Bone marrow transplantation for acquired aplastic anemia: What's new

Bacigalupo, Andrea; Benintende, Giulia

doi:10.1016/j.beha.2021.101284

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…As previously reported, the hIDPSCs employed in this study are considered as MSC-like cells, which expresses the typical MSC markers proposed by the International Society for Cellular and Gene Therapy (ISCGT) [ 1 ], being positive for CD105, CD73, CD90, and CD44 and negative for CD45, CD34, CD14, and HLA class II [ 2 , 3 , 4 ]. However, unlike other typical MSCs, including stem cells from exfoliated deciduous teeth (SHED), the hIDPSCs express and secrete high levels of the neuronal marker nestin, as previously demonstrated by Kerkis and Caplan [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…Although the pathophysiology of acquired AA remains unknown, cumulative evidence has supported the understanding that the immune-mediated destruction of HSPCs plays a central role in the pathogenesis of acquired AA [ 2 ]. In this sense, several environmental factors, including drugs, chemicals, radiation, and viruses have already been identified as responsible for dysregulating CD8+ cytotoxic T cells and CD4+ T cells, including T helper type 1 (Th1) and 2 (Th2), regulatory T (Treg) and Th17 cells, and natural killer (NK), leading to the abnormal production of cytokines, such as tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β, which induce apoptosis of HSPCs [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Potential of Human Immature Dental Pulp Stem Cells Observed in Mouse Model for Acquired Aplastic Anemia

Gonzaga

Wenceslau²,

Vieira

et al. 2022

Cells

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Aplastic anemia (AA) is a rare and serious disorder of hematopoietic stem cells (HSCs) that results in the loss of blood cells due to the failure of the bone marrow (BM). Although BM transplantation is used to treat AA, its use is limited by donor availability. In this sense, mesenchymal stem cells (MSCs) can offer a novel therapeutic approach for AA. This is because the MSCs contribute to the hematopoietic niche organization through their repopulating. In our study, we used the human immature dental pulp stem cell (hIDPSC), an MSC-like cell, to explore an alternative therapeutic approach for AA. For this, isogenic C57BL/6 mice were exposed to total body irradiation (TBI) to induce the AA. After 48 h of TBI, the mice were intraperitoneally treated with hIDPSC. The immunohistochemistry analyses confirmed that the hIDPSCs migrated and grafted in the mouse bone marrow (BM) and spleen, providing rapid support to hematopoiesis recovery compared to the group exposed to radiation, but not to those treated with the cells as well as the hematological parameters. Six months after the last hIDPSC transplantation, the BM showed long-term stable hematopoiesis. Our data highlight the therapeutic plasticity and hematoprotective role of hIDPSC for AA and potentially for other hematopoietic failures.

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