Bone matrix quality in a developing high-fat diet mouse model is altered by RAGE deletion

Stephen, Samuel J.; Bailey, Stacyann; D'Erminio, Danielle N.; Krishnamoorthy, Divya; Iatridis, James C.; Vashishth, Deepak

doi:10.1016/j.bone.2022.116470

Cited by 6 publications

(1 citation statement)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29 Some of these observations may stem from what is measured as well as how, plus observations that dynapenic abdominal obesity, denoting weak muscles, is related to a heightened risk for falling among older adults, 30 as is obesity assessed by body mass index and waist circumference in older Chinese cases who might sustain falls. 31 Importantly, if a fracture injury occurs, the presence of obesity tends to hamper repair 32 and may disrupt bone morphology via inflammatory and other mechanisms 33,34 as identified in a laboratory study by Stephen et al, 35 and may be especially accentuated in those categorized as being morbidly obese. 36 As concluded by Crivelli et al, 37 when these findings are viewed concurrently, they tend to suggest that both visceral and subcutaneous fat may be detrimental for bone health in pre-and postmenopausal women, and that severe obesity may increase the risk of vertebral fractures, even in young women.…”

Section: Resultsmentioning

confidence: 99%

Obesity and bone health: key 2020–2022 highlights and implications

Marks¹

2022

AOWMC

View full text Add to dashboard Cite

Sound bone health is crucial for life affirming activities, but is bone physiology impacted in the face of excess body weight? Since fractures and osteoporosis are on the rise, is obesity a risk factor for, as well as a possible negative albeit remediable correlate of bone health in the older adult? To examine this premise the PUBMED and GOOGLE SCHOLAR data bases were sourced for relevant data published between January 1 2020 and November 1 2022 in an effort to capture post COVID-19 possible research observations on the topic. These data bases show while a pervasive idea has been that obesity may be beneficial in some respects to bone mineral density attributes and impart fracture protection, several current publications tend to portray a negative impact of obesity on bone health via multiple proposed mechanisms. However, the research points to a strong need for continued research as well as clinical vigilance of vulnerable individuals both young and old in a period where obesity rates in all age groups appear to be on the rise, along with cases of bone fragility and osteoarthritis that can both foster high morbidity and mortality rates and possibly more challenging weight issues in the face of painful fractures or joint derangement.

show abstract