39][40] This phenomenon may sustain a physiological angiogenesis process, which is probably essential for tissue repair, remodeling, and regeneration and these are in line with our results, since the number of CFU-En from patients in remission phase positively correlated with the frequency of BM CFU-GM colonies, possibly suggesting a parallel process of bone marrow reconstitution. [33][34][35][36][37][38][39][40] In conclusion, Endothelial colonies in non-Hodgkin's lymphomaour in vitro data have shown that NHL patients in remission state have higher numbers of CFU-En than that of newly diagnosed subjects, thus providing a rationale for further investigating the effects of different cytostatic drugs on endothelial cells growth and function. However, based on results on BM hematopoietic colony assays and on previously published papers the data here presented seem to suggest that human bone marrow endothelial cells could also be involved in mechanisms, which are different from tumor angiogenesis, such as hematopoietic cell preservation and physiological repair after chemotherapy.…”

“…29,30 Furthermore, it must be said that some of these patients received radiotherapy, which can induce an upregulation of the E-9 protein (CD105) in human vascular endothelial cells. 31 Human bone marrow endothelial cells present in remission phase may also have the effect of protecting and maintaining the hematopoietic stem cell compartment from extensive differentiation through the production of differentiation inhibitors such as thymosin b4 and AcSDKP 32,33 that has been shown to induce angiogenesis in vitro and in vivo. 34 On the other hand, other reports have shown that the existence of circulating BM endothelial progenitor cells can restore blood flow to ischemic animals leading to the concept of 'therapeutic adult vasculogenesis' that may explain the recruitment of ECs to various target organs such as BM, where they might contribute to the in situ neo-vascularization.…”

Inhibition of angiotensin I–converting enzyme induces radioprotection by preserving murine hematopoietic short-term reconstituting cells

“…[1][2][3][4][5][6] In this way, they may prevent DNA breakage during the S phase and subsequent apoptosis. One of these negative regulators, the tetrapeptide AcSDKP (acetyl-N-Ser-Asp-Lys-Pro), has been evaluated in preclinical studies.…”

An in vivo insight to the toxicological profile of various organotellurides

“…While , 2005), protection of bone marrow stem cells during chemotherapy (Guest and Uetrecht, 2001) and restoration of dopaminergic neurons in a Parkinson's disease model (Sredni et al, 2007). Despite their interesting physiological and beneficial properties, organochalcogens can be toxic.…”