Bone Marrow Stroma and the Leukemic Microenvironment

Slayton, William B.; Hu, Zhongbo

doi:10.1002/9780470669891.ch6

Cited by 1 publication

(1 citation statement)

References 182 publications

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“…Evidence suggests that macrophages may account for the major part of the host leukocyte infiltrate in the majority of human malignant tumors [7,21]. Several investigators had counted the TAM in cancer surgical specimen under microscopy by immunohistochemical staining and reported that the percentage of TAM in human malignancies is between 10 and 65% [22,23]. Tissues that contain a high proportion (>50%) of immature fibroblasts correlate with decreased TAMs, epithelial-mesenchymal transition, and poor prognosis [24].…”

Section: Discussionmentioning

confidence: 99%

Tumor-Associated T-Lymphocytes and Macrophages are Decreased in Endometrioid Endometrial Carcinoma with MELF-Pattern Stromal Changes

Зиновкин

Pranjol

Bilsky

et al. 2018

Cancer Microenvironment

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Microcystic, elongated, fragmented (MELF)-pattern is an unusual morphology of myometrial invasive front in endometrioid endometrial carcinoma (EA). The aim of the study was to investigate potential correlation between MELF-pattern and peritumoral inflammatory immune response. A total of 96 out of 368 patients were included in this study. CD3, CD20, CD57. CD68 and S100 markers were used for the detection of tumor-associated T-lymphocytes (TAT), tumor-associated B-lymphocytes (TAB), tumor-associated NK-lymphocytes (NK), tumor-associated macrophages and dendritic cells respectively. Mann-Whitney tests, receiver operating characteristic (ROC) curve analysis, and Spearman correlation were used as methods for statistical analyses. Odds ratio with 95% confidence interval (95% CI) was determined with the use of a logistic regression model. A p < 0.05 was considered statistically significant. Our results suggested that the number of CD3 and CD68 cells were significantly lower (p < 0.001) in cases of endometrioid carcinoma with MELF-pattern. A significant correlation between the presence of MELF-pattern and decrease of CD3 positive T-lymphocytes (r = 0.691; p < 0.001) was also observed. Additionally, we found an inverse correlation between the presence of MELF-pattern and TAM (r = 0.568; p = 0.001). Therefore, our data suggest that MELF-pattern may be associated with EA stroma fibrosis that contains immune cells infiltration and demonstrated a decrease in the number of TAT and TAM cells. This may indicate the poor clinical prognosis of this disease.

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