Bone metastases from breast cancer: associations between morphologic CT patterns and glycolytic activity on PET and bone scintigraphy as well as explorative search for influential factors

Sugihara, Tsutomu; Koizumi, Mitsuru; Koyama, Masamichi; Terauchi, Takashi; Gomi, Naoya; Ito, Yoshiaki; Hatake, Kiyohiko; Sata, Naohiro

doi:10.1007/s12149-017-1202-3

Cited by 20 publications

(66 citation statements)

References 17 publications

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“…In a retrospective Japanese study of 88 breast cancer patients with bone metastasis, they found higher lesion-based sensitivity (94%) for FDG-PET/CT than for CT and BS (77% and 89%, respectively), which were in line with the results of our study. However, they found a relatively lower detection of osteosclerotic lesions for FDG-PET/CT than other lesion types [ 13 ], which was not confirmed by our study. Additional to the results of previous studies regarding the superiority of FDG-PET/CT in detection of bone metastases compared to BS [ 11 , 12 , 15 ], our study showed that LDCT and BS combined could provide sensitivity equal to that of FDG-PET/CT in detection of skeletal metastases.…”

Section: Discussioncontrasting

confidence: 95%

Diagnosis of bone metastases in breast cancer: Lesion-based sensitivity of dual-time-point FDG-PET/CT compared to low-dose CT and bone scintigraphy

et al. 2021

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We compared lesion-based sensitivity of dual-time-point FDG-PET/CT, bone scintigraphy (BS), and low-dose CT (LDCT) for detection of various types of bone metastases in patients with metastatic breast cancer. Prospectively, we included 18 patients with recurrent breast cancer who underwent dual-time-point FDG-PET/CT with LDCT and BS within a median time interval of three days. A total of 488 bone lesions were detected on any of the modalities and were categorized by the LDCT into osteolytic, osteosclerotic, mixed morphologic, and CT-negative lesions. Lesion-based sensitivity was 98.2% (95.4–99.3) and 98.8% (96.8–99.5) for early and delayed FDG-PET/CT, respectively, compared with 79.9% (51.1–93.8) for LDCT, 76.0% (36.3–94.6) for BS, and 98.6% (95.4–99.6) for the combined BS+LDCT. BS detected only 51.2% of osteolytic lesions which was significantly lower than other metastatic types. SUVs were significantly higher for all lesion types on delayed scans than on early scans (P<0.0001). Osteolytic and mixed-type lesions had higher SUVs than osteosclerotic and CT-negative metastases at both time-points. FDG-PET/CT had significantly higher lesion-based sensitivity than LDCT and BS, while a combination of the two yielded sensitivity comparable to that of FDG-PET/CT. Therefore, FDG-PET/CT could be considered as a sensitive one-stop-shop in case of clinical suspicion of bone metastases in breast cancer patients.

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Section: Discussioncontrasting

confidence: 95%

Diagnosis of bone metastases in breast cancer: Lesion-based sensitivity of dual-time-point FDG-PET/CT compared to low-dose CT and bone scintigraphy

et al. 2021

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“…Our study revealed weak sensitivity for PET just 16.7% while CT showed 100% sensitivity. A study made by Sugihara et al [10] found the sensitivity of PET was 69% (11/16). This difference can be explained by the smaller sample size in our study for the osteoblastic metastases.…”

Section: Discussionmentioning

confidence: 97%

“…In bony lytic lesions, it is reported that CT has lower sensitivity than PET. A study conducted by Sugihara et al [10] revealed sensitivities of CT and PET were 77.9% and 94% respectively. Our study revealed similar sensitivities where it was for CT 89% and for PET it was 100%.…”

Section: Discussionmentioning

confidence: 97%

The added value of hybrid 18F-FDG PET/CT over CT in the detection of breast cancer metastatic deposits

