Bone mineral content and bone mineral density in adolescent girls with anorexia nervosa ‐ a longitudinal study

Jagielska, Gabriela; Wolańczyc, T.; Komender, J; C, Tomaszewicz-Libudzic; Przedlaki, J.; Ostrowski, K.

doi:10.1034/j.1600-0447.2001.00286.x

Cited by 41 publications

(35 citation statements)

References 16 publications

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“…Importantly, smaller bone size is not due to an actual reduction in the size of the bone but rather the result of a failure to complete the normal growth-related increase in bone size. This is consistent with the observed reduced growth and delayed skeletal age, slowing of pubertal maturation, and reduced linear growth in patients with adolescent onset AN 5,11,19,26 .…”

Section: Discussionsupporting

confidence: 91%

Near Normalisation of Lumbar Spine Bone Density in Young Women with Osteopenia Recovered from Adolescent Onset Anorexia Nervosa: A Longitudinal Study

Bass¹,

Saxon²,

Corral³

et al. 2005

Journal of Pediatric Endocrinology and Metabolism

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To investigate the effect of the progression of adolescent onset anorexia nervosa (AN) on bone parameters we followed two cohorts (Disease cohort and recovered cohort) of adolescents for a total of 5.2 years. In the 'Disease' cohort (n = 18), lumbar spine bone density (BMD) was reduced by 0.6 SD after 0.8 years of disease and was reduced a further 1.0 SD after a total 2.5 years of disease (p < 0.001). At the third lumbar vertebra there was bone loss (-3.7%, p < 0.05) resulting in reduced volumetric BMD (-5.1%, p < 0.08). In the 'recovered' cohort, lumbar spine BMD was reduced by 1.9 SD after 1.7 years of disease, and increased by 1.5 SD after 2.7 years of recovery (p < 0.001). At the third lumbar vertebra there was an increase in bone mass (20.5%, p < 0.001) and bone volume (14.1%, p < 0.001), resulting in increased volumetric BMD (6.3%, p < 0.08). Normalisation of lumbar spine BMD may be achieved in patients with adolescent onset AN when the successful recovery of body weight is combined with the return of regular menses.

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Section: Discussionsupporting

confidence: 91%

Near Normalisation of Lumbar Spine Bone Density in Young Women with Osteopenia Recovered from Adolescent Onset Anorexia Nervosa: A Longitudinal Study

Bass¹,

Saxon²,

Corral³

et al. 2005

Journal of Pediatric Endocrinology and Metabolism

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“…It is possible that the increase in bone remodeling that is observed is a mechanism developed in an attempt to restore bone mass (120,121). However, the large deficit of calcium in these patients (the loss of exogenous sources due to the deficit in alimentation produces liberation of bone calcium to maintain the homeostasis of extracellular fluid) and the deficit in amino acids as a result of fasting make it very difficult to restore bone mass (122).…”

Section: Bone Mineral Density and Bone Markersmentioning

confidence: 99%

Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances

Argente

2002

European Journal of Endocrinology

146

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Anorexia nervosa (AN) is a chronic childhood psychiatric illness that involves a reduction in caloric intake, loss of weight and amenorrhea, either primary or secondary. The diagnostic criteria for AN have been established by the American Psychiatric Association. The prevalence of this disease amongst adolescents and young adults is between 0.5 and 1% and the incidence of new cases per year is approximately 5-10/100 000 between 15 and 19 years of age. A number of endocrine and metabolic disturbances have been described in patients with AN including amenorrhea-oligomenorrhea, delayed puberty, hypothyroidism, hypercortisolism, IGF-I deficiency, electrolyte abnormalities, hypoglycemia and hypophosphatemia, among others. In addition to prolonged amenorrhea, osteopenia and osteoporosis are the most frequent complications leading to clinically relevant fractures and increased fracture risk throughout life. Patients exhibit an alteration in the hypothalamic -pituitary -gonadal axis, which is responsible for the menstrual disorders. The increase in gonadotropin secretion that can be observed after ponderal recuperation suggests that malnutrition could be the most important mechanism involved in the decrease in gonadotropin secretion. The loss of fat tissue as a consequence of nutrient restriction has been associated with hypoleptinemia and abnormal secretion of peptides implicated in food control (neuropeptide Y, melanocortins and corticotropin-releasing factor, among others). A review of the endocrine abnormalities, disturbances in neurotransmitters, as well as a detailed analysis of bone markers and bone mineral density in patients with AN is described.

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“…Despite a good chance of recovery in the long term, many patients follow a chronic course (Steinhausen, 2002). The severity of the disorder combined with the risk of chronicity, and the fact that mainly young people are affected (Toro, 2000), has a great impact on physical health (Díaz-Marsa, Carrasco, Hollander, César, & Saiz-Ruiz, 2000;Jagielska et al, 2001), as well as on the mental health and social adjustment of the affected patients (Padierna, Quintana, Aró stegui, González, & Horcajo, 2000).…”

Section: Introductionmentioning

confidence: 99%

Purging behaviors and comorbidity as predictive factors of quality of life in anorexia nervosa

González-Pinto

Failde

Cristina

et al. 2004

Intl J Eating Disorders

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Bone mineral content and bone mineral density in adolescent girls with anorexia nervosa ‐ a longitudinal study

Cited by 41 publications

References 16 publications

Near Normalisation of Lumbar Spine Bone Density in Young Women with Osteopenia Recovered from Adolescent Onset Anorexia Nervosa: A Longitudinal Study

Near Normalisation of Lumbar Spine Bone Density in Young Women with Osteopenia Recovered from Adolescent Onset Anorexia Nervosa: A Longitudinal Study

Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances

Purging behaviors and comorbidity as predictive factors of quality of life in anorexia nervosa

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