Bone mineral content and serum 25-hydroxyvitamin D concentrations in breast-fed infants with and without supplemental vitamin D: One-year follow-up

Greer, Frank R.; Searcy, John E.; Levin, Ronald S.; Steichen, Jean J.; Steichen-Asche, Paule S.; Tsang, Reginald C.

doi:10.1016/s0022-3476(82)80514-3

Cited by 125 publications

(69 citation statements)

References 10 publications

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“…We found that BMC in our study population at 2 y was similar to that of full-term infants who had received a mixed diet (6)(7)(8). BMC in group F at both 6 mo and 1 y was similar to that of full-term infants fed either commercial formula or a mixed diet (6)(7)(8)(9)(10). One study (9) reported no statistically significant differences in bone mineralization between full-term infants fed human milk and those fed formula; there was, however, greater scatter in the data obtained from human milk-fed infants.…”

Section: Discussionsupporting

confidence: 57%

“…BMC in group F at both 6 mo and 1 y was similar to that of full-term infants fed either commercial formula or a mixed diet (6)(7)(8)(9)(10). One study (9) reported no statistically significant differences in bone mineralization between full-term infants fed human milk and those fed formula; there was, however, greater scatter in the data obtained from human milk-fed infants. Other reports, using different measurement sites and instrumentation, also reported no differences between full-term infants fed human milk and those fed formula at I y (14,15).…”

Section: Discussionmentioning

confidence: 78%

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Bone Mineralization Outcomes in Human Milk-Fed Preterm Infants

et al. 1992

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 78%

Bone Mineralization Outcomes in Human Milk-Fed Preterm Infants

et al. 1992

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“…In those studies, however, values for both BMC and TBC were far above the ranges found in infants. In our study, the range of BMC in the piglets at 19 days was equivalent to that reported in the humerus of newborn premature infants of 28-36 wk gestation (19) or the radius of term infants in the 1st year of life (20). The total body calcium of the piglets at 19 days of age (10-20 g) is equivalent to that of the 31-to 35-wk human fetus (21).…”

Section: Discussionsupporting

confidence: 79%

Bone Mineral Content Reflects Total Body Calcium in Neonatal Miniature Piglets

et al. 1988

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ABSTRACT. We measured bone mineral content (BMC) in 18 neonatal miniature piglets by single photon absorptiometry, total body calcium (TBC) by total body neutron activation analysis, growth, and serum indices of mineral status (calcium, phosphorus, alkaline phosphatase activity). Measurements were begun on day 6, when the piglets were weaned, and were continued to day 19. After weaning, the piglets were assigned randomly to receive one of three diets which differed only in their concentrations of calcium and phosphorus: 100% of the recommended level (diet A), 60% (diet B), and 20% (diet C). No differences were observed among groups during the 19-day study, either in weight gain (48 f 2 g/day) or increment in crown-rump length (2.4 f 0.2 cm/wk). BMC correlated significantly ( p < 0.001) with TBC at 6 (r = 0.83), 13 (r = 0.77), and 19 ( r = 0.93) days. BMC correlated significantly ( p < 0.001) with the ash weight (r = 0.87) and calcium content (r = 0.90) of the corresponding tibial bone segment. Anthropometric parameters and serum indices of mineral status did not predict TBC as accurately as did BMC measurements. We observed a range in BMC measurements in this study that was similar to the range reported for infants in the 1st yr of life. The high correlation between BMC and TBC suggested that BMC is useful in the assessment of mineral status in infants. (Pediatr Res 24:693-695, 1988) Abbreviations BMC, bone mineral content TBC, total body calcium Ca, calcium P, phosphorus AP, alkaline phosphatase CR, crown rump VLBW, very low birth weight Because of mineral deficits accumulated during hospitalization, the bones of VLBW infants often fail to mineralize ade-

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“…However, the long-term consequences of vitamin D insufficiency for mother and child remain to be clarified. A sufficient vitamin D status would probably improve skeletal health in the child (Greer et al, 1982) and may even reduce the risk of developing type 1 diabetes later in life (Cantorna, 2000).…”

Section: Discussionmentioning

confidence: 99%

Postpartum vitamin D insufficiency and secondary hyperparathyroidism in healthy Danish women

et al. 2006

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Objective: To examine vitamin D status and parathyroid function in normal Danish women postpartum. Design: Three cross-sectional measures during follow-up of 89 women postpartum. Subjects and intervention:We assessed vitamin D status by measuring plasma 25-hydroxyvitamin D (P-25OHD) and the degree of secondary hyperparathyroidism by measuring plasma parathyroid hormone (P-PTH) in 89 Caucasian women at three consecutive visits: (mean (range)) 23 (10-37) days (spring), 117 (95-140) days (late summer) and 274 (254-323) days (winter) postpartum. Results: P-25OHD showed seasonal variations with higher values in late summer than in the other periods (Po0.001). At the first visit, 65% received vitamin D supplements. At the following visits, almost 50% were supplemented. Vitamin D insufficiency (P-25OHDo50 nmol/l) occurred more often during winter (28%) than in spring (14%) (Fisher's exact test, P ¼ 0.02) or late summer (7%) (P ¼ 0.0001). Irrespective of season, vitamin D insufficiency occurred most frequent in women who did not take vitamin D supplements (Fisher's exact test, Po0.02). Frank vitamin D deficiency (P-25OHDo25 nmol/l) was observed during winter in 6%. At all three periods, P-25OHD correlated inversely with P-PTH indicating secondary hyperparathyroidism at deficient vitamin D status. During spring, late summer and winter three, one and four females, respectively, had elevated plasma PTH. Conclusion: Vitamin D insufficiency with secondary hyperparathyroidism is a frequent finding in healthy Danish women postpartum and especially during winter. Vitamin D supplements reduced the risk of vitamin D insufficiency, especially during winter. Our results support the importance of increased alertness regarding information of pregnant and lactating women about vitamin D supplements. Furthermore, it has to be studied whether the present recommendations of an intake of 5-10 mg vitamin D/day are sufficient, especially during winter months.

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Bone mineral content and serum 25-hydroxyvitamin D concentrations in breast-fed infants with and without supplemental vitamin D: One-year follow-up

Cited by 125 publications

References 10 publications

Bone Mineralization Outcomes in Human Milk-Fed Preterm Infants

Bone Mineralization Outcomes in Human Milk-Fed Preterm Infants

Bone Mineral Content Reflects Total Body Calcium in Neonatal Miniature Piglets

Postpartum vitamin D insufficiency and secondary hyperparathyroidism in healthy Danish women

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