Abd-Elkader

Hassan

Omar

et al. 2020

Egypt J Radiol Nucl Med

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Background: Breast cancer is a major health problem resulting in high morbidity and mortality. Early diagnosis of primary and secondary lesions is crucial to optimize treatment options. Our study aimed to investigate the role of PET-CT and CT alone in detecting metastatic lesions in breast cancer patients. Result: This retrospective study showed better PET diagnostic performance in the detection of lymph nodal and lytic bony metastatic deposits with more accurate detection of the malignant nature of hepatic focal lesions and detection of activity in sclerotic bony lesions, compared with CT alone, while CT had a higher value in the localization of lesions. Hybrid PET/CT showed optimal diagnostic performance than each modality separately. Conclusion: The combination of CT and PET was a powerful diagnostic tool that is more accurate than CT alone in the detection of distant metastases.

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“…Aquiduo PET/CT scanner has the following technical characteristics: detector material, Lu 2 SiO 5 (Ce) (LSO); crystal size, 4.0 × 4.0 × 20 mm 3 ; detector ring diameter, 830 mm; transaxial field of view (FOV), 585 mm; axial FOV, 162 mm, coincidence window, 4.5 ns; energy window, 425–650 keV; maximum ring difference, 27; random correction, delayed; scatter correction, single scatter simulation. Emission data were acquired for 2–3 min per bed position 17 . The PET images were reconstructed using an iterative algorithm (the combination of Fourier rebinning and the ordered subsets expectation–maximization [FORE + 2D-OSEM]; 4 iterations, 14 subsets) with an 8-mm Gaussian filter, a 128 × 128 matrix (3.9 mm/pixel) and 81 slices (2 mm/slice).…”

Section: Methodsmentioning

confidence: 99%

Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis

Suga

Nishii²,

Miwa

et al. 2021

Sci Rep

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The differentiation of non-small cell lung cancer (NSCLC) and radiation pneumonitis (RP) is critically essential for selecting optimal clinical therapeutic strategies to manage post carbon-ion radiotherapy (CIRT) in patients with NSCLC. The aim of this study was to assess the ability of 18F-FDG PET/CT metabolic parameters and its textural image features to differentiate NSCLC from RP after CIRT to develop a differential diagnosis of malignancy and benign lesion. We retrospectively analyzed 18F-FDG PET/CT image data from 32 patients with histopathologically proven NSCLC who were scheduled to undergo CIRT and 31 patients diagnosed with RP after CIRT. The SUV parameters, metabolic tumor volume (MTV), total lesion glycolysis (TLG) as well as fifty-six texture parameters derived from seven matrices were determined using PETSTAT image-analysis software. Data were statistically compared between NSCLC and RP using Wilcoxon rank-sum tests. Diagnostic accuracy was assessed using receiver operating characteristics (ROC) curves. Several texture parameters significantly differed between NSCLC and RP (p < 0.05). The parameters that were high in areas under the ROC curves (AUC) were as follows: SUVmax, 0.64; GLRLM run percentage, 0.83 and NGTDM coarseness, 0.82. Diagnostic accuracy was improved using GLRLM run percentage or NGTDM coarseness compared with SUVmax (p < 0.01). The texture parameters of 18F-FDG uptake yielded excellent outcomes for differentiating NSCLC from radiation pneumonitis after CIRT, which outperformed SUV-based evaluation. In particular, GLRLM run percentage and NGTDM coarseness of 18F-FDG PET/CT images would be appropriate parameters that can offer high diagnostic accuracy.

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Bone metastases from breast cancer: associations between morphologic CT patterns and glycolytic activity on PET and bone scintigraphy as well as explorative search for influential factors

Cited by 20 publications

References 17 publications

Diagnosis of bone metastases in breast cancer: Lesion-based sensitivity of dual-time-point FDG-PET/CT compared to low-dose CT and bone scintigraphy

Diagnosis of bone metastases in breast cancer: Lesion-based sensitivity of dual-time-point FDG-PET/CT compared to low-dose CT and bone scintigraphy

The added value of hybrid 18F-FDG PET/CT over CT in the detection of breast cancer metastatic deposits

Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis

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