Bone metastases as a cause of hypocalcaemia

Talapatra, Indrajit; Tymms, D J

doi:10.1111/j.1368-5031.2005.00627.x

Cited by 1 publication

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To the best of our knowledge, this is the first described case of paraneoplastic hypocalcemia-induced heart failure with normal PTH values ( 2 , 16 ). Frequently reported in advanced prostate cancer, hypocalcemia is suggested to be a consequence of osteoblastic metastases inducing increased calcium uptake in the bones, which may result in secondary hyperparathyroidism ( 12 , 17 ). This is due to calcium-sensing receptors in parathyroid cells that detect very small changes in the plasma calcium-ion concentration, triggering the release of PTH when serum calcium is decreased ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic hypocalcemia-induced heart failure in advanced breast cancer: A case report and literature review

Farolfi¹,

Ferrario²,

Aquilina³

et al. 2015

Oncology Letters

View full text Add to dashboard Cite

Hypocalcemia is an uncommon clinical symptom of patients with malignant tumors, and a number of factors may be involved in its development. The present study describes the case of a 67-year-old Caucasian female, presenting with severe refractory hypocalcemia and heart failure. The patient was subsequently diagnosed with breast cancer and bone metastases. The paraneoplastic origin of the syndrome was confirmed by its complete resolution once the tumor responded to specific antineoplastic treatments, comprising weekly paclitaxel and aromatase inhibitor administration. The present case report suggested the need for greater awareness of the possibility of paraneoplastic hypocalcemia in breast cancer patients, and suggested that this condition may also contribute to the occurrence of heart failure. The mechanisms potentially responsible for this event were discussed and a brief review of the literature presented.

show abstract

Section: Discussionmentioning

confidence: 99%