Bone Mineral Density and Alterations of Bone Metabolism in Children and Adolescents with Type 1 Diabetes Mellitus

Karagüzel, Gülay; Akçurin, Sema; Özdem, Sebahat; Boz, Adil; Bircan, İffet

doi:10.1515/jpem.2006.19.6.805

Cited by 45 publications

(48 citation statements)

References 33 publications

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“…Also, our results are in agreement with Bonfanti et al (39) who found that serum CTX in prepubertal children was within normal range at onset of T1DM and decreased during the follow-up to reach a significant difference compared to controls after months of insulin treatment. Confirming results were also found in previous studies (40) but our results came in contrast with Abd El Dayem et al (41) who reported that T1DM diabetics had low BMD after adjustment (Z score), low bone formation and high bone resorption markers. Pubertal subjects (diabetics and controls) have higher BMD and BMC than the prepubertal.…”

Section: Discussionsupporting

confidence: 89%

CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

Hashim

Ali

Emara³

et al. 2016

Journal of Medical Biochemistry

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SummaryBackgroundIn this study, we investigated the relationship of adiponectin with bone marker changes in Egyptian children and adolescents with T1DM and the effect of disease duration on these markers, as well as the possible correlations between adiponectin and bone markers in these patients.MethodsSixty Egyptian children and adolescent patients with T1DM were studied. Serum adiponectin and collagen breakdown products (cross-linked C-terminal telopeptide of collagen type l »CTX«) were measured and compared to the results of 20 age-matched healthy controls.ResultsAfter adjustment for age, BMI, Tanner stage and gender; (total) adiponectin was significantly higher in all T1DM patients. Serum level of CTX and 25(OH)D showed a marked decrease in diabetics with disease duration > 5 years. Serum level of (total) calcium and inorganic phosphorus (Pi) did not show significant difference from control. CTX was inversely correlated to FBG and T1DM duration. Pi was inversely, while 25(OH)D was directly correlated to FBG. Total calcium showed an inverse correlation with HbA1c. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM.ConclusionsAdiponectin showed no correlation with either CTX or bone homeostatic indices. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM. We recommend further investigation of adiponectin isoforms in a population-based study, to establish a good age- and sex-related reference.

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Section: Discussionsupporting

confidence: 89%

CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

Hashim

Ali

Emara³

et al. 2016

Journal of Medical Biochemistry

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“…However, certain of them indicate the presence of discrete bone mineralisation disorders, such as a decrease of bone formation markers and increase of bone resorption markers [28] or lower bone mineral acquisition [5,26].…”

Section: Discussionmentioning

confidence: 99%

Bone status in adolescents with type 1 diabetes

Chobot¹,

Haffke

Polańska

et al. 2010

Diabetologia

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Aims The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other diseaserelated and growth variables was analysed. Methods Group I consisted of 99 pubertal (Tanner ≥2) adolescents (49 female No correlation between Ad-SoS SDS and sex, DIR or diabetes duration was observed. The lower Ad-SoS SDS reflects reduced bone status, and the reduction was significantly more marked in those patients whose HbA 1c T was higher than 7.0% when compared with those whose HbA 1c T was lower. Conclusions Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent on long-term metabolic control.

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“…Thus, free radicals may increase bone resorption through activation of NF-kB. Several risk factors for osteoporosis, such as smoking [60], hypertension [61] and diabetes mellitus [62,63] are associated with increased oxidative stress. Smoking increases the concentrations of free radicals, which have been suggested to be involved in bone resorption [64].…”

Section: Reactive Oxygen Species and Bone Integ-ritymentioning

confidence: 99%

Calcium Metabolism and Oxidative Stress in Bone Fractures: Role of Antioxidants

Sheweita

Khoshhal²

2007

CDM

198

152

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Calcium ion is an essential structural component of the skeleton. There is growing evidence for the importance of nutrition in the maintenance of bones and joints health. Nutritional imbalance combined with endocrine abnormalities may be involved in osteoporosis. For example, essential fatty acids and their metabolites were reported to have beneficial action in osteoporosis. The mechanism by which fatty acids prevent osteoporosis may involve inhibition of pro-inflammatory cytokines, which are known to have a major role in osteoporosis through induction of oxidative stress which had adverse effects on the skeleton. Other risk factors for osteoporosis, such as smoking, hypertension and diabetes mellitus are also associated with increased oxidative stress and free radicals levels. When bone fracture occurs, a remarkable yield of free radicals is generated by the damaged tissues. However, controlled production of free radicals by normally functioning osteoclasts could accelerate destruction of calcified tissues and assist bone remodeling. Enhanced osteoclastic activity observed in bone disorders may have been responsible for increased production of reactive oxygen species [ROS] in the form of superoxide, which is evident by increased levels of serum malondialdehyde [MDA] levels. One of the most damaging effects of ROS is lipid peroxidation, the end product of which is MDA which also served as a measure of osteoclastic activity. Inhibition of the antioxidant enzymes activities, such as superoxide dismutase and glutathione peroxidase, was found to increase superoxide production by the osteoclasts which represented by increased levels of MDA. Therefore, oxidative stress is an important mediator of bone loss since deficiency of antioxidant vitamins has been found to be more common in the elderly osteoporotic patients. It is concluded from this review that increased free radical production overwhelms the natural antioxidants defense mechanisms, subjecting individuals to hyperoxidant stress and thus leading to osteoporosis. In addition, administration of antioxidants might protect bones from osteoporosis and also might help in the acceleration of healing of fractured bones.

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Bone Mineral Density and Alterations of Bone Metabolism in Children and Adolescents with Type 1 Diabetes Mellitus

Cited by 45 publications

References 33 publications

CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

Bone status in adolescents with type 1 diabetes

Calcium Metabolism and Oxidative Stress in Bone Fractures: Role of Antioxidants

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