Bone Metastases of Hepatocellular Carcinoma: Appearance on MRI Using a Standard Abdominal Protocol

Velloni, Fernanda; Ramalho, Miguel; AlObaidy, Mamdoh; Matos, António P.; Altun, Ersan; Semelka, Richard C.

doi:10.2214/ajr.15.15502

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…12 Skeletal involvement from HCC is less common (25% of all extrahepatic metastases). 13 Most HCC-associated bone metastases are in the thoracic (70%) and lumbar spine (20%), which are expansile and osteolytic and often associated with extensive soft tissue masses. 14 Various case reports of HCC presenting with neurological symptoms have been described, which are secondary to compressive symptoms caused by the soft tissue component of the osteolytic bony metastasis.…”

Section: Discussionmentioning

confidence: 99%

Case Report with a Review of Literature: Pancoast Syndrome—A Rare Presentation of Metastatic Hepatocellular Carcinoma

Singuluri,

Ganesan,

Srinivas

et al. 2023

Indian J Med Paediatr Oncol

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Superior sulcus tumors, also known as Pancoast tumors, present in a distinctive way with Horner's syndrome (ptosis, miosis, and anhidrosis), hand weakness brought on by the atrophy of the intrinsic hand muscles, and excruciating pain along the medial aspect of the arm. (1) Primary lung cancers constitute a majority of Pancoast tumors, but Pancoast syndrome can be multifactorial. (2) Here, we present a case of 62-year-old male who presented with right shoulder pain and weakness for 2 months. Clinically, he had a supraclavicular mass with atrophy of the intrinsic muscles of the hand and sensory-motor weakness. Computed tomography showed a mass lesion in the supraclavicular fossa with the erosion of the T1 vertebra and first rib, mimicking carcinoma right upper lobe. However, the biopsy from the mass was suggestive of metastasis from hepatocellular carcinoma (HCC). Our case report identifies HCC as a rare differential for Pancoast syndrome and highlights the unique metastatic presentation.

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Section: Discussionmentioning

confidence: 99%

Case Report with a Review of Literature: Pancoast Syndrome—A Rare Presentation of Metastatic Hepatocellular Carcinoma

Singuluri,

Ganesan,

Srinivas

et al. 2023

Indian J Med Paediatr Oncol

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“…Напротив, ПЭТ обладает большей чувствительно стью в отношении литических поражений, это обу словлено низким уровнем захвата ФДГ в участках костных уплотнений [48][49][50]. Следовательно, при менение ПЭТ без ОСГ с целью идентификации вто ричных поражений недопустимо [51][52][53][54]. Главными минусами использования данного метода являются недостаточная чувствительность к патологическим очагам, обладающим низкой гликолитической ак тивностью, а также возможная гиперфиксация ФДГ в области воспаления [54][55][56].…”

Section: позитронно-эмиссионная томографияunclassified

“…Следовательно, при менение ПЭТ без ОСГ с целью идентификации вто ричных поражений недопустимо [51][52][53][54]. Главными минусами использования данного метода являются недостаточная чувствительность к патологическим очагам, обладающим низкой гликолитической ак тивностью, а также возможная гиперфиксация ФДГ в области воспаления [54][55][56]. Своевременное применение инструменталь ных методов обследования не ограничивается лишь обнаружением патологии, но также позволяет определить тактику лечения и объем пред стоящей терапии, а также оценить динамику процесса.…”

Section: позитронно-эмиссионная томографияunclassified

The Relevance of Osteoscintigraphy Technique in Early Detection of Bone Metastatic Lesions: a Systematic Review

Litvinenko,

Burova

2023

Vestn. rentgenol. radiol.

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Background. Due to intensive blood supply to the red bone marrow, as well as high adhesive abilities of tumor cells, bone tissue is a perfect structure for the metastatic process. Timely identification of the pathological process is highly relevant, since data from numerous sources on the use of radiation methods at later stages indicate the development of severe pathological conditions leading to neurological deficiency and significant decrease in a patient’s quality of life. Objective: to summarize data on the diagnostic effectiveness of osteoscintigraphy (OSG), as well as to conduct a comparative analysis of various diagnostic methods in bone metastases detection. Material and methods. The review was performed according to PRISMA standard (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). It included only full-text articles published in the period from 2015 to 2022, as well as particularly important publications from 2005 to 2014. The search for articles was carried out independently using CyberLeninka, eLibrary, Google Scholar, PubMed/MEDLINE databases, by key terms without the use of language restrictions: “osteoscintigraphy”, “radiology’, “tumors”, “bones”, “diagnosis”. Results. The final analysis included 56 scientific articles by a qualitative indicator. The advantages and disadvantages of the methods, as well as indications for the use of various diagnostic techniques in bone metastatic lesions detection were presented. It was shown that OSG will cost 6 times cheaper than positron emission tomography (PET), and 3 times cheaper than magnetic resonance imaging (MRI). The analysis of using radiation methods demonstrated that the specificity of computed tomography and radiography was at a high level, but this techniques had less pronounced sensitivity, and MRI, OSG and PET had greater sensitivity, but insufficient specificity. In the initial stage of the disease, OSG is one of the main methods of metastatic lesions visualization, but not the only way of diagnosis in diversification strategy aspect. Conclusion. OSG is an effective and informative technique for early detection of bone metastases, allowing to assess the functional state of the tumor and its surrounding tissues, even before the appearance of structural disorders visible by other diagnostic methods. To improve the accuracy of the study, it is advisable to use a set of radiation diagnostic techniques. The choice of a particular method is determined by its technical capability and financial availability.

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“…Major imaging findings in BM are summarized in Table 1. When the primary lesion is located in the thyroid, lung, liver, or kidney, osteoclast activation and its interaction with the bone stroma lead to an osteolytic pattern on CT [47][48][49][50] and low SI in T1WI on MRI [51][52][53][54]. 18 F-FDG PET/CT generally depicts high FDG uptake in BM lesions from the lung [45,55,56], whereas those from the liver or kidney show low FDG uptake [57,58], which is related to FDG avidity of the primary lesion to some extent.…”

Section: Multimodal Imaging According To the Primary Tumor Site And Histologic Typementioning

confidence: 99%

Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis

Moon

Yoo

Lee

et al. 2021

Cells

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Bone metastasis (BM) is the most common malignant bone tumor and a significant cause of morbidity and mortality for patients with cancer. Compared to other metastatic organs, bone has unique characteristics in terms of the tumor microenvironment (TME). Precise assessments of the TME in BM could be an important step for developing an optimized management plan for patient care. Imaging approaches for BM have several advantages, such as biopsy not being required, multiple site evaluation, and serial assessment in the same sites. Owing to the developments of new imaging tracers or imaging modalities, bone TME could be visualized using multimodal imaging techniques. In this review, we describe the BM pathophysiology, diagnostic principles of major imaging modalities, and clinically available imaging modalities to visualize the TME in BM. We also discuss how the interactions between various factors affecting the TME could be visualized using multimodal imaging techniques.

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Bone Metastases of Hepatocellular Carcinoma: Appearance on MRI Using a Standard Abdominal Protocol

Cited by 8 publications

References 28 publications

Case Report with a Review of Literature: Pancoast Syndrome—A Rare Presentation of Metastatic Hepatocellular Carcinoma

Case Report with a Review of Literature: Pancoast Syndrome—A Rare Presentation of Metastatic Hepatocellular Carcinoma

The Relevance of Osteoscintigraphy Technique in Early Detection of Bone Metastatic Lesions: a Systematic Review

Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis

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