2016
DOI: 10.1007/s00223-016-0192-9
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Bone Metabolism and the c.-223C > T Polymorphism in the 5′UTR Region of the Osteoprotegerin Gene in Patients with Inflammatory Bowel Disease

Abstract: Osteoporosis is more frequent in inflammatory bowel disease (IBD) patients. A reduction in bone mineral mass in these individuals is caused not only by inflammatory processes in the bowel, because osteoporosis occurs already in very young IBD patients and in newly diagnosed individuals who have not yet undergone any pharmacological treatment. One of individual determinants of the bone turnover parameters is osteoprotegerin (OPG) encoded by the TNFRSF11B gene. The c.-223C > T polymorphism in this gene has been … Show more

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Cited by 14 publications
(13 citation statements)
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“…Hence, it is possible that certain kinds of biases may not have been found. Some studies have shown that inflammatory bowel disease patients have a genetic predisposition to osteoporosis [45], such as variations in the IL‐6 and IL‐1 genes, which may explain the unknown bias in the detection of BMD in ulcerative colitis patients [46,47]. Second, steroids have been shown to contribute to low BMD in ulcerative colitis patients, and various patients in these studies had taken glucocorticoids as a normal treatment for ulcerative colitis before the detection of BMD, and the doses received by these patients varied.…”
Section: Discussionmentioning
confidence: 99%
“…Hence, it is possible that certain kinds of biases may not have been found. Some studies have shown that inflammatory bowel disease patients have a genetic predisposition to osteoporosis [45], such as variations in the IL‐6 and IL‐1 genes, which may explain the unknown bias in the detection of BMD in ulcerative colitis patients [46,47]. Second, steroids have been shown to contribute to low BMD in ulcerative colitis patients, and various patients in these studies had taken glucocorticoids as a normal treatment for ulcerative colitis before the detection of BMD, and the doses received by these patients varied.…”
Section: Discussionmentioning
confidence: 99%
“…Todhunter et al [10] also failed to find a correlation between polymorphisms in NOD2/CARD15 and osteoporosis. A recent study has also found polymorphism in TNF superfamily11B gene, which may be associated with bone loss in Crohn's disease (CD) [11]. Very few studies have tested clinical and demographic risk factors associated with bone density in Israeli IBD patients, and, to our knowledge, no study has tested a correlation with common genetic mutations.…”
mentioning
confidence: 94%
“…Krela-Kaźmierczak I. et al showed that low OPG levels may be associated with osteoporosis in UC. Nevertheless, in CD patients increased RANKL levels were observed [ 20 , 21 ]. Interleukin 6 can modulate BMD via the OPG/sRANKL system in the femoral neck, which can cause a loss of bone, particularly in the course of CD.…”
Section: Introductionmentioning
confidence: 99%