Bone marrow transplantation improves hepatic fibrosis inAbcb4^−/−mice via Th1 response and matrix metalloproteinase activity

Abstract

These results show that BM-Tx causes an antifibrotic Th1 response combined with transient inflammatory effects and subsequently upregulated MMP activity. Antifibrotic Th polarisation and prolonged proteolytic activity, especially of MMP-9, might be responsible for long-term amelioration of hepatic fibrosis.

The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction

“…In contrast, we found a significantly more pronounced increase in MMP-9 levels from baseline to 2-3 weeks in the mBMC group compared to controls. In accordance with our findings Roderfelt et al demonstrated a transient inflammatory response and upregulation of MMP-9 activity after bone marrow transplantation in Abcb 4 −/− (hepatic fibrosis) mice [26]. We have previously shown that MMP-9 levels are reduced 1 day after AMI [27].…”

Curative effect of hepatic portal venous administration of autologous bone marrow in AIDS patients with decompensated liver cirrhosis

“…Thus, it is considered feasible to directly transfuse fresh bone marrow (bone marrow transplantation (BMT)) to achieve therapeutic goals. 6, 7 To assess the efficacy and safety of transfusing autologous bone marrow in AIDS patients accompanied by advanced liver cirrhosis, we conducted a single-arm trial. The protocol was approved by the Ethics Committee of the Public Health Clinical Center Affiliated with Fudan University.…”

Bone Marrow Stem Cell Therapy for Liver Disease

“…The anti-fibrotic effect of BM-derived stem cells has been reported to be accompanied by significant upregulation of matrix metalloproteinases in the injured liver, predominantly MMP-9 but also MMP-2 and -13 [39,44,50]. This has been observed following infusions of both HSC and MSC, and reported to persist for up to 20 weeks following cell infusion [50].…”

“…This has been observed following infusions of both HSC and MSC, and reported to persist for up to 20 weeks following cell infusion [50]. Although increased MMP expression may mediate the anti-fibrotic effect, the cellular source remains unclear.…”