Bone metastases as the initial presentation of carcinoma of gall bladder: a rarity

Jain, Gaurav; Samaiya, Atul; Mohindra, Namita; Patel, Kailash

doi:10.1007/s12262-009-0008-5

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…[3] Metastases frequently involve liver (76-86%) and regional lymph nodes (60%). [4] Distant metastasis to virtually all organs is possible[345] and has been reported but distant metastasis to bone is rare. [456] The reason may lie in the rapidly growing nature of this malignancy that causes the demise of the patient early due to local infiltration, leaving little time for the development of bony metastasis.…”

Section: Discussionmentioning

confidence: 99%

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Gall bladder carcinoma presenting with spinal metastasis: A rare phenomenon

Joshi¹,

Joshi²,

Chadha³

et al. 2013

Indian J Palliat Care

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Skeletal metastasis as a primary presentation of gall bladder carcinoma is rare. A 50-year-old lady presented with neck pain and weakness in her right upper limb of 3 months duration. Clinical and imaging work-up suggested locally advanced gall bladder carcinoma with metastasis to cervical vertebra and sternum. Only one case till date has been reported where the patient presented with neurological symptoms due to pathological fracture secondary to metastasis from an occult gall bladder carcinoma. Although rare, an occult gall bladder cancer may present with neurological symptoms due to pathological fracture of spine secondary to metastasis. We present a brief review of literature of patients who presented with skeletal metastases in clinically silent gall bladder malignancy. Palliative care issues in advanced gall bladder carcinoma have also been discussed.

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Section: Discussionmentioning

confidence: 99%

“…Following an extensive review of the published English literature, we could retrieve only six such cases [Table 1]. [345789] Our patient presented with neurological deficit secondary to spinal metastasis. Only one such case has been reported so far.…”

Section: Discussionmentioning

confidence: 99%

Gall bladder carcinoma presenting with spinal metastasis: A rare phenomenon

Joshi¹,

Joshi²,

Chadha³

et al. 2013

Indian J Palliat Care

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“…To the best of our knowledge, less than 10 cases have been reported in literature with gall bladder malignancy, clinically presenting with clinical features of skeletal secondaries. The reported sites of skeletal secondaries were femur, clavicle, humerus, calvaria, and lumbar vertebrae [31][32][33][34]. The recognition of skeletal metastasis is clinically important to tailor the appropriate palliative care, even when the bony disease is clinically silent.…”

Section: Discussionmentioning

confidence: 99%

Bony Secondaries and Dissemination in Advance Carcinoma Gallbladder: A Longitudinal Study

Dd¹

2018

CRIJ

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Context: Metastasis in carcinoma gall bladder is uncommon and occurs late in the course of the disease. Of all the distant sites that can be involved, the skeletal system is the least common site. We hereby present a prospective longitudinal study depicting the incidence, type, predisposing site and time of presentation of skeletal metastasis in carcinoma gallbladder. Aims: The present study provides new and important information regarding skeletal metastases which may be more common with the introduction of laparoscopic cholecystectomy and should be excluded before radical resection is contemplated.

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“…But distant metastases to the adrenal, kidney, brain, skin, breast, thyroid, heart and orbit which have been explained in the literature. 2–4 …”

Section: Discussionmentioning

confidence: 99%

“…It spreads mainly to the liver and regional lymph nodes along the cystic duct, common hepatic duct and common bile duct and to pre and para-aortic lymph nodes but distant metastasis has also been explained in the literature. 2,3 Here in we report a case of carcinoma of the gallbladder metastasizing to the heart and presenting with features of malignant pericardial effusion. This is 7th such case to report cardiac metastasis from gallbladder carcinoma.…”

Section: Introductionmentioning

confidence: 93%

Cardiac metastasis from gallbladder carcinoma

Gunjiganvi

Singh

Harsha

et al. 2013

International Journal of Surgery Case Reports

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INTRODUCTIONPrimary gallbladder carcinoma is a rare aggressive neoplasm of elderly with poor prognosis. The tumour is often unresectable at the time of diagnosis. Metastasis to heart is rare and only 6 cases have been reported in the indexed literature. We herein report a case of gallbladder carcinoma metastasizing to heart.PRESENTATION OF CASEA 54 year old female presented with dyspnoea and chest pain with past history of radical cholecystectomy and palliative chemotherapy for adenocarcinoma of gallbladder. Chest X-ray showed cardiomegaly and 2-D ECHO revealed features of tumour deposits on the surface of myocardium and malignant pericardial effusion. Mini-thoracotomy and pericardial window procedure was done to relieve distressing symptoms and biopsy of pericardial tissue revealed metastatic adenocarcinoma. In spite of intensive care, patient succumbed to disease in the post-operative period.DISCUSSIONPrimary adenocarcinoma of gallbladder is the most common malignancy of biliary tract and fifth most common malignancy of gastro-intestinal system with dismal prognosis. It most commonly spreads to liver and regional lymph nodes, very rarely distant metastasis occurs to kidney, adrenal, thyroid and bones as reported in the literature. Metastasis to heart presents with symptoms of cardiac failure due to pericardial effusion. Even with intensive care patients will invariably succumb to the disease.CONCLUSIONMetastatic spread to heart from carcinoma of gallbladder is very rare. Should a patient be suspected of or an operated case of gallbladder carcinoma present with symptoms of congestive heart failure and massive pericardial effusion, cardiac metastasis should be considered.

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Bone metastases as the initial presentation of carcinoma of gall bladder: a rarity

Cited by 6 publications

References 10 publications

Gall bladder carcinoma presenting with spinal metastasis: A rare phenomenon

Gall bladder carcinoma presenting with spinal metastasis: A rare phenomenon

Bony Secondaries and Dissemination in Advance Carcinoma Gallbladder: A Longitudinal Study

Cardiac metastasis from gallbladder carcinoma

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