Bone Maturation and Bone Mineralization in Precocious Puberty: Relation to Estrogen Receptor Gene Polymorphisms.

Effect of Testosterone on Bone Mineral Gain: Observations of Male Patients with Growth Hormone Deficiency and Normal Gonadotropin Secretion

“…Growth hormone (GH) and sex steroids are the major determinants of bone mineral density (BMD). Over the past several years, the dominant role of androgens in male bone physiology has been increasingly questioned as data have emerged suggesting an important role for estrogens in male skeletal development and homeostasis, but some reports elucidate the effects of androgen on skeletal development and maintenance ( 1 , 2 , 3 , 4 ). We consider that more clinical evidence on the effects of androgens on actual bone growth is needed to clarify their possible physiological roles in the regulation of bone formation and mineralization ( 5 ).…”