Bone Marrow Transplantation in Five Children With Sickle Cell Anaemia

Vermylen, Christiane; Robles, E Fernandez; Ninane, J.; Cornu, Guy

doi:10.1016/s0140-6736(88)92239-8

Cited by 112 publications

(41 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Her leukemia was cured and she was converted to sickle cell trait [132]. In the following decade, several pilot studies of bone marrow transplantation for the treatment of young patients with symptomatic SCD demonstrated eradication of the underlying disease with low transplantation-related mortality [133][134][135][136]. In 1996, Walters et al reported the results of HLAidentical allogeneic transplantation in 22 individuals with SCD (all <16 years old), of which 20 survived and 16 had stable engraftment of donor cells [137].…”

Section: Hematopoietic Stem Cell Transplantation In Scdmentioning

confidence: 99%

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

2015

View full text Add to dashboard Cite

Over the past 40 years, public health measures such as universal newborn screening, penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive decline in sickle cell disease (SCD)-related childhood mortality and SCD-related morbidity in high-income countries. We remain cautiously optimistic that the next 40 years will be focused on meeting current challenges in SCD by addressing chronic complications of SCD to reduce mortality and improve quality of life in a growing population of adults with SCD in high-income countries, while simultaneously decreasing the disparity of medical care between high and low-income countries.

show abstract

Section: Hematopoietic Stem Cell Transplantation In Scdmentioning

confidence: 99%

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

2015

View full text Add to dashboard Cite

show abstract

“…[16][17][18][19][20][21][22][23][24][25] The French transplantation experience in this setting began in 1988, 17,20,22,23 following grafting in a patient with SCD and leukemia in the United States 25 and in 5 patients with SCD in Belgium. 16 Here, we report the results of familial allogeneic HSCT after myeloablative conditioning in 87 consecutive young patients with severe SCD.…”

Section: Introductionmentioning

confidence: 99%

Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease

Bernaudin

Socié

Kuentz

et al. 2007

Blood

449

440

View full text Add to dashboard Cite

“…However, as transplant care improved, a few years later, a small group of patients in Belgium was successfully transplanted explicitly for SCD. 2 This work helped lead in the 1990s to an international trial of HLA-identical sibling HSCT for SCD. 3 This study was limited to patients with severe SCD who had suffered certain complications like a stroke ( Table 1).…”

Section: Introductionmentioning

confidence: 99%

The ethics of a proposed study of hematopoietic stem cell transplant for children with “less severe” sickle cell disease

Nickel

Hendrickson

Haight

2014

Blood

View full text Add to dashboard Cite

Hematopoietic stem cell transplant (HSCT) is the only cure for sickle cell disease (SCD). HSCT using an HLA-identical sibling donor is currently an acceptable treatment option for children with severe SCD, with expected HSCT survival >95% and event-free survival >85%. HSCT for children with less severe SCD (children who have not yet suffered overt disease complications or only had mild problems) is controversial. It is important to consider the ethical issues of a proposed study comparing HLA-identical sibling HSCT to best supportive care for children with less severe SCD. In evaluating the principles of nonmaleficence, respect for individual autonomy, and justice, we conclude that a study of HLA-identical sibling HSCT for all children with SCD, particularly hemoglobin SS and Sβ0-thalassemia disease, is ethically sound. Future work should explore the implementation of a large trial to help determine whether HSCT is a beneficial treatment of children with less severe SCD.

show abstract

Bone Marrow Transplantation in Five Children With Sickle Cell Anaemia

Cited by 112 publications

References 7 publications

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease

The ethics of a proposed study of hematopoietic stem cell transplant for children with “less severe” sickle cell disease

Contact Info

Product

Resources

About